Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Valerie B O'Leary"'
Autor:
Bandita Bagchi, Ahmed Al-Sabi, Seshu Kaza, Dimitri Scholz, Valerie B O'Leary, J Oliver Dolly, Saak V Ovsepian
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87736 (2014)
The molecular determinants of abnormal propagation of action potentials along axons and ectopic conductance in demyelinating diseases of the central nervous system, like multiple sclerosis (MS), are poorly defined. Widespread interruption of myelin o
Externí odkaz:
https://doaj.org/article/b2e9988c15d54a3aac934168086d3463
Publikováno v:
Heliyon, Vol 9, Iss 8, Pp e19050- (2023)
In addition to primary reproductive functions, gonadal hormones play an important role in an array of neural mechanisms across the human lifespan. The ageing-related decline in their activity has been linked to the deterioration of cognitive function
Externí odkaz:
https://doaj.org/article/f648d93932514246a532176c8eeb86bc
Autor:
Saak V, Ovsepian, Valerie B, O'Leary
Publikováno v:
Neuroscience. 504:75-78
Autoantibodies to neuronal antigens are viewed as potential biomarkers for neurodegenerative diseases. Increasing evidence, however, suggests a dissociation of the neurodegenerative process in the central nervous system and dynamics of neuronal prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcac77f935afda9823d70417bde4681a
https://doi.org/10.1016/j.neuroscience.2022.09.019
https://doi.org/10.1016/j.neuroscience.2022.09.019
Publikováno v:
Neurotherapeutics.
In neurodegenerative diseases, changes in neuronal proteins in the cerebrospinal fluid and blood are viewed as potential biomarkers of the primary pathology in the central nervous system (CNS). Recent reports suggest, however, that level of neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03cd71a8658f7ca9f2d6a42e86715e64
https://doi.org/10.1007/s13311-023-01355-7
https://doi.org/10.1007/s13311-023-01355-7
Publikováno v:
The Neuroscientist. 27:222-234
Although neurocognitive deficit is the best-recognized indicator of Alzheimer’s disease (AD), psychotic and other noncognitive symptoms are the prime cause of institutionalization. BACE1 is the rate-limiting enzyme in the production of Aβ of AD, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2957a1754dfe32ce34f1b892180915c
https://doi.org/10.1177/1073858420940943
https://doi.org/10.1177/1073858420940943
Publikováno v:
Drug Discovery Today. 24:1968-1984
The neuromuscular junction (NMJ) is the principal site for the translation of motor neurochemical signals to muscle activity. Therefore, the release and sensing machinery of acetylcholine (ACh) along with muscle contraction are two of the main target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0807e2d8be93ba45471daa024008043b
https://doi.org/10.1016/j.drudis.2019.06.012
https://doi.org/10.1016/j.drudis.2019.06.012
Publikováno v:
Journal of Cellular Physiology. 234:19464-19470
Radiation exposure can evoke cellular stress responses. Emerging recognition that long non-coding RNAs (lncRNAs) act as regulators of gene expression has broadened the spectra of molecules controlling the genomic landscape upon alterations in environ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6cffdfda3f0d42564c7f9ab7fd4820
https://doi.org/10.1002/jcp.28739
https://doi.org/10.1002/jcp.28739
Autor:
Saak V. Ovsepian, Vasilis Ntziachristos, Valerie B. O'Leary, Naira M. Ayvazyan, Ahmed Al-Sabi, James Oliver Dolly
Publikováno v:
Pharmacology & Therapeutics. 193:135-155
Synaptic transmission is a fundamental neurobiological process enabling exchange of signals between neurons as well as neurons and their non-neuronal effectors. The complex molecular machinery of the synaptic vesicle cycle and transmitter release has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbbf4e8f7e64cf3b8ab73b7da9162e5
https://doi.org/10.1016/j.pharmthera.2018.08.016
https://doi.org/10.1016/j.pharmthera.2018.08.016
The reinstatement and revision of abandoned therapeutic ventures of the past has been an integral part of medical research and advancement. In psychiatry, much interest was generated recently by emerging data on the use of faecal supplements for rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f4b78f71d9cf0419d877bdee9eb31f
http://gala.gre.ac.uk/id/eprint/35160/6/35160_OVSEPIAN_Mainstream_psychiatry_reinstates_therapeutic_ventures.pdf
http://gala.gre.ac.uk/id/eprint/35160/6/35160_OVSEPIAN_Mainstream_psychiatry_reinstates_therapeutic_ventures.pdf
Publikováno v:
Neurotherapeutics
Tuberous sclerosis complex (TSC) is a dominant autosomal genetic disorder caused by loss-of-function mutations in TSC1 and TSC2, which lead to constitutive activation of the mammalian target of rapamycin C1 (mTORC1) with its decoupling from regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ee06a5afc8b8fe987b80dc03c68e27
https://pubmed.ncbi.nlm.nih.gov/33398801
https://pubmed.ncbi.nlm.nih.gov/33398801