NOS1 mutations cause hypogonadotropic hypogonadism with sensory and cognitive deficits that can be reversed in infantile mice

Autor: Konstantina Chachlaki, Andrea Messina, Virginia Delli, Valerie Leysen, Csilla Maurnyi, Chieko Huber, Gaëtan Ternier, Katalin Skrapits, Georgios Papadakis, Sonal Shruti, Maria Kapanidou, Xu Cheng, James Acierno, Jesse Rademaker, Sowmyalakshmi Rasika, Richard Quinton, Marek Niedziela, Dagmar L’Allemand, Duarte Pignatelli, Mirjam Dirlewander, Mariarosaria Lang-Muritano, Patrick Kempf, Sophie Catteau-Jonard, Nicolas J. Niederländer, Philippe Ciofi, Manuel Tena-Sempere, John Garthwaite, Laurent Storme, Paul Avan, Erik Hrabovszky, Alan Carleton, Federico Santoni, Paolo Giacobini, Nelly Pitteloud, Vincent Prevot

Publikováno v: Science Translational Medicine
Science Translational Medicine, 2022, 14 (665), pp.eabh2369. ⟨10.1126/scitranslmed.abh2369⟩
Science translational medicine, vol. 14, no. 665, pp. eabh2369

The nitric oxide (NO) signaling pathway in hypothalamic neurons plays a key role in the regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for reproduction. We hypothesized that a disruption of neuronal NO synthase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b9ba2a2f53ed6983bfc3208da7475d
https://www.hal.inserm.fr/inserm-03841246

NOS1 mutations in humans cause hypogonadotropic hypogonadism with sensory and intellectual comorbidities, reversible experimentally by NO treatment at minipuberty

Autor: Konstantina Chachlaki, Andrea Messina Virginia Delli Valerie Leysen Csilla Maurnyi Chieko Huber Gaëtan Ternier Katalin Skrapits Georgios Papadakis Sonal Shruti Maria Kapanidou Xu Cheng James Acierno Jesse Rademaker Sowmyalakshmi Rasika Richard Quinton Marek Niedziela Dagmar L’allemand Duarte Pignatelli Mirjam Dirlewander Mariarosaria Lang-Muritano Patrick Kempf Sophie Catteau

Publikováno v: Science Translational Medicine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::c4b9ba2a2f53ed6983bfc3208da7475d

Image-guided phenotyping of ovariectomized mice: altered functional connectivity, cognition, myelination, and dopaminergic functionality

Autor: Jaana van Gastel, Rukun Hinz, Abdelkrim Azmi, Stuart Maudsley, Annemie Van der Linden, Charlotte Laloux, A. Langbeen, Peter E.J. Bols, Cynthia Anckaerts, Firat Kara, Valerie Leysen, Disha Shah, Pascal Simoens, Vincent Prevot, Marleen Verhoye

Publikováno v: Neurobiology of aging

A large proportion of the population suffers from endocrine disruption, e.g., menopausal women, which might result in accelerated aging and a higher risk for developing cognitive disorders. Therefore, it is crucial to fully understand the impact of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ae2f0ba17807b1315ad8151ac39188
https://doi.org/10.1016/j.neurobiolaging.2018.10.012

Long-term ovarian hormone deprivation alters functional connectivity, brain neurochemical profile and white matter integrity in the Tg2576 amyloid mouse model of Alzheimer's disease

Autor: Disha Shah, Jasmijn Daans, Yadav Garima, Annemie Van der Linden, Marleen Verhoye, Valerie Leysen, Firat Kara, Jules Jacobs, Julie Hamaide, Rick Voncken, Peter Ponsaerts, Cynthia Anckaerts, Peter E.J. Bols, Vincent Prevot, Zahra Sarwari, Steffen Roßner, Kejal Kantarci, Caroline Guglielmetti, A. Langbeen, Michael E. Belloy, Johan Van Audekerke

Publikováno v: Neurobiology of Aging, 102, pp. 139-150
Neurobiology of Aging, 102, 139-150
Neurobiol Aging
Neurobiology of aging

Premenopausal bilateral ovariectomy is considered to be one of the risk factors of Alzheimer's disease (AD). However, the underlying mechanisms remain unclear. Here, we aimed to investigate long-term neurological consequences of ovariectomy in a rode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f900be8497a5fcdb24545da5b12a31
https://repository.ubn.ru.nl/handle/2066/242956

Reproductive Function During Chronodisruption: Model of Shiftwork in Rodents

Autor: Vincent Prevot, Valerie Leysen

Publikováno v: Endocrinology
Endocrinology, 2020, 161 (12), ⟨10.1210/endocr/bqaa151⟩
Endocrinology, Endocrine Society, 2020, 161 (12), ⟨10.1210/endocr/bqaa151⟩

In female mammals, cycles in reproductive function depend both on the biological clock synchronized to the light/dark cycle and on a balance between the negative and positive feedbacks of estradiol, whose concentration varies during oocyte maturation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104372c2ed4d59be73ece1eb02c5e4bf
https://doi.org/10.1210/endocr/bqaa151