Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Valerie Croons"'
Autor:
Koen M Marien, Valerie Croons, Yannick Waumans, Ellen Sluydts, Stefanie De Schepper, Luc Andries, Wim Waelput, Erik Fransen, Peter B Vermeulen, Mark M Kockx, Guido R Y De Meyer
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161496 (2016)
Despite all efforts made to develop predictive biomarkers for antiangiogenic therapies, no unambiguous markers have been identified so far. This is due to among others the lack of standardized tests. This study presents an improved microvessel densit
Externí odkaz:
https://doaj.org/article/421154d6011b40f5a40660f694122414
Publikováno v:
Current vascular pharmacology
ResearcherID
ResearcherID
Atherosclerotic plaque destabilization is a major cause of unstable angina, myocardial infarction, and sudden cardiac death. Macrophages, which are an essential component of unstable plaques, play a pivotal role in the destabilization process, wherea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc82fb053857dad29a4400f2f961e7e5
https://doi.org/10.2174/157016110791330816
https://doi.org/10.2174/157016110791330816
Publikováno v:
The journal of pharmacology and experimental therapeutics
Because macrophages play a major role in atherosclerotic plaque destabilization, selective removal of macrophages represents a promising approach to stabilize plaques. We showed recently that the protein synthesis inhibitor cycloheximide, in contrast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1e40e8d51d164b18056585ad83169c
https://doi.org/10.1124/jpet.108.149948
https://doi.org/10.1124/jpet.108.149948
Publikováno v:
The journal of pharmacology and experimental therapeutics
Recent evidence indicates that the protein synthesis inhibitor cycloheximide triggers selective macrophage death in rabbit atheroma-like lesions without affecting smooth muscle cells (SMCs) or the endothelium, thereby favoring a stable plaque phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b6e5effa8548dd017493d9da0cb299
https://doi.org/10.1124/jpet.107.132944
https://doi.org/10.1124/jpet.107.132944
Publikováno v:
British Journal of Pharmacology. 152:493-500
Background and purpose: Macrophages in atherosclerotic plaques have a tremendous impact on atherogenesis and plaque destabilization. We previously demonstrated that treatment of plaques in cholesterol-fed rabbits with the nitric oxide (NO) donor mols
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdc3edb56aba1fae1c39453f8636c93c
https://doi.org/10.1038/sj.bjp.0707426
https://doi.org/10.1038/sj.bjp.0707426
Autor:
Inge De Meyer, Sander M. Houten, Guido R.Y. De Meyer, Hidde Bult, Wim Martinet, Arnold G. Herman, Valerie Croons
Publikováno v:
Journal of cardiovascular pharmacology
Journal of cardiovascular pharmacology, 55(3), 269-275. Lippincott Williams and Wilkins
Journal of cardiovascular pharmacology, 55(3), 269-275. Lippincott Williams and Wilkins
Because macrophages play an important role in the destabilization of atherosclerotic plaques, and smooth muscle cells (SMCs) contribute to plaque stability, selective clearance of macrophages in atherosclerotic plaques is a promising strategy for pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57c8ce7ca51149679340f2c66ab07fd
https://hdl.handle.net/10067/810030151162165141
https://hdl.handle.net/10067/810030151162165141
Publikováno v:
Annals of the New York Academy of Sciences
Unstable atherosclerotic plaques are characterized by a thin fibrous cap that contains few smooth muscle cells (SMCs) and numerous foam cells of macrophage origin. Previously we and others demonstrated that macrophages disappear from atherosclerotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10944512f7932e925c27ea370486051b
https://hdl.handle.net/10067/776260151162165141
https://hdl.handle.net/10067/776260151162165141
Publikováno v:
The journal of pharmacology and experimental therapeutics
Macrophages are an essential component of unstable atherosclerotic plaques and play a pivotal role in the destabilization process. We have demonstrated previously that local delivery of the mammalian target of rapamycin (mTOR) inhibitor everolimus se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39080a87c720298505a51843affc86f2
https://hdl.handle.net/10067/616160151162165141
https://hdl.handle.net/10067/616160151162165141