Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Valerie A Wagner"'
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Akademický článek
Cell-specific transcriptome changes in the hypothalamic arcuate nucleus in a mouse deoxycorticosterone acetate-salt model of hypertension
Autor: Valerie A. Wagner, Guorui Deng, Kristin E. Claflin, McKenzie L. Ritter, Huxing Cui, Pablo Nakagawa, Curt D. Sigmund, Lisa L. Morselli, Justin L. Grobe, Anne E. Kwitek
Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)
A common preclinical model of hypertension characterized by low circulating renin is the “deoxycorticosterone acetate (DOCA)-salt” model, which influences blood pressure and metabolism through mechanisms involving the angiotensin II type 1 recept
Externí odkaz: https://doaj.org/article/41540d841a564460be2c9f431689fc37
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2
Akademický článek
Body Composition and Metabolic Changes in a Lyon Hypertensive Congenic Rat and Identification of Ercc6l2 as a Positional Candidate Gene
Autor: Karen C. Clark, Valerie A. Wagner, Katie L. Holl, John J. Reho, Monika Tutaj, Jennifer R. Smith, Melinda R. Dwinell, Justin L. Grobe, Anne E. Kwitek
Publikováno v: Frontiers in Genetics, Vol 13 (2022)
Central obesity is genetically complex, and its exponential increase in the last decades have made it a critical public health issue. The Lyon Hypertensive (LH) rat is a well-characterized hypertensive model that also exhibits spontaneous and profoun
Externí odkaz: https://doaj.org/article/6cbcb81d5ccc4454ad8acdfa47eaf264
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3
Genetic background in the rat affects endocrine and metabolic outcomes of Bisphenol F exposure
Autor: Valerie A Wagner, Katie L Holl, Karen C Clark, John J Reho, Melinda R Dwinell, Hans-Joachim Lehmler, Hershel Raff, Justin L Grobe, Anne E Kwitek
Publikováno v: Toxicological Sciences.
Environmental bisphenol compounds like bisphenol F (BPF) are endocrine disrupting chemicals (EDC) affecting adipose and classical endocrine systems. Genetic factors that influence EDC exposure outcomes are poorly understood and are unaccounted variab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5c91c1c35152e256a8fd50e94fc7a5e
https://doi.org/10.1093/toxsci/kfad046
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4
Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity
Autor: Derek Simonsen, Miriam Velez-Bermudez, Anne E. Kwitek, Hans-Joachim Lehmler, Valerie A Wagner, Kai Wang, Leah C. Solberg Woods, Leslie Carrillo-Sáenz, Karen C Clark, Katie Holl, Justin L. Grobe, Andrew L. Thurman
Publikováno v: Toxicol Sci
Bisphenol F (BPF) is increasingly substituting bisphenol A in manufacturing polycarbonates and consumer products. The cardiometabolic effects of BPF in either humans or model organisms are not clear, and no studies to date have investigated the role
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be4c0e44141d0864f6769b129a0ff07
https://doi.org/10.1093/toxsci/kfab035
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7
Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity
Autor: Valerie A Wagner, Lisa L. Morselli, Guorui Deng, Curt D. Sigmund, Sarah A. Sapouckey, Kirthikaa Balapattabi, Kevin L. Knudtson, Anne E. Kwitek, Huxing Cui, Justin L. Grobe, Kamal Rahmouni
Publikováno v: Hypertension
Prolonged obesity is associated with blunted feeding and thermogenic autonomic responses to leptin, but cardiovascular responses to leptin are maintained. This state of selective leptin resistance is, therefore, proposed to contribute to the pathogen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3bb02ba82760ab1ba288d6b0940536
https://doi.org/10.1161/hypertensionaha.120.15137
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10
Abstract P117: Blood Pressure Heterosis And Genotype-Specific Regulation Of C17h6orf52
Autor: Anne E. Kwitek, Valerie A Wagner, Karen C Clark
Publikováno v: Hypertension. 76
Although blood pressure (BP) is highly heritable, the genetic etiology is complex, and causative genes do not completely explain observed variation. Using the Lyon Hypertensive (LH) rat—a well-characterized polygenic inbred model—we previously id
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::891c403642ecab8d3744896d5df7bb2c
https://doi.org/10.1161/hyp.76.suppl_1.p117
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