Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Valerie Coppard"'
Autor:
Valerie Coppard, Grisha Szep, Zoya Georgieva, Sarah K. Howlett, Lorna B. Jarvis, Daniel B. Rainbow, Ondrej Suchanek, Edward J. Needham, Hani S. Mousa, David K. Menon, Felix Feyertag, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Joanne L. Jones
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
As the dimensionality, throughput and complexity of cytometry data increases, so does the demand for user-friendly, interactive analysis tools that leverage high-performance machine learning frameworks. Here we introduce FlowAtlas: an interactive web
Externí odkaz:
https://doaj.org/article/38abc65bbc2440418eb7722db7fcaa14
Autor:
Lorna B. Jarvis, Daniel B. Rainbow, Valerie Coppard, Sarah K. Howlett, Zoya Georgieva, Jessica L. Davies, Harpreet Kaur Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James T. Grist, Alasdair J. Coles, Hani S. Mousa, Stefano Pluchino, Krishnaa T. Mahbubani, Julian L. Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda S. Wicker, Joanne L. Jones
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Jarvis et al demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A)-driven acquisition of CD73 expression, which along with CD39, ena
Externí odkaz:
https://doaj.org/article/45140660645e4b33867eb3d5efef93f6
Autor:
Paul K. Grant, Gregory Szep, Om Patange, Jacob Halatek, Valerie Coppard, Attila Csikász-Nagy, Jim Haseloff, James C. W. Locke, Neil Dalchau, Andrew Phillips
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Morphogen gradients can be dynamic and transient yet give rise to stable cellular patterns. Here the authors show that a synthetic morphogen-induced mutual inhibition circuit produces stable boundaries when the spatial average of morphogens falls wit
Externí odkaz:
https://doaj.org/article/16fc968713644a57910ee1bc73fd0b96
Autor:
Valerie Coppard, David K. Menon, Alasdair Coles, Edward Needham, R.J. Digby, Joanne L. Jones, Hani S Mousa
The inflammatory response to acute brain injuries is a key contributor to subsequent outcome. The study of local central nervous system inflammatory responses is hindered by raised intracranial pressure precluding cerebrospinal fluid sampling by lumb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640037683c65d35cdc2363837447cd85
https://www.repository.cam.ac.uk/handle/1810/329120
https://www.repository.cam.ac.uk/handle/1810/329120
Autor:
Lorna Jarvis, Daniel Rainbow, Valerie Coppard, Sarah Howlett, Jessica Davies, Harpreet Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James Grist, Alasdair Coles, Hani Mousa, Stefano Pluchino, Krishnaa Mahbubani, Julian Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda Wicker, Joanne Jones
The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5efe9dd65a5c327360df86e632c678a
https://doi.org/10.21203/rs.3.rs-92789/v1
https://doi.org/10.21203/rs.3.rs-92789/v1
Autor:
Daniel B. Rainbow, Lorna B. Jarvis, Valerie Coppard, Hani S Mousa, Joanne L. Jones, Alasdair Coles, Zoya Georgieva, Fadi Issa, Kourosh Saeb-Parsy, Krishnaa T. Mahbubani, Stefano Pluchino, Tom Ashmore, Sarah Howlett, Julian L. Griffin, Luca Peruzzotti-Jametti, Linda S. Wicker, Aletta Van Den Bosch, Joanna Hester, Harpreet Kaur Mullay, James T. Grist, Jessica L. Davies
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing
Autor:
Valerie Coppard, Gregory Szep, Om Patange, Attila Csikász-Nagy, Jacob Halatek, Neil Dalchau, Paul K. Grant, Jim Haseloff, James C. W. Locke, Andrew Phillips
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
During development, cells gain positional information through the interpretation of dynamic morphogen gradients. A proposed mechanism for interpreting opposing morphogen gradients is mutual inhibition of downstream transcription factors, but isolatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c065b74f350e7a8988a6b6b2a51bc858