Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Valerie G Brunton"'
Autor:
Emily R Webb, Georgia L Dodd, Michaela Noskova, Esme Bullock, Morwenna Muir, Margaret C Frame, Alan Serrels, Valerie G Brunton
Publikováno v:
eLife, Vol 12 (2023)
The adhesion protein Kindlin-1 is over-expressed in breast cancer where it is associated with metastasis-free survival; however, the mechanisms involved are poorly understood. Here, we report that Kindlin-1 promotes anti-tumor immune evasion in mouse
Externí odkaz:
https://doaj.org/article/c3ca53b8a4394469ab79acf4dee4d370
Autor:
Callam T Davidson, Eileen Miller, Morwenna Muir, John C Dawson, Martin Lee, Stuart Aitken, Alan Serrels, Scott P Webster, Natalie Z M Homer, Ruth Andrew, Valerie G Brunton, Patrick W F Hadoke, Brian R Walker
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0255709 (2023)
Glucocorticoids inhibit angiogenesis by activating the glucocorticoid receptor. Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) reduces tissue-specific glucocorticoid action and promotes angioge
Externí odkaz:
https://doaj.org/article/b697e841a2b4458d8756871fed0def5e
Autor:
Giovana Carrasco, Ifigeneia Stavrou, Mairi Treanor-Taylor, Henry Beetham, Martin Lee, Roza Masalmeh, Artur Carreras-Soldevila, David Hardman, Miguel O. Bernabeu, Alex von Kriegsheim, Gareth J. Inman, Adam Byron, Valerie G. Brunton
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-12 (2024)
Abstract Kindler syndrome (KS) is a rare genodermatosis resulting from loss-of-function mutations in FERMT1, the gene that encodes Kindlin-1. KS patients have a high propensity to develop aggressive and metastatic cutaneous squamous cell carcinoma (c
Externí odkaz:
https://doaj.org/article/8cc9d5b92cf442b7a04bdf1f0c5b321a
Autor:
Neil O Carragher, Valerie G Brunton, Alan Serrels, Kurt I Anderson, Marta Canel, Paul Timpson, Ewan J McGhee, Beverley Isherwood
Publikováno v:
Pharmaceutics, Vol 3, Iss 2, Pp 141-170 (2011)
Dynamic regulation of specific molecular processes and cellular phenotypes in live cell systems reveal unique insights into cell fate and drug pharmacology that are not gained from traditional fixed endpoint assays. Recent advances in microscopic ima
Externí odkaz:
https://doaj.org/article/7c3efcd6110642da93527a09028de219
Autor:
Jason T Weiss, Craig eFraser, Belén eRubio-Ruiz, Samuel eMyers, Richard eCrispin, John C Dawson, Valerie G Brunton, E Elizabeth Patton, Neil O Carragher, Asier eUnciti-Broceta
Publikováno v:
Frontiers in Chemistry, Vol 2 (2014)
Palladium-activated prodrug therapy is an experimental therapeutic approach that relies on the unique chemical properties and biocompatibility of heterogeneous palladium catalysis to enable the spatially-controlled in vivo conversion of a biochemical
Externí odkaz:
https://doaj.org/article/25f803213dfa41258b2fc34af2dabfff
Autor:
Arkadiusz Welman, Duncan Sproul, Peter Mullen, Morwenna Muir, Andrew R Kinnaird, David J Harrison, Dana Faratian, Valerie G Brunton, Margaret C Frame
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34182 (2012)
Overexpression of matriptase has been reported in a variety of human cancers and is sufficient to trigger tumor formation in mice, but the importance of matriptase in breast cancer remains unclear. We analysed matriptase expression in 16 human breast
Externí odkaz:
https://doaj.org/article/f68ec75a6d1b45c7a524d4794a4d5dae
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e27806 (2011)
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that is elevated in a variety of human cancers. While FAK is implicated in many cellular processes that are perturbed in cancer, including proliferation, actin and adhesion dynamics, polari
Externí odkaz:
https://doaj.org/article/48dd49013c8b4540a152d7bd3a33a798
Autor:
Valerie G. Brunton, Adam Byron, Andrew H. Sims, Donald M. Salter, Jayne Culley, Martin Lee, John C. Dawson, Jocelyn Ward, Morwenna Muir, Helen Creedon, Georgia L. Dodd, Jun Li, Hitesh Patel, Sana Sarvi
Figure S3 shows generation of Kindlin-1 deficient Met-1 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7c800512ee2ce22305e7d69174dcc5
https://doi.org/10.1158/0008-5472.22417580.v1
https://doi.org/10.1158/0008-5472.22417580.v1
Autor:
Valerie G. Brunton, Adam Byron, Andrew H. Sims, Donald M. Salter, Jayne Culley, Martin Lee, John C. Dawson, Jocelyn Ward, Morwenna Muir, Helen Creedon, Georgia L. Dodd, Jun Li, Hitesh Patel, Sana Sarvi
In breast cancer, increased expression of the cytoskeletal adaptor protein Kindlin-1 has been linked to increased risks of lung metastasis, but the functional basis is unknown. Here, we show that in a mouse model of polyomavirus middle T antigen–in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113c507323ff7a9adeaa4e555a5bc4f9
https://doi.org/10.1158/0008-5472.c.6509879.v1
https://doi.org/10.1158/0008-5472.c.6509879.v1
Autor:
Valerie G. Brunton, Adam Byron, Andrew H. Sims, Asier Unciti-Broceta, Morwenna Muir, Jayne Culley, Carolin Temps, David A. Parry, Alexander E.P. Loftus, Olga Murina, Billie G.C. Griffith, Henry Beetham
Supplementary Data from Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae7a4ca1ea41e4bb2ff29dd30e2669e
https://doi.org/10.1158/0008-5472.22430050.v1
https://doi.org/10.1158/0008-5472.22430050.v1