Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Valerie A. Ashwood"'
Autor:
Valerie A. Ashwood, Christine Julien-Larose, Lakhbir Singh, Russell Andrew Lewthwaite, Scott McCleary, Mark J. Field, Jenny Raphy, M.C. Pritchard, David C. Horwell
Publikováno v:
Journal of Medicinal Chemistry. 44:2276-2285
This paper describes the synthesis and physical and biological effects of introducing different substituents at the alpha-position of the tryptophan containing neurokinin-1 receptor antagonist [(R)-2-(1H-indol-3-yl)-1-methyl-1-((S)-1-phenyl-ethylcarb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc17f5a91816af68130fb3680aa7c7d2
https://doi.org/10.1021/jm010825z
https://doi.org/10.1021/jm010825z
Autor:
N. Suman-Chauhan, Alexander T. McKnight, John Hughes, David C. Horwell, Valerie A. Ashwood, Russell Andrew Lewthwaite, V. Brownhill, M. Higginbottom, C. Webb, Steven Williams, M.C. Pritchard, R. D. Pinnock
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2589-2594
In this paper we describe the development of a novel series of non-peptide, "balanced" neuromedin-B preferring (BB1)/gastrin-releasing peptide preferring (BB2) receptor ligands as exemplified by PD 176252. PD 176252, which exhibits nanomolar affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec09a7b158f405fe45c44519f3e3647
https://doi.org/10.1016/s0960-894x(98)00462-4
https://doi.org/10.1016/s0960-894x(98)00462-4
Autor:
Thomas C. Hamilton, John Morris Evans, Duncan M. Smith, Valerie A. Ashwood, Geoffrey Stemp, David R. Howlett, Frederick Cassidy, Martin C. Coldwell
Publikováno v:
ChemInform. 22
The synthesis and antihypertensive activity of a series of novel 4-(substituted-carbonylamino)-2H-1-benzopyran-3-ols, administered orally to conscious spontaneously hypertensive rats, are described. Optimum activity was observed for compounds with al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f8b3f96c4cc2bfc294d5bd42b1c0841
https://doi.org/10.1002/chin.199108201
https://doi.org/10.1002/chin.199108201
Publikováno v:
Journal of medicinal chemistry. 34(11)
The synthesis and oral antihypertensive activity in conscious spontaneously hypertensive rats of two new series of compounds related to the prototype potassium channel activator cromakalim (1) are described. In the first series, replacement of the be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af27b5612b8829c6e68b2f321c768c4
https://pubmed.ncbi.nlm.nih.gov/1659637
https://pubmed.ncbi.nlm.nih.gov/1659637
Autor:
Kenneth Willcocks, Thomas C. Hamilton, Valerie A. Ashwood, John Morris Evans, David John Nash, Frederick Cassidy, Erol Ali Faruk, Robin Edwin Buckingham, Geoffrey Stemp
Publikováno v:
Journal of Medicinal Chemistry. 29:2194-2201
The synthesis and antihypertensive activity of a series of novel 4-(cyclic amido)-2H-1-benzopyran-3-ols, administered orally to conscious spontaneously hypertensive rats, are described. The effects of lactam ring size, the presence of heteroatoms in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0da6ecf1bad5449953cc1dadffb2302
https://doi.org/10.1021/jm00161a011
https://doi.org/10.1021/jm00161a011