Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Valerie A. Street"'
Publikováno v:
Journal of Biological Chemistry. 286:15278-15286
Mutations within MYO7A can lead to recessive and dominant forms of inherited hearing loss. We previously identified a large pedigree (referred to as the HL2 family) with hearing loss that first impacts the low and mid frequencies segregating a domina
Publikováno v:
Journal of Vestibular Research. 18:51-58
The inner ear contains the developmentally related cochlea and peripheral vestibular labyrinth. Given the similar physiology between these two organs, hearing loss and vestibular dysfunction may be expected to occur simultaneously in individuals segr
Autor:
Valerie A. Street
Publikováno v:
Perspectives on Audiology. 1:14-18
Autor:
George H. Kraft, Thomas D. Bird, W. Seltzer, Gregory T. Carter, G. Meekins, Hillary Lipe, Valerie A. Street
Publikováno v:
Neuromuscular Disorders. 12:643-650
Charcot–Marie–Tooth Hereditary Neuropathy is a heterogeneous syndrome associated with mutations in several different genes including peripheral myelin protein 22, myelin P0, connexin 32, and early growth response 2. There is considerable variabil
Autor:
Linda C. Robinson, Karl W. Broman, Jin Li, Jeremy C. Kallman, Ayaka J. Iwata, Dustin J. Shilling, Carol A. Robbins, Sharon G. Kujawa, Valerie A. Street, Bruce L. Tempel, M. Charles Liberman, Ani Manichaikul
Publikováno v:
Journal of the Association for Research in Otolaryngology : JARO. 15(5)
Noise-induced hearing loss (NIHL) is a prevalent health risk. Inbred mouse strains 129S6/SvEvTac (129S6) and MOLF/EiJ (MOLF) show strong NIHL resistance (NR) relative to CBA/CaJ (CBACa). In this study, we developed quantitative trait locus (QTL) maps
Autor:
Rosalia C. Fonseca, Konrad Noben-Trauth, Jennifer W. McKee-Johnson, Valerie A. Street, Bruce L. Tempel
Publikováno v:
Nature Genetics. 19:390-394
Hearing loss is the most common sensory deficit in humans. Because the auditory systems of mice and humans are conserved, studies on mouse models have predicted several human deafness genes and identified new genes involved in hearing. The deafwaddle
Autor:
Valerie A. Street, Shelly K. Erford, Linda C. Robinson, Bruce L. Tempel, Jennifer W. McKee-Johnson
Publikováno v:
Genomics. 49:371-377
The deafwaddler (dfw) mutation, displaying motor ataxia and profound deafness, arose spontaneously in a C3H/HeJ colony and was mapped previously to distal mouse Chr 6. In this study, a high-resolution genetic map was generated by positioning 10 micro
Autor:
Bruce L. Tempel, Valerie A. Street
Publikováno v:
Genomics. 44:110-117
Mammalian voltage-gated K channel genes have been divided into four subfamilies (Shaker, Shab, Shal, and Shaw) based on their sequence identity and similarity to related genes inDrosophila.Genetic mapping of the voltage-gated K channel genes has show
Autor:
Linda C. Robinson, Bruce L. Tempel, Martha M. Bosma, William S. Agnew, Vasiliki P. Demas, Valerie A. Street, Doras D. Lin, Melissa R. Regan
Publikováno v:
The Journal of Neuroscience. 17:635-645
Theopisthotonos(opt) mutation arose spontaneously in a C57BL/Ks-db2Jcolony and is the only known, naturally occurring allele ofopt. This mutant mouse was first identified based on its ataxic and convulsive phenotype. Genetic and molecular data presen
Autor:
Valerie A. Street, Debra J. Gilbert, Mary B. Migeon, Nancy A. Jenkins, Bruce L. Tempel, Neal G. Copeland, Leslie F. Lock
Publikováno v:
Genomics. 20:354-362
Cloning of the Drosophila Shaker gene established that a neurological phenotype including locomotor dysfunction can be caused by a mutation in a voltage-gated potassium (K) channel gene. Shaker sequences have been used to isolate a large family of re