Výsledky vyhledávání - "Valerie Dolle"

Synthesis and Antiviral Activity of 4-Benzyl Pyridinone Derivatives as Potent and Selective Non-Nucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors

Autor: Laura Tarrago-Litvak, Valerie Dolle, A. Kirn, Michel Legraverend, Marie Line Andreola, Chi Hung Nguyen, Michel Ventura, Anne-Marie Aubertin, Emile Bisagni

Publikováno v: Journal of Medicinal Chemistry. 43:3949-3962

Several 4-benzyl analogues of 5-ethyl-6-methyl-4-(phenylthio)pyridin-2(1H)-ones were synthesized and evaluated for their anti-HIV-l activities. Key transformations include metalation at the 4-C-position of 5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eea84205a600df3d9d45bb0c15f2e3d
https://doi.org/10.1021/jm0009437

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Studies towards 4-C-alkylation of pyridin-2(1H)-one derivatives

Autor: Chi Hung Nguyen, Valerie Dolle, Emile Bisagni

Publikováno v: Tetrahedron. 53:12505-12524

In order to obtain 4-C-alkylated pyridin-2(1H)-ones, two strategies were studied: nucleophilic substitution of 4-chloro-3-nitropyridinone derivatives which essentially failed and lithiations of 2-methoxy-3-pivaloylaminopyridines which gave the expect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f62a7647c44e32aa91b8e52a5d0f450
https://doi.org/10.1016/s0040-4020(97)00771-0

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Synthesis of new non-nucleoside inhibitors of HIV-1

Autor: Emile Bisagni, Odile Ludwig, Anne-Marie Aubertin, Valerie Dolle, Michel Legraverend, Chi Hung Nguyen

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:173-178

Some new 4-arylthio-pyridinones which are related to non-nucleoside RT inhibitors of HIV-1 exhibited significant antiviral activities in cell culture. They have been synthesized from different β-keto esters.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57d2a7293a4d1b17abc116ef54e2297c
https://doi.org/10.1016/0960-894x(95)00584-g

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A New Series of Pyridinone Derivatives as Potent Non-Nucleoside Human Immunodeficiency Virus Type 1 Specific Reverse Transcriptase Inhibitors

Autor: Marie Line Andreola, Anne-Marie Aubertin, André Kirn, Gordon Jamieson, Emile Bisagni, E. Fan, Valerie Dolle, Laura Tarrago-Litvak, Chi Hung Nguyen

Publikováno v: Journal of Medicinal Chemistry. 38:4679-4686

4-(Arylthio)-pyridin-2(1H)-ones variously substituted in their 3-, 5-, and 6-positions have been synthesized as a new series of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)-pyridinone hybrid molecules. Biological studies revealed that som

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a345c9de6ff11f5f929ae7d5f0b4195
https://doi.org/10.1021/jm00023a007

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Non-nucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3'-azido-3'-deoxythymidine (AZT)-resistant polymerase to AZT-5'-triphosphate

Autor: Alberto Pérez-Mediavilla, Valerie Dolle, Juan J. Martinez-Irujo, Laura Tarrago-Litvak, Chi Hung Nguyen, Marie-Line Andreola, Carlos Cruchaga, Leticia Odriozola

Publikováno v: The Journal of biological chemistry. 278(43)

Removal of 3'-azido-3'deoxythymidine (AZT) 3'-azido-3'-deoxythymidine 5'-monophosphate (AZTMP) from the terminated primer mediated by the human HIV-1 reverse transcriptase (RT) has been proposed as a relevant mechanism for the resistance of HIV to AZ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f53ffb0c327c6b237112bb590c601ad
https://pubmed.ncbi.nlm.nih.gov/12917424

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ChemInform Abstract: Synthesis and Antiviral Activity of 4-Benzyl Pyridinone Derivatives as Potent and Selective Non-Nucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors

Autor: Marie Line Andreola, Chi Hung Nguyen, Emile Bisagni, Michel Legraverend, Valerie Dolle, Anne-Marie Aubertin, Laura Tarrago-Litvak, Michel Ventura, A. Kirn

Publikováno v: ChemInform. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41ef3c428547e200f1e7edac32451def
https://doi.org/10.1002/chin.200110130

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Effect of nucleoside analogs and non-nucleoside inhibitors of HIV-1 reverse transcriptase on cell-free virions

Autor: H. J. A. Fleury, Laura Tarrago-Litvak, Simon Litvak, Valerie Dolle, Chi Hung Nguyen, Michel Ventura, Michel Legraverend

Publikováno v: Archives of virology. 144(3)

Reverse transcription takes place in the cytoplasm of infected cells, although it has been demonstrated that retroviruses can also initiate reverse transcription prior to infection of target cells. In addition to partial reverse transcripts, full-len

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d857dfe6f50fab9befe1cc761481b6d
https://pubmed.ncbi.nlm.nih.gov/10226617

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