A Vault-Encapsulated Enzyme Approach for Efficient Degradation and Detoxification of Bisphenol A and Its Analogues

Autor: Patrick Allard, Shaily Mahendra, Leonard H. Rome, Yichang Chen, Valerie A. Kickhoefer, Meng Wang

Publikováno v: ACS Sustain Chem Eng
ACS sustainable chemistry & engineering, vol 7, iss 6

We report an effective and environmentally sustainable water treatment approach using enzymes encapsulated in biogenic vault nanoparticles. Manganese peroxidase (MnP), whose stability was remarkably extended by encapsulating into vaults, rapidly cata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74491b8c18c64181bbb9cb5ef7e18ac0
https://pubmed.ncbi.nlm.nih.gov/36419408

Intratumor injection of CCL21-coupled vault nanoparticles is associated with reduction in tumor volume in an in vivo model of glioma

Autor: Sergey Mareninov, Carlito Lagman, Natalie E. Barnette, Prasanth Romiyo, Panayiotis E. Pelargos, Thien Nguyen, Isaac Yang, John P. Sheppard, Leonard H. Rome, Valerie A. Kickhoefer, Cheng Hao Jacky Chen, Brittany L. Voth, William H. Yong, Nikhilesh S. Bhatt, Lawrance K. Chung

Publikováno v: Journal of Neuro-Oncology. 147:599-605

Glioblastoma (GBM) is the most common and malignant primary adult brain tumor. Current care includes surgical resection, radiation, and chemotherapy. Recent clinical trials for GBM have demonstrated extended survival using interventions such as tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf7f9194671f14f6b3300c25ec9b741
https://doi.org/10.1007/s11060-020-03479-8

Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones

Autor: Bastiaan P. Krom, Nicholas T. Jacob, Kim D. Janda, Josep Rayo, Gunnar F. Kaufmann, Benjamin F. Cravatt, Herman S. Overkleeft, Alexander Aranovich, Michael M. Meijler, Erik A.C. Wiemer, Bogdan I. Florea, Valerie A. Kickhoefer, Manikandan Thangaraj, Rambabu Dandela, Tsaffrir Zor, John C. Mathison, Richard J. Ulevitch, Rachel Gregor, Orna Ernst, Sergey Malitsky, Luba Dubinsky, Vladimir V. Kravchenko, Eran Barash, Leonard H. Rome, Alex Yashkin

Publikováno v: Rayo, J, Gregor, R, Jacob, N T, Dandela, R, Dubinsky, L, Yashkin, A, Aranovich, A, Thangaraj, M, Ernst, O, Barash, E, Malitsky, S, Florea, B I, Krom, B P, Wiemer, E A C, Kickhoefer, V A, Rome, L H, Mathison, J C, Kaufmann, G F, Overkleeft, H S, Cravatt, B F, Zor, T, Janda, K D, Ulevitch, R J, Kravchenko, V V & Meijler, M M 2021, ' Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 12, e2012529118 . https://doi.org/10.1073/pnas.2012529118
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 12
Proceedings of the National Academy of Sciences of the United States of America, 118(12):e2012529118. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 118(12):e2012529118. National Acad Sciences
Proceedings of the National Academy of Sciences of the United States of America, 118(12), e2012529118

© 2021 National Academy of Sciences. All rights reserved.The major vault protein (MVP) mediates diverse cellular responses, including cancer cell resistance to chemotherapy and protection against inflammatory responses to Pseudomonas aeruginosa. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de316d4ca8b30affe8732f94f6cea422
https://doi.org/10.1073/pnas.2012529118

Synthesis and assembly of human vault particles in yeast

Autor: O. Foellmer, Shaily Mahendra, Valerie A. Kickhoefer, Meng Wang, Leonard H. Rome

Publikováno v: Biotechnology and Bioengineering. 115:2941-2950

Vault particles are the largest naturally occurring ribonucleoprotein complexes found in the cytoplasm. In all 78 copies of major vault protein (MVP) assemble on polyribosome templates, forming recombinant vault particles, which are of great interest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e85ac8c926fc34d5db386de8c636005
https://doi.org/10.1002/bit.26825

A vault nanoparticle vaccine induces protective mucosal immunity.

Autor: Cheryl I Champion, Valerie A Kickhoefer, Guangchao Liu, Raymond J Moniz, Amanda S Freed, Liisa L Bergmann, Dana Vaccari, Sujna Raval-Fernandes, Ann M Chan, Leonard H Rome, Kathleen A Kelly

Publikováno v: PLoS ONE, Vol 4, Iss 4, p e5409 (2009)

Generation of robust cell-mediated immune responses at mucosal surfaces while reducing overall inflammation is a primary goal for vaccination. Here we report the use of a recombinant nanoparticle as a vaccine delivery platform against mucosal infecti

Externí odkaz: https://doaj.org/article/ecb344c5dfc247efb910da8e1891ecd7