Výsledky vyhledávání - "Valerie, Stewart"

Oregon’s approach to leveraging system-level data to guide a social determinants of health-informed approach to children’s healthcare

Autor: Deepti Shinde, Christopher W Coon, Colleen Reuland, Aaron C Cochran, Valerie Stewart, Jon Collins, Lydia Chiang, Dana Hargunani

Publikováno v: BMJ Innovations. 7:18-25

BackgroundChildren’s health and healthcare use are impacted by both medical conditions and social factors, such as their home and community environment. As healthcare systems manage a pediatric population, information about these factors is crucial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b84afa1daf60a48bc5727c0612884e38
https://doi.org/10.1136/bmjinnov-2020-000452

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Nucleome Dynamics during Retinal Development

Autor: Xiang Chen, John Easton, Issam Al Diri, Daniel Putnam, Michael A. Dyer, Lyra Griffiths, Beisi Xu, Marc Valentine, Dianna A. Johnson, Shondra Miller, Marybeth S. Lupo, Sharon Frase, Jackie L. Norrie, Jiakun Zhang, Ying Shao, Xin Zhou, Victoria Honnell, Valerie Stewart

Publikováno v: Neuron

More than 8,000 genes are turned on or off as progenitor cells produce the 7 classes of retinal cell types during development. Thousands of enhancers are also active in the developing retinae, many having features of cell- and developmental stage-spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a62ad26d97bc117c24d5a29fced5f07
https://pubmed.ncbi.nlm.nih.gov/31493975

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The Nucleome of Developing Murine Rod Photoreceptors

Autor: Abbas Shirinifard, Issam Al Diri, Dianna Johnson, Michael A. Dyer, Daniel Putnam, Marybeth S. Lupo, Jiakun Zhang, Sharon Frase, Shondra Miller, Beisi Xu, John Easton, Jackie L. Norrie, Valerie Stewart, Xiang Chen, Ying Shao, Marc Valentine, Lyra Griffiths, Victoria Honnell

The nuclei of rod photoreceptors in mice and other nocturnal species have an unusual inverted chromatin structure: the heterochromatin is centrally located to help focus light and improve photosensitivity. To better understand this unique nuclear org

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcc49bd83f0e20fbbf7b270746cd811
https://doi.org/10.1101/369702

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Truncated immunoglobulin Dμ causes incomplete developmental progression of RAG-deficient pro-B cells

Autor: Valerie Stewart, Albert C. Shaw, Frederick W. Alt, Faith Young, Barbara A. Malynn

Publikováno v: Molecular Immunology. 38:547-556

Early stages of B cell development are dependent on the expression of a pre-B cell receptor (BCR), composed of a mu heavy chain (HC) in association with surrogate light chain (SLC) proteins and the signaling molecules, Igalpha and Igbeta. During the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc0e37afdef27575f32173b37471f97
https://doi.org/10.1016/s0161-5890(01)00085-2

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A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon

Autor: Shaoguang Li, Frederick W. Alt, Valerie Stewart, Andrea Bottaro, Jue Zhang

Publikováno v: The EMBO Journal. 12:3529-3537

LPS stimulation of B lymphocytes induces germline transcription of and subsequent switching to the gamma 2b gene. Mature germline transcripts contain an I exon (non-coding) spliced to the C gamma 2b exons. To investigate the role of germline transcri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e506982d10adc6a10821d185b7b164a
https://doi.org/10.1002/j.1460-2075.1993.tb06027.x

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Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells

Autor: Jianzhu Chen, Tyler Jacks, James R Gorman, Bart O. Williams, Valerie Stewart, Frederick W. Alt

Publikováno v: Current Biology. 3:405-413

Background: Mice homozygous for a loss-of-function mutation of the recombination-activating gene-2 ( RAG 2 ), which is required for the rearrangement of antigen receptor genes, do not produce mature B and T lymphocytes. But chimeric mice that result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce9e0c45010a54e82081a7e4d4beb5b
https://doi.org/10.1016/0960-9822(93)90347-q

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Structure and Expression of Germ Line Immunoglobulin Heavy-Chain ε Transcripts: Interleukin-4 Plus Lipopolysaccharide-Directed Switching to Cε

Autor: Paul B. Rothman, Frederick W. Alt, S C Li, Robert L. Coffman, Valerie Stewart, Yunn-Yi Chen, Stuart Lutzker

Publikováno v: Molecular and Cellular Biology. 10:1672-1679

We have isolated cDNA clones complementary to a truncated immunoglobulin heavy-chain C epsilon RNA transcript previously found to be induced in B lymphoid cells by treatment with lipopolysaccharide (LPS) combined with interleukin-4 (IL-4). We demonst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f742391d693ecbf0d7e5b73c7d0e68
https://doi.org/10.1128/mcb.10.4.1672-1679.1990

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Structure and expression of germline immunoglobulin γ3 heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching

Autor: Frederick W. Alt, Valerie Stewart, Beverly Gorham, Stuart Lutzker, Robert L. Coffman, Paul B. Rothman

Publikováno v: International Immunology. 2:621-627

We have characterized the structure and expression of transcripts synthesized from the murine germline immunoglobulin gamma 3 heavy chain gene in certain B-lineage cells. The transcripts initiate upstream of the switch gamma 3 region, generating a 5'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a30bd2d8a95316e46fd52cc8b13089
https://doi.org/10.1093/intimm/2.7.621

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