Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Valerie A. Villareal"'
Autor:
Brett D. Lindenbach, Marc-Philipp Pfeil, Paula Montero Llopis, Priscilla L. Yang, Chih-Yun Hsia, Valerie A. Villareal, Dominique J. Burri, Mary A. Rodgers, Lorillee Tallorin
Publikováno v:
The Journal of Biological Chemistry
Many RNA viruses create specialized membranes for genome replication by manipulating host lipid metabolism and trafficking, but in most cases, we do not know the molecular mechanisms responsible or how specific lipids may impact the associated membra
Publikováno v:
ACS Infectious Diseases
Hepatitis C virus (HCV) uniquely affects desmosterol homeostasis by increasing its intracellular abundance and affecting its localization. These effects are important for productive viral replication because the inhibition of desmosterol synthesis ha
Publikováno v:
ACS Chemical Biology. 11:1827-1833
Hepatitis C virus (HCV) increases intracellular desmosterol without affecting the steady-state abundance of other sterols, and the antiviral activity of inhibitors of desmosterol synthesis is suppressed by the addition of exogenous desmosterol. These
Publikováno v:
Antiviral Research. 124:110-121
Lipids are necessary for every step in the replication cycle of hepatitis C virus (HCV) and dengue virus (DENV), members of the family Flaviviridae. Recent studies have demonstrated that discrete steps in the replication cycles of these viruses can b
Autor:
Esperance A. Schaefer, Lee F. Peng, Kathleen E. Corey, Raymond T. Chung, Valerie A. Villareal, Mary A. Rodgers, Priscilla L. Yang
Publikováno v:
Journal of the American Chemical Society. 134:6896-6899
Hepatitis C virus (HCV) infection has been clinically associated with serum lipid abnormalities, yet our understanding of the effects of HCV on host lipid metabolism and conversely the function of individual lipids in HCV replication remains incomple
Transient Weak Protein–Protein Complexes Transfer Heme Across the Cell Wall of Staphylococcus aureus
Autor:
Benfang Lei, Scott A. Robson, Thomas Spirig, Valerie A. Villareal, Robert T. Clubb, Mengyao Liu
Publikováno v:
Journal of the American Chemical Society. 133:14176-14179
Iron is an essential nutrient for the bacterial pathogen Staphylococcus aureus . Heme in hemoglobin (Hb) is the most abundant source of iron in the human body and during infections is captured by S. aureus using iron-regulated surface determinant (Is
Autor:
Chu Kong Liew, Robert T. Clubb, Michael E. Jung, Nuttee Suree, William Thieu, Valerie A. Villareal, Evgeny A. Fadeev, Jeremy J. Clemens
Publikováno v:
Journal of Biological Chemistry. 284:24465-24477
In Gram-positive bacteria, sortase enzymes assemble surface proteins and pili in the cell wall envelope. Sortases catalyze a transpeptidation reaction that joins a highly conserved LPXTG sorting signal within their polypeptide substrate to the cell w
Autor:
Rosemarie M. Pilpa, Melissa Wong, Robert T. Clubb, Valerie A. Villareal, Martin L. Phillips, Evgeny A. Fadeev
Publikováno v:
Journal of Molecular Biology. 360:435-447
During infections the pathogen Staphylococcus aureus procures the essential nutrient iron from its host using iron-regulated surface determinant (Isd) proteins, which scavenge heme bound iron from host hemoproteins. Four Isd proteins are displayed in
Autor:
Eric Stavale, Dominique J. Burri, Mary A. Rodgers, Kelly L. Warfield, Michaela U. Gack, Valerie A. Villareal, Margot Carocci, Stephen M. Hinshaw, Priscilla L. Yang, Rajendra Pilankatta, Natalya P. Maharaj
Publikováno v:
Antimicrobial Agents and Chemotherapy
Dengue virus (DENV), a member of the Flaviviridae family, is a mosquito-borne pathogen and the cause of dengue fever. The increasing prevalence of DENV worldwide heightens the need for an effective vaccine and specific antivirals. Due to the dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8d1637778ae6407ceffc71ce4bf94b
https://europepmc.org/articles/PMC4291433/
https://europepmc.org/articles/PMC4291433/
Publikováno v:
Analytical Letters. 36:451-463
The use of uncoated fused silica capillary columns and hydroxypropylmethyl cellulose (HPMC) in capillary electrophoresis (CE) to separate DNA ladders and plasmids is described. In these studies HPM...