Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Valerie Kouskoff"'
Autor:
Mathew Sheridan, Muhammad Ahmad Maqbool, Anne Largeot, Liam Clayfield, Jingru Xu, Natalia Moncaut, Robert Sellers, Jessica Whittle, Jerome Paggetti, Mudassar Iqbal, Romain Aucagne, Laurent Delva, Syed Murtuza Baker, Michael Lie-a-Ling, Valerie Kouskoff, Georges Lacaud
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-18 (2024)
Abstract Background The epigenetic factors KAT6A (MOZ/MYST3) and KMT2A (MLL/MLL1) interact in normal hematopoiesis to regulate progenitors’ self-renewal. Both proteins are recurrently translocated in AML, leading to impairment of critical different
Externí odkaz:
https://doaj.org/article/9e06903917c740ddb71ed8f77ed9c4dd
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract TAZ::CAMTA1 is a fusion protein found in over 90% of Epithelioid Hemangioendothelioma (EHE), a rare vascular sarcoma with an unpredictable disease course. To date, how TAZ::CAMTA1 initiates tumour formation remains unexplained. To study the
Externí odkaz:
https://doaj.org/article/f8f5c01d0099483396ec497c3588065b
Autor:
Sara Menegatti, Bethany Potts, Roberto Paredes, Eva Garcia-Alegria, Syed Murtuza Baker, Valerie Kouskoff
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107583- (2023)
Summary: During embryonic development, all blood progenitors are initially generated from endothelial cells that acquire a hemogenic potential. Blood progenitors emerge through an endothelial-to-hematopoietic transition regulated by the transcription
Externí odkaz:
https://doaj.org/article/6bb48522d23c4237a23329e5cbe76b45
Autor:
Valerie Kouskoff, Atsushi Asakura
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/5c1513160f9c4a8dabe9b82783e0acef
Autor:
Sara Menegatti, Bethany Potts, Eva Garcia-Alegria, Roberto Paredes, Michael Lie-A-Ling, Georges Lacaud, Valerie Kouskoff
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The transcription factor RUNX1 is a master regulator of blood cell specification. During embryogenesis, hematopoietic progenitors are initially generated from hemogenic endothelium through an endothelium-to-hematopoietic transition controlled by RUNX
Externí odkaz:
https://doaj.org/article/a6f8d5f00ead4d83b87a2eb947b00fef
Autor:
Thierry Jaffredo, Alessandra Balduini, Anna Bigas, Rosa Bernardi, Dominique Bonnet, Bruno Canque, Pierre Charbord, Anna Cumano, Ruud Delwel, Charles Durand, Willem Fibbe, Lesley Forrester, Lucia de Franceschi, Cedric Ghevaert, Bjørn Gjertsen, Berthold Gottgens, Thomas Graf, Olaf Heidenreich, Olivier Hermine, Douglas Higgs, Marina Kleanthous, Hannes Klump, Valerie Kouskoff, Daniela Krause, George Lacaud, Cristina Lo Celso, Joost H.A. Martens, Simón Méndez-Ferrer, Pablo Menendez, Robert Oostendorp, Sjaak Philipsen, Bo Porse, Marc Raaijmakers, Catherine Robin, Henk Stunnenberg, Kim Theilgaard-Mönch, Ivo Touw, William Vainchenker, Joan-Lluis Vives Corrons, Laurent Yvernogeau, Jan Jacob Schuringa
Publikováno v:
HemaSphere, Vol 5, Iss 12, p e669 (2021)
Externí odkaz:
https://doaj.org/article/b92def9715344d93ad65db2c745664f9
Autor:
Eva Garcia-Alegria, Sara Menegatti, Muhammad Z.H. Fadlullah, Pablo Menendez, Georges Lacaud, Valerie Kouskoff
Publikováno v:
Stem Cell Reports, Vol 11, Iss 5, Pp 1061-1074 (2018)
Summary: The differentiation of human embryonic stem cells (hESCs) to hematopoietic lineages initiates with the specification of hemogenic endothelium, a transient specialized endothelial precursor of all blood cells. This in vitro system provides an
Externí odkaz:
https://doaj.org/article/658049c806db483e90829eaad7af45d3
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100367- (2021)
Summary: Little is known about the emergence of blood progenitors during human embryogenesis due to ethical reasons and restricted embryo access. The use of human embryonic stem cells (hESCs) as a model system offers unique opportunities to dissect h
Externí odkaz:
https://doaj.org/article/e3c92cc63ea845ef995745c4ff32fbdb
Autor:
M S Vijayabaskar, Debbie K Goode, Nadine Obier, Monika Lichtinger, Amber M L Emmett, Fatin N Zainul Abidin, Nisar Shar, Rebecca Hannah, Salam A Assi, Michael Lie-A-Ling, Berthold Gottgens, Georges Lacaud, Valerie Kouskoff, Constanze Bonifer, David R Westhead
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 11, p e1007337 (2019)
Gene expression governs cell fate, and is regulated via a complex interplay of transcription factors and molecules that change chromatin structure. Advances in sequencing-based assays have enabled investigation of these processes genome-wide, leading
Externí odkaz:
https://doaj.org/article/ce48b7160bf8439990c2092f2e79e3da
Autor:
Roshana Thambyrajah, Muhammad Z.H. Fadlullah, Martin Proffitt, Rahima Patel, Shaun M. Cowley, Valerie Kouskoff, Georges Lacaud
Publikováno v:
Stem Cell Reports, Vol 10, Iss 4, Pp 1369-1383 (2018)
Summary: The first hematopoietic stem and progenitor cells are generated during development from hemogenic endothelium (HE) through trans-differentiation. The molecular mechanisms underlying this endothelial-to-hematopoietic transition (EHT) remain p
Externí odkaz:
https://doaj.org/article/311a8abdf61b40cbab6730211f9ba1a9