Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia

Autor: Mattias Hofmans, Tim Lammens, Barbara Depreter, Ying Wu, Miriam Erlacher, Aurélie Caye, Hélène Cavé, Christian Flotho, Valerie de Haas, Charlotte M. Niemeyer, Jan Stary, Filip Van Nieuwerburgh, Dieter Deforce, Wouter Van Loocke, Pieter Van Vlierberghe, Jan Philippé, Barbara De Moerloose

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract Juvenile myelomonocytic leukemia (JMML) treatment primarily relies on hematopoietic stem cell transplantation and results in long-term overall survival of 50–60%, demonstrating a need to develop novel treatments. Dysregulation of the non-c

Externí odkaz: https://doaj.org/article/0585c9174d894b83a10e9c9210ba9f53

CircRNAs Dysregulated in Juvenile Myelomonocytic Leukemia: CircMCTP1 Stands Out

Autor: Anna Dal Molin, Mattias Hofmans, Enrico Gaffo, Alessia Buratin, Hélène Cavé, Christian Flotho, Valerie de Haas, Charlotte M. Niemeyer, Jan Stary, Pieter Van Vlierberghe, Jan Philippé, Barbara De Moerloose, Geertruij te Kronnie, Silvia Bresolin, Tim Lammens, Stefania Bortoluzzi

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2021)

Juvenile myelomonocytic leukemia (JMML), a rare myelodysplastic/myeloproliferative neoplasm of early childhood, is characterized by clonal growth of RAS signaling addicted stem cells. JMML subtypes are defined by specific RAS pathway mutations and di

Externí odkaz: https://doaj.org/article/ef46116954d54794987bb5e59f8888b4

Second allogeneic stem cell transplantation can rescue a significant proportion of patients with JMML relapsing after first allograft

Autor: Luca Vinci, Christian Flotho, Peter Noellke, Dirk Lebrecht, Riccardo Masetti, Valerie de Haas, Barbara De Moerloose, Michael Dworzak, Henrik Hasle, Tayfun Güngör, Jan Starý, Dominik Turkiewicz, Marek Ussowicz, Cristina Diaz de Heredia, Jochen Buechner, Kirsi Jahnukainen, Krisztian Kallay, Ivana Bodova, Owen P. Smith, Marco Zecca, Dorine Bresters, Peter Lang, Tania Nicole Masmas, Roland Meisel, Herbert Pichler, Miriam Erlacher, Gudrun Göhring, Franco Locatelli, Brigitte Strahm, Charlotte M. Niemeyer, Ayami Yoshimi

Publikováno v: Scientia
Vinci, L, Flotho, C, Noellke, P, Lebrecht, D, Masetti, R, de Haas, V, De Moerloose, B, Dworzak, M, Hasle, H, Güngör, T, Starý, J, Turkiewicz, D, Ussowicz, M, de Heredia, C D, Buechner, J, Jahnukainen, K, Kallay, K, Bodova, I, Smith, O P, Zecca, M, Bresters, D, Lang, P, Masmas, T N, Meisel, R, Pichler, H, Erlacher, M, Göhring, G, Locatelli, F, Strahm, B, Niemeyer, C M & Yoshimi, A 2023, ' Second allogeneic stem cell transplantation can rescue a significant proportion of patients with JMML relapsing after first allograft ', Bone Marrow Transplantation, vol. 58, no. 5, pp. 607-609 . https://doi.org/10.1038/s41409-023-01942-4

Myeloproliferative disease; Paediatrics Enfermedad mieloproliferativa; Pediatría Malaltia mieloproliferativa; Pediatria Open Access funding enabled and organized by Projekt DEAL.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e05658aa731f44e16c1b8bc70fa6417
https://doi.org/10.1038/s41409-023-01942-4

Evaluation of the pharmacokinetics of prednisolone in paediatric patients with acute lymphoblastic leukaemia treated according to Dutch Childhood Oncology Group protocols and its relation to treatment response

Autor: C. Michel Zwaan, Gertjan J.L. Kaspers, Rob Pieters, Marc Bierings, Sebastiaan D. T. Sassen, D Maroeska W W Te Loo, Wim J. E. Tissing, Inge M. van der Sluis, Ron A. A. Mathôt, Valerie de Haas, Cor van den Bos

Publikováno v: British journal of haematology, 194(2), 423-432. Wiley-Blackwell
British Journal of Haematology, 194(2), 423-432. Wiley
British Journal of Haematology, 194(2), 423-432. Wiley-Blackwell Publishing Ltd
British Journal of Haematology
Sassen, S D T, Mathôt, R A A, Pieters, R, de Haas, V, Kaspers, G J L, van den Bos, C, Tissing, W J E, te Loo, D M W W, Bierings, M B, van der Sluis, I M & Zwaan, C M 2021, ' Evaluation of the pharmacokinetics of prednisolone in paediatric patients with acute lymphoblastic leukaemia treated according to Dutch Childhood Oncology Group protocols and its relation to treatment response ', British Journal of Haematology, vol. 194, no. 2, pp. 423-432 . https://doi.org/10.1111/bjh.17572
British Journal of Haematology, 194(2), 423-432. Wiley-Blackwell

Summary Glucocorticoids form the backbone of paediatric acute lymphoblastic leukaemia (ALL) treatment. Many studies have been performed on steroid resistance; however, few studies have addressed the relationship between dose, concentration and clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76650013e151bdb89b0106441b6a584
https://pure.eur.nl/en/publications/da478205-48f0-4fe8-81b3-4b75924fdb91

Dutch ALL11 Study: Improved Outcome for Acute Lymphoblastic Leukemia By Prolonging Therapy for IKZF1 Deletion and Decreasing Therapy for ETV6::RUNX1, Down Syndrome and Prednisone Poor Responders

Autor: Rob Pieters, Hester A. De Groot-Kruseman, Femke Verwer, Merian van Overveld, Edwin Sonneveld, Marta Fiocco, Vincent H.J. van der Velden, Berna Beverloo, Marc Bierings, Valerie De Haas, Peter M. Hoogerbrugge, Inge M. Van Der Sluis, Wim J.E. Tissing, Margreet Veening, Judith M. Boer, Monique L. den Boer

Publikováno v: Blood. 140:519-520

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::757d796690c25fd13a841a0a38ab387a
https://doi.org/10.1182/blood-2022-165931