Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Valerie Copie"'
Autor:
Rachel A. Rawle, Monika Tokmina-Lukaszewska, Zunji Shi, Yoon-Suk Kang, Brian P. Tripet, Fang Dang, Gejiao Wang, Timothy R. McDermott, Valerie Copie, Brian Bothner
Publikováno v:
Microorganisms, Vol 8, Iss 9, p 1339 (2020)
Arsenite (AsIII) oxidation is a microbially-catalyzed transformation that directly impacts arsenic toxicity, bioaccumulation, and bioavailability in environmental systems. The genes for AsIII oxidation (aio) encode a periplasmic AsIII sensor AioX, tr
Externí odkaz:
https://doaj.org/article/771dea0e4bba461b8ed224c1916bfecb
Autor:
Stephanann M. Costello, Anastasia Schultz, Donald Smith, Danielle Horan, Martha Chaverra, Brian Tripet, Lynn George, Brian Bothner, Frances Lefcort, Valérie Copié
Publikováno v:
Metabolites, Vol 14, Iss 8, p 423 (2024)
Neurodegenerative retinal diseases such as glaucoma, diabetic retinopathy, Leber’s hereditary optic neuropathy (LHON), and dominant optic atrophy (DOA) are marked by progressive death of retinal ganglion cells (RGC). This decline is promoted by str
Externí odkaz:
https://doaj.org/article/700f0a0de6b64b1c8235f042b22b80ef
Autor:
Katherine F. Steward, Mohammed Refai, William E. Dyer, Valérie Copié, Jennifer Lachowiec, Brian Bothner
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Variation in omics data due to intrinsic biological stochasticity is often viewed as a challenging and undesirable feature of complex systems analyses. In fact, numerous statistical methods are utilized to minimize the variation a
Externí odkaz:
https://doaj.org/article/8e83f0cf2c2d488c842c3e0e09c5fc71
Autor:
Alexandra M. Cheney, Stephanann M. Costello, Nicholas V. Pinkham, Annie Waldum, Susan C. Broadaway, Maria Cotrina-Vidal, Marc Mergy, Brian Tripet, Douglas J. Kominsky, Heather M. Grifka-Walk, Horacio Kaufmann, Lucy Norcliffe-Kaufmann, Jesse T. Peach, Brian Bothner, Frances Lefcort, Valérie Copié, Seth T. Walk
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Familial dysautonomia is a rare genetic disease caused in part by neurodegeneration. Here, the authors show that the gut-metabolism axis is altered in both patients and transgenic mice and that disease pathology is ameliorated by controlling microbio
Externí odkaz:
https://doaj.org/article/5e2396870a5d4bfcb87f889c0da6953f
Autor:
Krzysztof Ossoliński, Tomasz Ruman, Valérie Copié, Brian P. Tripet, Leonardo B. Nogueira, Katiane O.P.C. Nogueira, Artur Kołodziej, Aneta Płaza-Altamer, Anna Ossolińska, Tadeusz Ossoliński, Joanna Nizioł
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 12, Iss 6, Pp 889-900 (2022)
Bladder cancer (BC) is one of the most frequently diagnosed types of urinary cancer. Despite advances in treatment methods, no specific biomarkers are currently in use. Targeted and untargeted profiling of metabolites and elements of human blood seru
Externí odkaz:
https://doaj.org/article/62e9b1f352194e8f9d72fda067f25e95
Autor:
Jesse T. Peach, Rebecca C. Mueller, Dana J. Skorupa, Margaux M. Mesle, Sutton Kanta, Eric Boltinghouse, Bailey Sharon, Valerie Copié, Brian Bothner, Brent M. Peyton
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Research focused on microbial populations of thermoalkaline springs has been driven in a large part by the lure of discovering functional enzymes with industrial applications in high-pH and high temperature environments. While several studie
Externí odkaz:
https://doaj.org/article/1124f0deb6ca42b9ba8aa2075be29bcb
Autor:
Lei Yu, Sarim Yousuf, Shahrukh Yousuf, Jeffrey Yeh, Scott W. Biggins, Chihiro Morishima, Irene Shyu, Galen O’Shea-Stone, Brian Eilers, Annie Waldum, Valérie Copié, Jason Burkhead
Publikováno v:
Hepatology Communications, Vol 7, Iss 3, Pp e0076-e0076 (2023)
Background and Aim:. Copper is an essential trace metal serving as a cofactor in innate immunity, metabolism, and iron transport. We hypothesize that copper deficiency may influence survival in patients with cirrhosis through these pathways. Methods:
Externí odkaz:
https://doaj.org/article/12d9bf9df5224c56bb0ae8b746879659
Autor:
Galen O’Shea-Stone, Rachelle Lambert, Brian Tripet, James Berardinelli, Jennifer Thomson, Valerie Copié, Robert Garrott
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Environmental metabolomics has the potential to facilitate the establishment of a new suite of tools for assessing the physiological status of important wildlife species. A first step in developing such tools is to evaluate the impacts of va
Externí odkaz:
https://doaj.org/article/fa3cc74fb7bc4d18b1b0418140ce6284
Autor:
Stephanann M. Costello, Alexandra M. Cheney, Annie Waldum, Brian Tripet, Maria Cotrina-Vidal, Horacio Kaufmann, Lucy Norcliffe-Kaufmann, Frances Lefcort, Valérie Copié
Publikováno v:
Metabolites, Vol 13, Iss 3, p 433 (2023)
Central metabolism has a profound impact on the clinical phenotypes and penetrance of neurological diseases such as Alzheimer’s (AD) and Parkinson’s (PD) diseases, Amyotrophic Lateral Sclerosis (ALS) and Autism Spectrum Disorder (ASD). In contras
Externí odkaz:
https://doaj.org/article/11a137d9ed8447a9b8775f94c1799dc1