Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Valerie Goss"'
Autor:
Sujit Bidhar, Valerie Goss, Wei-Ying Chen, Andrei Stanishevsky, Meimei Li, Slava Kuksenko, Marco Calviani, Robert Zwaska
Publikováno v:
Physical Review Accelerators and Beams, Vol 24, Iss 12, p 123001 (2021)
In an effort to develop and design next generation high power target materials for particle physics research, the possibility of fabricating nonwoven metallic or ceramic nanofibers by electrospinning process is explored. A low-cost electrospinning un
Externí odkaz:
https://doaj.org/article/1cbf48085d2e4a2a83fe837f91424b49
Autor:
Hélène Poirel, Judith Staerk, Stefan N. Constantinescu, Roberto D. Polakiewicz, John Rush, Christian Pecquet, Ronan Chaligne, Stéphane Giraudier, Kimberley A. Lee, Joanne Van Hees, Xiaowu Zhang, William Vainchenker, Jean-Marie Scheiff, Valerie Goss
Publikováno v:
Blood. 115:1037-1048
Constitutively active JAK2V617F and thrombopoietin receptor (TpoR) W515L/K mutants are major determinants of human myeloproliferative neoplasms (MPNs). We show that a TpoRW515 mutation (W515A), which we detected in 2 myelofibrosis patients, and the
Autor:
Ludovica Riera, Michael J. Comb, Claudia Voena, Giorgio Inghirami, Francesco Boccalatte, Amalia Bosia, Ole N. Jensen, Roberto D. Polakiewicz, John Rush, Julie Nardone, Valerie Goss, Bruce Ruggeri, Mangeng Cheng, Kimberly Lee, Roberto Chiarle, Chiara Riganti, Lucia D'Amico
Publikováno v:
Boccalatte, F E, Voena, C, Riganti, C, Bosia, A, D'Amico, L, Riera, L, Cheng, M, Ruggeri, B, Jensen, O N, Goss, V L, Lee, K, Nardone, J, Rush, J, Polakiewicz, R D, Comb, M J, Chiarle, R & Inghirami, G 2009, ' The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) is enhanced by NPM-ALK : new insights in ALK-mediated pathogenesis and the treatment of ALCL ', Blood, vol. 8, no. 3, pp. 2776-2790 . https://doi.org/10.1182/blood-2008-06-161018
Anaplastic large cell lymphoma represents a subset of neoplasms caused by translocations that juxtapose the anaplastic lymphoma kinase (ALK) to dimerization partners. The constitutive activation of ALK fusion proteins leads to cellular transformation
Autor:
D. Gary Gilliland, Valerie Goss, Ting-Lei Gu, Roberto D. Polakiewicz, Lana Popova, Melanie G. Cornejo, Michael Heinrich, Brian J. Druker, Cynthia Reeves, Kimberly Lee, Jeffrey W. Tyner, Isao Miyoshi, Masanori Daibata, Denise K. Walters, Thomas Mercher, John Rush
Publikováno v:
Blood. 110:323-333
Activated tyrosine kinases have been frequently implicated in the pathogenesis of cancer, including acute myeloid leukemia (AML), and are validated targets for therapeutic intervention with small-molecule kinase inhibitors. To identify novel activate
Autor:
Adam Farchone, Marya Lieberman, Rose Doerfler, Rebecca L. Shute, Keenan P. Linder, Valerie Goss, Corey Gavin, Michelle A. Pillers
Publikováno v:
Journal of Visualized Experiments.
The designed nature and controlled, one-pot synthesis of DNA origami provides exciting opportunities in many fields, particularly nanoelectronics. Many of these applications require interaction with and adhesion of DNA nanostructures to a substrate.
Autor:
Roberto D. Polakiewicz, Thomas Bumm, Amie S. Corbin, Lisa Wood, Michael W. Deininger, Ian J. Griswold, Kara Johnson, Caitlyn Smith, Eric P. Stoffregen, Erika M. Moseson, Brian J. Druker, Kimberly Lee, Mary MacPartlin, Valerie Goss, Thomas O'Hare
Publikováno v:
Molecular and Cellular Biology. 26:6082-6093
Kinase domain (KD) mutations of Bcr-Abl interfering with imatinib binding are the major mechanism of acquired imatinib resistance in patients with Philadelphia chromosome-positive leukemia. Mutations of the ATP binding loop (p-loop) have been associa
Autor:
Roberto D. Polakiewicz, Joan MacNeill, Kimberly Lee, Erik Spek, John Rush, Albrecht Moritz, Julie Nardone, Michael J. Comb, Valerie Goss
Publikováno v:
Blood. 107:4888-4897
The Bcr-Abl fusion kinase drives oncogenesis in chronic myeloid leukemia (CML). CML patients are currently treated with the Abl tyrosine kinase inhibitor imatinib, which is effective in early stages of the disease. However, resistance to imatinib ari
Publikováno v:
Journal of Immunological Methods. 305:59-66
Our understanding of the mechanisms by which BCR-ABL drives CML is based, in part, on the use of model cell lines such as the K562 cell line. However, the BCR-ABL translocation may occur via a number of different junction points. In addition, CML is
Publikováno v:
Journal of Chemical Education. 90:358-360
In this hands-on activity, students map the topography of a hidden surface using an analog atomic force microscope (A-AFM) made from a cardboard box and mailing tubes. Varying numbers of ping pong balls inside the tubes mimic atoms on a surface. Stud
Autor:
Matthias Mueller, George Thomas, Virginie Mieulet, Sara C. Kozma, Jürgen Mestan, Melanie Sticker, Stefano Fumagalli, Sung Hee Um, Valerie Goss, Mario Pende
Publikováno v:
Molecular and Cellular Biology. 24:3112-3124
Recent studies showed that the 40S ribosomal protein S6 kinase (S6K) p70S6K/p85S6K, termed S6K1 (51), is a major effector of cell growth. This conclusion stems from gene deletion studies with Drosophila (39) and with mice (51) as well as recent studi