Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Valerie Czepczor"'
Autor:
Tushar Jain, Bianka Prinz, Alexander Marker, Alexander Michel, Katrin Reichel, Valerie Czepczor, Sylvie Klieber, Wei Sun, Sagar Kathuria, Sevim Oezguer Bruederle, Christian Lange, Lena Wahl, Charles Starr, Alessandro Masiero, Lindsay Avery
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
In vitro assessments for the prediction of pharmacokinetic (PK) behavior of biotherapeutics can help identify corresponding liabilities significantly earlier in the discovery timeline. This can minimize the need for extensive early in vivo PK charact
Externí odkaz:
https://doaj.org/article/38817983990a4fd685f565a20d0c4cd1
Autor:
Frederico Nardi, Jean-Paul Nicolas, Laurent Debussche, Loreley Calvet, Irene Kochems, Mark Brönstrup, Stefan Pelzer, Michael Kurz, Tietgen Heiko, Peer Lukat, Rolf Müller, Dietmar Schummer, Jidong Zhang, Agnes Mühlenweg, Holger Hoffmann, Patricia Vrignaud, Valerie Czepczor, Silke C. Wenzel, Sabine Haag-Richter
Publikováno v:
Angewandte Chemie. 127:15781-15785
Bengamide, aus marinen Schwammen stammende und als Inhibitoren der Methionin-Aminopeptidase (MetAP) charakterisierte Naturstoffe, wurden intensiv als Wirkstoffe gegen Krebs erforscht. In einem multidisziplinaren Forschungsprojekt haben wir die Bereit
Autor:
Loreley Calvet, Sabine Haag-Richter, Frederico Nardi, Peer Lukat, Patricia Vrignaud, Jean-Paul Nicolas, Jidong Zhang, Irene Kochems, Silke C. Wenzel, Mark Brönstrup, Tietgen Heiko, Michael Kurz, Laurent Debussche, Dietmar Schummer, Valerie Czepczor, Stefan Pelzer, Rolf Müller, Holger Hoffmann, Agnes Mühlenweg
Publikováno v:
Angewandte Chemie International Edition. 54:15560-15564
The bengamides, sponge-derived natural products that have been characterized as inhibitors of methionine aminopeptidases (MetAPs), have been intensively investigated as anticancer compounds. We embarked on a multidisciplinary project to supply bengam
Autor:
Gary McCort, Rosalia Arrebola, Loreley Calvet, Baptiste Ronan, Fabrice Vergne, Francis Duffieux, Alexey Rak, Isabelle Meaux, David Papin, Florence Fassy, Cecile Delorme, Magali Matthieu, Jean-Paul Nicolas, Christophe Marcireau, Valerie Steier, Pierre-Yves Abecassis, Valerie Czepczor, Heather A. Thomson, Christopher D. Hupp, J.P. Guilinger, Ying Zhang, Anthony D. Keefe, John W. Cuozzo, Julie Liu, Laurent Debussche
Publikováno v:
Cancer Research. 79:3070-3070
From a screening of 27 106 covalent DNA-encoded compound library, a novel KRAS G12C chemical series has been identified. Original hit series compound displayed low µM covalent binding activity to KRAS G12C under GDP form associated with a k(inact)/K