Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Valerie Eligert"'
Autor:
Cassia Overk, Emma Fiorini, Chiara Babolin, Marija Vukicevic, Catherine Morici, Rime Madani, Valerie Eligert, Marie Kosco-Vilbois, Amanda Roberts, Ann Becker, Andrea Pfeifer, William C. Mobley
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionPeople with DS are highly predisposed to Alzheimer’s disease (AD) and demonstrate very similar clinical and pathological features. Ts65Dn mice are widely used and serve as the best-characterized animal model of DS.MethodsWe undertook st
Externí odkaz:
https://doaj.org/article/7e7e2a8942f745cbb81e9ba1997aa1c8
Autor:
Tariq Afroz, Elodie Chevalier, Mickael Audrain, Christopher Dumayne, Tamar Ziehm, Roger Moser, Anne-Laure Egesipe, Lorène Mottier, Monisha Ratnam, Manuela Neumann, Daniel Havas, Romain Ollier, Kasia Piorkowska, Mayank Chauhan, Alberto B. Silva, Samjhana Thapa, Jan Stöhr, Andrej Bavdek, Valerie Eligert, Oskar Adolfsson, Peter T. Nelson, Sílvia Porta, Virginia M.-Y. Lee, Andrea Pfeifer, Marie Kosco-Vilbois, Tamara Seredenina
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106050- (2023)
Effective therapies are urgently needed to safely target TDP-43 pathology as it is closely associated with the onset and development of devastating diseases such as frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) and amyotrophic la
Externí odkaz:
https://doaj.org/article/0ae8a176004d45538a54e3b880d79375
Autor:
Sébastien Berger, Julien Fabrègue, Frédéric Borlat, Patrick C. Fraering, Solenne Ousson, Laurence Anderes, Dirk Beher, Jean-René Alattia, Valerie Eligert, Ishrut Hussain, Mitko Dimitrov
Publikováno v:
The Journal of biological chemistry
gamma-Secretase is a large enzyme complex comprising presenilin, nicastrin, presenilin enhancer 2, and anterior pharynx-defective 1 that mediates the intramembrane proteolysis of a large number of proteins including amyloid precursor protein and Notc
Autor:
Anthony Nichols, David Covini, Anna Quattropani, Jean-François Arrighi, Yves Cambet, Maurizio Maio, Thierry Martin, Olivier Schott, Bernard Françon, Laurence Novo-Perez, Don Simpson, Delphine Marin, Delphine Rivron, Cristina Donini, Agnes Bombrun, Pierre-Alain Vitte, Stefano Crosignani, Wolfgang H. B. Sauer, Isabelle Martinou, Dominique Swinnen, Valerie Eligert, Fabienne Burgat-Charvillon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1516-1519
The discovery of a novel series of S1P1 agonists is described. Starting from a micromolar HTS positive, iterative optimization gave rise to several single-digit nanomolar S1P1 agonists. The compounds were able to induce internalization of the S1P1 re
Autor:
Sebastien Nock, Valerie Eligert, Stefano Crosignani, Manfred Schneider, Agnes Bombrun, Adriano Luis Soares de Souza, Anna Quattropani, Delphine Marin, Susanna Carboni, Fanny Beltran, Patrick Gerber, Jerome Gonzalez, Pierre-Alain Vitte, Jerome Dorbais, Ursula Boschert, Katrin Georgi, Laurence Novo-Perez, Anthony Nichols, Mathilde Muzerelle, Wolfgang H. B. Sauer, Jennifer Hantson, Jean-François Arrighi
Publikováno v:
ChemMedChem. 10(4)
Sphingosine-1-phosphate (S1P) receptor agonists have shown promise as therapeutic agents for multiple sclerosis (MS) due to their regulatory roles within the immune, central nervous system, and cardiovascular system. Here, the design and optimization
Autor:
Isruth Hussain, Paul Smith, Laurence Anderes, Laurence Novo-Perez, Bruno Permanne, Valerie Eligert, Dirk Beher, Solenne Ousson, Anna Quattropani
Publikováno v:
Alzheimer's & Dementia. 7