Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Valerie Booth"'
Publikováno v:
BBA Advances, Vol 2, Iss , Pp 100057- (2022)
Understanding how non-lipid components of bacteria affect antimicrobial peptide (AMP)-induced membrane disruption is important for a comprehensive understanding of AMP mechanisms and informing AMP-based drug development. This study investigates how l
Externí odkaz:
https://doaj.org/article/5245563207a241ecb241753c48b631d3
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
While peptides can be excellent therapeutics for several conditions, their limited in vivo half-lives have been a major bottleneck in the development of therapeutic peptides. Conjugating the peptide to an inert chemical moiety is a strategy that has
Externí odkaz:
https://doaj.org/article/eb5ea941c5eb493395f97b07688ce0da
Autor:
Sarika Kumari, Valerie Booth
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2740 (2022)
Much of the work probing antimicrobial peptide (AMP) mechanisms has focussed on how these molecules permeabilize lipid bilayers. However, AMPs must also traverse a variety of non-lipid cell envelope components before they reach the lipid bilayer. Add
Externí odkaz:
https://doaj.org/article/66885cf75dc642428ad636728a94aae4
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 16, p 3863 (2019)
Although lung surfactant protein B (SP-B) is an essential protein that plays a crucial role in breathing, the details of its structure and mechanism are not well understood. SP-B forms covalent homodimers, and in this work we use all-atom molecular d
Externí odkaz:
https://doaj.org/article/124c70242ebc4ed288d0ff1f496d0f6e
Publikováno v:
PeerJ, Vol 3, p e1516 (2015)
Differential Scanning Calorimetry (DSC) of intact Escherichia coli (E. coli) was used to identify non-lipidic targets of the antimicrobial peptide (AMP) MSI-78. The DSC thermograms revealed that, in addition to its known lytic properties, MSI-78 also
Externí odkaz:
https://doaj.org/article/402b13d8f3ba405eb3bc2854eb2d7a44
Autor:
Mahzad Sharifahmadian, Muzaddid Sarker, Dharamaraju Palleboina, Alan J Waring, Frans J Walther, Michael R Morrow, Valerie Booth
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72821 (2013)
Breathing is enabled by lung surfactant, a mixture of proteins and lipids that forms a surface-active layer and reduces surface tension at the air-water interface in lungs. Surfactant protein B (SP-B) is an essential component of lung surfactant. In
Externí odkaz:
https://doaj.org/article/3a7047e54ade4c34b1e79abb5bfde68f
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72248 (2013)
The hydrophobic lung surfactant SP-B is essential for respiration. SP-B promotes spreading and adsorption of surfactant at the alveolar air-water interface and may facilitate connections between the surface layer and underlying lamellar reservoirs of
Externí odkaz:
https://doaj.org/article/4945cec648d549489eb4404789d31632
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23052 (2011)
As a major component of the innate immune system, natural killer cells are responsible for activating the cytolytic killing of certain pathogen-infected or tumor cells. The self-recognition of natural killer cells is achieved in part by the killer ce
Externí odkaz:
https://doaj.org/article/6de9924bb082403ba32437804a770eec
Publikováno v:
The journal of physical chemistry. B. 126(29)
Antimicrobial peptides (AMPs) offer advantages over conventional antibiotics; for example, bacteria develop more resistance to small-molecule antibiotics than to AMPs. The interaction of the AMPs with the lipopolysaccharide (LPS) layer of the Gram-ne
Autor:
Anne Griffin, Tammy Benteau, Sumit K. Agrawal, Cindy Penney, Christopher N. Rowley, Courtney MacDonald, Valerie Booth, Lorne S. Parnes, Ahmed A. Mostafa, Susan J Moore, Terry-Lynn Young, Lisbeth Tranebjærg, Tony Batten, Darren D. O’Rielly, Matthew B. Lucas, Curtis R. French, Leichelle A. Little, Nanna Dahl Rendtorff, Jim Houston, Pingzhao Hu, Justin A. Pater, Danielle French, Susan G. Stanton, Dante Galutira, Kathy Hodgkinson, Nelly Abdelfatah, Lance P. Doucette, Jessica E. Besaw
Publikováno v:
Abdelfatah, N, Mostafa, A A, French, C R, Doucette, L P, Penney, C, Lucas, M B, Griffin, A, Booth, V, Rowley, C, Besaw, J E, Tranebjærg, L, Rendtorff, N D, Hodgkinson, K A, Little, L A, Agrawal, S, Parnes, L, Batten, T, Moore, S, Hu, P, Pater, J A, Houston, J, Galutira, D, Benteau, T, MacDonald, C, French, D, O’Rielly, D D, Stanton, S G & Young, T L 2022, ' A pathogenic deletion in Forkhead Box L1 (FOXL1) identifies the first otosclerosis (OTSC) gene ', Human Genetics, vol. 141, pp. 965–979 . https://doi.org/10.1007/s00439-021-02381-1
Otosclerosis is a bone disorder of the otic capsule and common form of late-onset hearing impairment. Considered a complex disease, little is known about its pathogenesis. Over the past 20 years, ten autosomal dominant loci (OTSC1-10) have been mappe