Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Valerie A C M, Koeken"'
Autor:
Krista E. van Meijgaarden, Wenchao Li, Simone J. C. F. M. Moorlag, Valerie A. C. M. Koeken, Hans J. P. M. Koenen, Leo A. B. Joosten, Annapurna Vyakarnam, Asma Ahmed, Srabanti Rakshit, Vasista Adiga, Tom H. M. Ottenhoff, Yang Li, Mihai G. Netea, Simone A. Joosten
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Bacillus Calmette-Guèrin - vaccination induces not only protection in infants and young children against severe forms of tuberculosis, but also against non-tuberculosis related all-cause mortality. To delineate different factors influencing
Externí odkaz:
https://doaj.org/article/2176553ccf2643cf9ec6fb719ffcf68d
Autor:
Martijn Zoodsma, Aline H. de Nooijer, Inge Grondman, Manoj Kumar Gupta, Agnes Bonifacius, Valerie A. C. M. Koeken, Emma Kooistra, Gizem Kilic, Ozlem Bulut, Nina Gödecke, Nico Janssen, Matthijs Kox, Jorge Domínguez-Andrés, Adriaan J. van Gammeren, Anton A. M. Ermens, Andre J. A. M. van der Ven, Peter Pickkers, Rainer Blasczyk, Georg M. N. Behrens, Frank L. van de Veerdonk, Leo A. B. Joosten, Cheng-Jian Xu, Britta Eiz-Vesper, Mihai G. Netea, Yang Li
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic is caused by the highly infectious Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). There is an urgent need for biomarkers that will help in better stratification of patients and c
Externí odkaz:
https://doaj.org/article/bf3709bd973c499892bbf04526a3acf9
Autor:
Martin Stražar, Vera P. Mourits, Valerie A. C. M. Koeken, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Leo A. B. Joosten, Reinout van Crevel, Hera Vlamakis, Mihai G. Netea, Ramnik J. Xavier
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)
Abstract Background The bacillus Calmette-Guérin (BCG) vaccine protects against tuberculosis and heterologous infections but elicits high inter-individual variation in specific and nonspecific, or trained, immune responses. While the gut microbiome
Externí odkaz:
https://doaj.org/article/55e912bb35d948619f632bcf4e2b1b3d
Autor:
Valerie A C M Koeken, Cancan Qi, Vera P Mourits, L Charlotte J de Bree, Simone J C F M Moorlag, Vidhisha Sonawane, Heidi Lemmers, Helga Dijkstra, Leo A B Joosten, Arjan van Laarhoven, Cheng-Jian Xu, Reinout van Crevel, Mihai G Netea, Yang Li
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001765 (2022)
The antituberculosis vaccine Bacillus Calmette-Guérin (BCG) induces nonspecific protection against heterologous infections, at least partly through induction of innate immune memory (trained immunity). The amplitude of the response to BCG is variabl
Externí odkaz:
https://doaj.org/article/173cefc026c34139a0fea4c66baf3183
Autor:
Xiaojing Chu, Martin Jaeger, Joep Beumer, Olivier B. Bakker, Raul Aguirre-Gamboa, Marije Oosting, Sanne P. Smeekens, Simone Moorlag, Vera P. Mourits, Valerie A. C. M. Koeken, Charlotte de Bree, Trees Jansen, Ian T. Mathews, Khoi Dao, Mahan Najhawan, Jeramie D. Watrous, Irma Joosten, Sonia Sharma, Hans J. P. M. Koenen, Sebo Withoff, Iris H. Jonkers, Romana T. Netea-Maier, Ramnik J. Xavier, Lude Franke, Cheng-Jian Xu, Leo A. B. Joosten, Serena Sanna, Mohit Jain, Vinod Kumar, Hans Clevers, Cisca Wijmenga, Mihai G. Netea, Yang Li
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)
Abstract Background Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors. Result We systematically investigate circulating metabolites in
Externí odkaz:
https://doaj.org/article/c356b25dd4854dcbb5ff8d2fda446129
Autor:
Yunus Kuijpers, Xiaojing Chu, Martin Jaeger, Simone J. C. F. M. Moorlag, Valerie A. C. M. Koeken, Bowen Zhang, Aline de Nooijer, Inge Grondman, Manoj Kumar Gupta, Nico Janssen, Vera P. Mourits, L. Charlotte J. de Bree, Quirijn de Mast, Frank L. van de Veerdonk, Leo A. B. Joosten, Yang Li, Mihai G. Netea, Cheng-Jian Xu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Recent genome-wide association studies (GWASs) of COVID-19 patients of European ancestry have identified genetic loci significantly associated with disease severity. Here, we employed the detailed clinical, immunological and multi-omics dataset of th
Externí odkaz:
https://doaj.org/article/0b35664509264d24882986c6d51eaca4
Autor:
Priya A. Debisarun, Katharina L. Gössling, Ozlem Bulut, Gizem Kilic, Martijn Zoodsma, Zhaoli Liu, Marina Oldenburg, Nadine Rüchel, Bowen Zhang, Cheng-Jian Xu, Patrick Struycken, Valerie A. C. M. Koeken, Jorge Domínguez-Andrés, Simone J. C. F. M. Moorlag, Esther Taks, Philipp N. Ostermann, Lisa Müller, Heiner Schaal, Ortwin Adams, Arndt Borkhardt, Jaap ten Oever, Reinout van Crevel, Yang Li, Mihai G. Netea
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
Non-specific protective effects of certain vaccines have been reported, and long-term boosting of innate immunity, termed trained immunity, has been proposed as one of the mechanisms mediating these effects. Several epidemiological studies suggested
Externí odkaz:
https://doaj.org/article/bb503210c907406587f8ee851b581eb5
Autor:
Gizem Kilic, Ozlem Bulut, Martin Jaeger, Rob ter Horst, Valerie A. C. M. Koeken, Simone J. C. F. M. Moorlag, Vera P. Mourits, Charlotte de Bree, Jorge Domínguez-Andrés, Leo A. B. Joosten, Mihai G. Netea
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Male sex and old age are risk factors for COVID-19 severity, but the underlying causes are unknown. A possible explanation for this might be the differences in immunological profiles in males and the elderly before the infection. With this in mind, w
Externí odkaz:
https://doaj.org/article/659d0e3a1f5440459e7f1fbbad9c4fb6
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The immune system plays a vital role in health and disease, and is regulated through a complex interactive network of many different immune cells and mediators. To understand the complexity of the immune system, we propose to apply a multi-omics appr
Externí odkaz:
https://doaj.org/article/0a3eef0a77354845a6978dcb953435c2
Autor:
Vera P. Mourits, Valerie A. C. M. Koeken, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Wern Cui Chu, Xiaoli Xu, Helga Dijkstra, Heidi Lemmers, Leo A. B. Joosten, Yue Wang, Reinout van Crevel, Mihai G. Netea
Publikováno v:
Journal of Immunology Research, Vol 2020 (2020)
BCG vaccination protects not only against tuberculosis but also against heterologous infections. This effect differs between individuals, yet the factors responsible for this variation are unknown. BCG-induced nonspecific protection is, at least part
Externí odkaz:
https://doaj.org/article/58896731c6ec463baa60fcef2646f1d7