Inference of an Integrative, Executable Network for Rheumatoid Arthritis Combining Data-Driven Machine Learning Approaches and a State-of-the-Art Mechanistic Disease Map

Autor: Quentin, Miagoux, Vidisha, Singh, Dereck, de Mézquita, Valerie, Chaudru, Mohamed, Elati, Elisabeth, Petit-Teixeira, Anna, Niarakis

Publikováno v: Journal of Personalized Medicine
Volume 11
Issue 8
Journal of Personalized Medicine, 2021, 11 (8), pp.785. ⟨10.3390/jpm11080785⟩
Journal of Personalized Medicine, MDPI, 2021, 11 (8), pp.785. ⟨10.3390/jpm11080785⟩
Journal of Personalized Medicine, Vol 11, Iss 785, p 785 (2021)

International audience; Rheumatoid arthritis (RA) is a multifactorial, complex autoimmune disease that involves various genetic, environmental, and epigenetic factors. Systems biology approaches provide the means to study complex diseases by integrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5d06c0a75ec5350cea89eb1c7330f773

Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma‐prone families from three continents

Autor: Goldstein, A. M., Chan, M., Harland, M., Hayward, N. K., Demenais, F., Bishop, D. T., Azizi, E., Bergman, W., Bianchi, Giovanna, Bruno, William, Calista, D., CANNON ALBRIGHT, L. A., Chaudru, V., Chompret, A., Cuellar, F., Elder, D. E., Ghiorzo, Paola, Gillanders, E. M., Gruis, N. A., Jhansson, Dhogg, Holland, E. A., Kanetsky, PETER A., Kefford, R. F., Landi, Mt, Lang, Ju, Leachman, S. A., Mackie, R. M., Magnusson, V., Mann, G. J., NEWTON BISHOP, J., Palmer, J. M., Spuig, PUIG BUTILLE, J. A., Stark, M., Tsao, H., Tucker, M. A., Whitaker, L., Yakobson, E., Malvehy, J., Badenas, C., Cervera, R., Francisco, Cuellar, Rosa, Marti´, JOAN BRUNET VIDAL, Guang, Yang, Nicholas, Martin, David, Whiteman, Adele, Green, Joanne, Aitken, Paola, Minghetti, Mantelli, Michela, Pastorino, Lorenza, Nasti, Sabina, Gargiulo, Sara, Sara, Gliori, Sushila, Mistry, JULIETTE RANDERSON MOOR, Wilma, Bergman, TER HUURNE, JEANET A. C., CLASINE VAN DER DRIFT, LENY VAN MOURIK, COBY OUT LUITING, FRANS VAN NIEUWPOORT, Valerie, Chaudru, Agnes, Chompret, Caroline, Kanengiesser, Michel, J. L., Grange, F., Sassolas, B., Limacher, J. M., Couillet, D., Truchetet, F., Cesarini, J. P., Boitier, F., CHEVRANT BRETON, J., Lasset, C., Longy, M., Joly, P., BASSET SEGUIN, N., Lesimple, T., Dugast, C., Arupa, Ganguly, Michael, Ming, PATRICIA VAN BELLE, Anton, Platz, Suzanne, Egyhazi, Rainer, Tuominen, Diana, Linden, Helen, Schmid, Alon, Scope, Felix, Pavlotsky, Eitan, Friedman, Mark, Eliason

BACKGROUND: The major factors individually reported to be associated with an increased frequency of CDKN2A mutations are increased number of patients with melanoma in a family, early age at melanoma diagnosis, and family members with multiple primary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91cfc5ee3b3040ec3c1722872069b35
https://europepmc.org/articles/PMC2598064/