Zobrazeno 1 - 10
of 326
pro vyhledávání: '"Valerie, Speirs"'
Autor:
Chiara Galloni, Teklu Egnuni, Safoura Zahed Mohajerani, Jiaqi Ye, Sibylle Mittnacht, Valerie Speirs, Mihaela Lorger, Georgia Mavria
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The role of endothelial cells in promoting cancer cell extravasation to the brain during the interaction of cancer cells with the vasculature is not well characterised. We show that brain endothelial cells activate EGFR signalling in triple-
Externí odkaz:
https://doaj.org/article/cd26aee6a2a548fb9ca20940a8ec9c7a
Autor:
Sophie E. Roberts, Heather L. Martin, Danah Al-Qallaf, Anna A. Tang, Christian Tiede, Thembaninkosi G. Gaule, Albor Dobon-Alonso, Ross Overman, Sachin Shah, Hadrien Peyret, Keith Saunders, Robin Bon, Iain W. Manfield, Sandra M. Bell, George P. Lomonossoff, Valerie Speirs, Darren C. Tomlinson
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110461- (2024)
Summary: Monoclonal antibodies have revolutionized therapies, but non-immunoglobulin scaffolds are becoming compelling alternatives owing to their adaptability. Their ability to be labeled with imaging or cytotoxic compounds and to create multimeric
Externí odkaz:
https://doaj.org/article/afbbfa1f915d4d408b05c261d3880b47
Autor:
Subarnarekha Chatterji, Jan Moritz Niehues, Marko van Treeck, Chiara Maria Lavinia Loeffler, Oliver Lester Saldanha, Gregory Patrick Veldhuizen, Didem Cifci, Zunamys Itzell Carrero, Rasha Abu-Eid, Valerie Speirs, Jakob Nikolas Kather
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Breast cancer prognosis and management for both men and women are reliant upon estrogen receptor alpha (ERα) and progesterone receptor (PR) expression to inform therapy. Previous studies have shown that there are sex-specific binding charac
Externí odkaz:
https://doaj.org/article/bdd8711bc54a4bd2b2acb26413598361
Autor:
Anca Tutuianu, Chinedu A Anene, Mikayla Shelton, Valerie Speirs, Donald C Whitelaw, Joanne Thorpe, Wayne Roberts, James R Boyne
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0304870 (2024)
The underlying causes of breast cancer are diverse, however, there is a striking association between type 2 diabetes and poor patient outcomes. Platelet activation is a common feature of both type 2 diabetes and breast cancer and has been implicated
Externí odkaz:
https://doaj.org/article/6ce5d6597a2440babcf9c72ede1382a4
Autor:
Kyle K. Greenland, Kathryn A. F. Pennel, Giorgia Cioccoloni, Connor Rogerson, Francis M. Barnieh, Valerie Speirs
Publikováno v:
Biology Open, Vol 12, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/2128bfe711f14e158b941a52d3621042
Autor:
Ashley Sunderland, Jennifer Williams, Tereza Andreou, Nora Rippaus, Christopher Fife, Fiona James, Yolanda Dyah Kartika, Valerie Speirs, Ian Carr, Alastair Droop, Mihaela Lorger
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Exit of quiescent disseminated cancer cells from dormancy is thought to be responsible for metastatic relapse and a better understanding of dormancy could pave the way for novel therapeutic approaches. We used an in vivo model of triple negative brea
Externí odkaz:
https://doaj.org/article/edd0e15041a74a878fd5719f0821bcfc
Autor:
Guerman Molostvov, Mariam Gachechiladze, Abeer M. Shaaban, Steven Hayward, Isaac Dean, Irundika H.K. Dias, Nahla Badr, Irini Danial, Fiyaz Mohammed, Vera Novitskaya, Liliia Paniushkina, Valerie Speirs, Andrew Hanby, Irina Nazarenko, David R. Withers, Steven van Laere, Heather M. Long, Fedor Berditchevski
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112207- (2023)
Summary: The immune microenvironment in breast cancer (BCa) is controlled by a complex network of communication between various cell types. Here, we find that recruitment of B lymphocytes to BCa tissues is controlled via mechanisms associated with ca
Externí odkaz:
https://doaj.org/article/d52dec9b7f7b4b208e542f1913acb799
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0293633 (2023)
UK medical and dental school curricula limit opportunities for students to gain experience in research. This parallels a decline in the number of clinical academics. To address this at grass roots level, we organised and arranged a residential summer
Externí odkaz:
https://doaj.org/article/df2c2faeb2004d528a4c8ce079eed0d4
Autor:
Peng Liu, Sophie Roberts, James T Shoemaker, Jelena Vukasinovic, Darren C Tomlinson, Valerie Speirs
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0283044 (2023)
3D cell culture models of cancer are currently being developed to recapitulate in vivo physiological conditions and to assess therapeutic responses. However, most models failed to incorporate the biochemical and biophysical stimuli from fluid flow. I
Externí odkaz:
https://doaj.org/article/a1f3233e463f4959a479de1b5e0033e3
Autor:
Tim H Ward, Duncan C Gilbert, George Higginbotham, Chris M Morris, Valerie Speirs, Nicola J Curtin
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 1, Pp 3-13 (2022)
Abstract Half of all cancer patients receive radiotherapy, which makes a substantial contribution to their long‐term disease control/cure. There are significant inter‐patient differences in response, both in terms of efficacy and toxicity (freque
Externí odkaz:
https://doaj.org/article/09dae4cbd5104361b79da6053436b26d