Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Valerie A.C.M. Koeken"'
Autor:
Chunying Peng, Xun Jiang, Martin Jaeger, Pepijn van Houten, Antonius E. van Herwaarden, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Vera P. Mourits, Heidi Lemmers, Helga Dijkstra, Hans J.P.M. Koenen, Irma Joosten, Bram van Cranenbroek, Yang Li, Leo A.B. Joosten, Mihai G. Netea, Romana T. Netea-Maier, Cheng-Jian Xu
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104935- (2024)
Summary: Background: Endogenous steroid hormones have significant effects on inflammatory and immune processes, but the immunological activities of steroidogenesis precursors remain largely unexplored. Methods: We conducted a systematic approach to e
Externí odkaz:
https://doaj.org/article/c4da9316b306442c8b252dd413d97213
Autor:
Anaísa V. Ferreira, Sarantos Kostidis, Laszlo A. Groh, Valerie A.C.M. Koeken, Mariolina Bruno, Ilayda Baydemir, Gizem Kilic, Özlem Bulut, Theano Andriopoulou, Victoria Spanou, Kalliopi D. Synodinou, Theologia Gkavogianni, Simone J.C.F.M. Moorlag, L. Charlotte de Bree, Vera P. Mourits, Vasiliki Matzaraki, Werner J.H. Koopman, Frank L. van de Veerdonk, Georgios Renieris, Martin Giera, Evangelos J. Giamarellos-Bourboulis, Boris Novakovic, Jorge Domínguez-Andrés
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112658- (2023)
Summary: Itaconate is an immunomodulatory metabolite produced by immune cells under microbial stimulation and certain pro-inflammatory conditions and triggers antioxidant and anti-inflammatory responses. We show that dimethyl itaconate, a derivative
Externí odkaz:
https://doaj.org/article/6e7649ccdf4846afb0796f373689a5d6
Autor:
Wenchao Li, Simone J.C.F.M. Moorlag, Valerie A.C.M. Koeken, Rutger J. Röring, L. Charlotte J. de Bree, Vera P. Mourits, Manoj K. Gupta, Bowen Zhang, Jianbo Fu, Zhenhua Zhang, Inge Grondman, Krista E. van Meijgaarden, Liang Zhou, Ahmed Alaswad, Leo A.B. Joosten, Reinout van Crevel, Cheng-Jian Xu, Mihai G. Netea, Yang Li
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112487- (2023)
Summary: Bacillus Calmette-Guérin (BCG) vaccination is a prototype model for the study of trained immunity (TI) in humans, and results in a more effective response of innate immune cells upon stimulation with heterologous stimuli. Here, we investiga
Externí odkaz:
https://doaj.org/article/eb1c8ea632d74699ab8d95c27ce700ab
Autor:
Bowen Zhang, Zhenhua Zhang, Valerie A.C.M. Koeken, Saumya Kumar, Michelle Aillaud, Hsin-Chieh Tsay, Zhaoli Liu, Anke R.M. Kraft, Chai Fen Soon, Ivan Odak, Berislav Bošnjak, Anna Vlot, Morris A. Swertz, Uwe Ohler, Robert Geffers, Thomas Illig, Jochen Huehn, Antoine-Emmanuel Saliba, Leif Erik Sander, Reinhold Förster, Cheng-Jian Xu, Markus Cornberg, Leon N. Schulte, Yang Li
Publikováno v:
Cell Genomics, Vol 3, Iss 2, Pp 100232- (2023)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe COVID-19 in some patients and mild COVID-19 in others. Dysfunctional innate immune responses have been identified to contribute to COVID-19 severity, but th
Externí odkaz:
https://doaj.org/article/1d8a821dff98448fb35c91743f5b812b
Autor:
Jorge Domínguez-Andrés, Rob J.W. Arts, Siroon Bekkering, Harsh Bahrar, Bastiaan A. Blok, L. Charlotte J. de Bree, Mariolina Bruno, Özlem Bulut, Priya A. Debisarun, Helga Dijkstra, Jéssica Cristina dos Santos, Anaísa V. Ferreira, Daniela Flores-Gomez, Laszlo A. Groh, Inge Grondman, Leonie Helder, Cor Jacobs, Liesbeth Jacobs, Trees Jansen, Gizem Kilic, Viola Klück, Valerie A.C.M. Koeken, Heidi Lemmers, Simone J.C.F.M. Moorlag, Vera P. Mourits, Jelmer H. van Puffelen, Katrin Rabold, Rutger J. Röring, Diletta Rosati, Helin Tercan, Julia van Tuijl, Jessica Quintin, Reinout van Crevel, Niels P. Riksen, Leo A.B. Joosten, Mihai G. Netea
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100365- (2021)
Summary: A growing number of studies show that innate immune cells can undergo functional reprogramming, facilitating a faster and enhanced response to heterologous secondary stimuli. This concept has been termed “trained immunity.” We outline he
Externí odkaz:
https://doaj.org/article/e0ee4ea53a9e4be785098507068f1cd9
Autor:
Simone J.C.F.M. Moorlag, Yessica Alina Rodriguez-Rosales, Joshua Gillard, Stephanie Fanucchi, Kate Theunissen, Boris Novakovic, Cynthia M. de Bont, Yutaka Negishi, Ezio T. Fok, Lydia Kalafati, Panayotis Verginis, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Ger J.M. Pruijn, Craig Fenwick, Reinout van Crevel, Leo A.B. Joosten, Irma Joosten, Hans Koenen, Musa M. Mhlanga, Dimitri A. Diavatopoulos, Triantafyllos Chavakis, Mihai G. Netea
Publikováno v:
Cell Reports, Vol 33, Iss 7, Pp 108387- (2020)
Summary: The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immuni
Externí odkaz:
https://doaj.org/article/867252fa4e9041d0b4262603d849461e
Autor:
Simone J.C.F.M. Moorlag, Rosanne C. van Deuren, Cornelis H. van Werkhoven, Martin Jaeger, Priya Debisarun, Esther Taks, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Thijs ten Doesschate, Maartje C. Cleophas, Sanne Smeekens, Marije Oosting, Frank L. van de Veerdonk, Leo A.B. Joosten, Jaap ten Oever, Jos W.M. van der Meer, Nigel Curtis, Peter Aaby, Christine Stabell-Benn, Evangelos J. Giamarellos-Bourboulis, Marc Bonten, Reinout van Crevel, Mihai G. Netea
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 5, Pp 100073- (2020)
Summary: Bacille Calmette-Guérin (BCG) induces long-term boosting of innate immunity, termed trained immunity, and decreases susceptibility to respiratory tract infections. BCG vaccination trials for reducing SARS-CoV-2 infection are underway, but c
Externí odkaz:
https://doaj.org/article/8a09f45f0c124dad83ccae252ce19fd1
Autor:
Samuel T. Keating, Laszlo Groh, Charlotte D.C.C. van der Heijden, Hanah Rodriguez, Jéssica C. dos Santos, Stephanie Fanucchi, Jun Okabe, Harikrishnan Kaipananickal, Jelmer H. van Puffelen, Leonie Helder, Marlies P. Noz, Vasiliki Matzaraki, Yang Li, L. Charlotte J. de Bree, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Vera P. Mourits, Jorge Domínguez-Andrés, Marije Oosting, Elianne P. Bulthuis, Werner J.H. Koopman, Musa Mhlanga, Assam El-Osta, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Trained immunity confers a sustained augmented response of innate immune cells to a secondary challenge, via a process dependent on metabolic and transcriptional reprogramming. Because of its previous associations with metabolic and transcri
Externí odkaz:
https://doaj.org/article/582bb41700f44997a86db25e19d81b8d
Autor:
Todia P. Setiabudiawan, Remi K. Reurink, Philip C. Hill, Mihai G. Netea, Reinout van Crevel, Valerie A.C.M. Koeken
Publikováno v:
Med, 3, 6-24
Med, 3, 1, pp. 6-24
Med, 3, 1, pp. 6-24
Bacillus Calmette-Guérin (BCG) was developed exactly 100 years ago, and it is still the only licensed tuberculosis (TB) vaccine and the most frequently administered of all vaccines worldwide. Despite universal vaccination policies in TB-endemic sett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2aa09699080901b913437be89cd573
https://doi.org/10.1016/j.medj.2021.11.006
https://doi.org/10.1016/j.medj.2021.11.006
Autor:
Inge Grondman, Valerie A.C.M. Koeken, Athanasios Karageorgos, Wenchao Li, Nikolaos Antonakos, Bowen Zhang, Georgia Damoraki, Cheng-Jian Xu, Evangelos J. Giamarellos-Bourboulis, Yang Li, Mihai G. Netea
Different immune phenotypes characterize sepsis patients, including hyperinflammation and/or immunosuppression, but the biological mechanisms driving this heterogeneity remain largely unknown. We used single-cell RNA sequencing to profile circulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30e7a1e0ed0c2940a1180a6c3d0d19b7
https://doi.org/10.1101/2023.03.17.23287390
https://doi.org/10.1101/2023.03.17.23287390
