Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Valerian Grote"'
Publikováno v:
Engineering, Vol 26, Iss , Pp 132-150 (2023)
As the roles of glycans in health and disease continue to be unraveled, it is becoming apparent that glycans’ immense complexity cannot be ignored. To fully delineate glycan structures, we developed an integrative approach combining a set of cost-e
Externí odkaz:
https://doaj.org/article/79d6f955893c4879851bc7d1e77f8b07
Autor:
René G Feichtinger, Andreas Hüllen, Andreas Koller, Dieter Kotzot, Valerian Grote, Erdmann Rapp, Peter Hofbauer, Karin Brugger, Christian Thiel, Johannes A Mayr, Saskia B Wortmann
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 9, Pp n/a-n/a (2021)
Abstract Congenital disorders of glycosylation are a genetically and phenotypically heterogeneous family of diseases affecting the co‐ and posttranslational modification of proteins. Using exome sequencing, we detected biallelic variants in GFUS (N
Externí odkaz:
https://doaj.org/article/699449adff8e4925a226be31d77dff32
Autor:
Johannes Ruhnau, Valerian Grote, Mariana Juarez-Osorio, Dunja Bruder, Reza Mahour, Erdmann Rapp, Thomas F. T. Rexer, Udo Reichl
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
The baculovirus-insect cell expression system is readily utilized to produce viral glycoproteins for research as well as for subunit vaccines and vaccine candidates, for instance against SARS-CoV-2 infections. However, the glycoforms of recombinant p
Externí odkaz:
https://doaj.org/article/82cfef654b874fb5979010a55ca622a8
Autor:
Thomas Fischöder, Samanta Cajic, Valerian Grote, Raphael Heinzler, Udo Reichl, Matthias Franzreb, Erdmann Rapp, Lothar Elling
Publikováno v:
Molecules, Vol 24, Iss 19, p 3482 (2019)
Several health benefits, associated with human milk oligosaccharides (HMOS), have been revealed in the last decades. Further progress, however, requires not only the establishment of a simple “routine” method for absolute quantification of comple
Externí odkaz:
https://doaj.org/article/c0d6ea3adb3d498787aba7d6f3b11329
Autor:
Hermann J. Hütte, Birgit Tiemann, Aleksandra Shcherbakova, Valerian Grote, Marcus Hoffmann, Lorenzo Povolo, Mark Lommel, Sabine Strahl, Sergey Y. Vakhrushev, Erdmann Rapp, Falk F. R. Buettner, Adnan Halim, Anne Imberty, Hans Bakker
Publikováno v:
Hütte, H J, Tiemann, B, Shcherbakova, A, Grote, V, Hoffmann, M, Povolo, L, Lommel, M, Strahl, S, Vakhrushev, S Y, Rapp, E, Buettner, F F R, Halim, A, Imberty, A & Bakker, H 2022, ' A Bacterial Mannose Binding Lectin as a Tool for the Enrichment of C-and O-Mannosylated Peptides ', Analytical Chemistry, vol. 94, no. 20, pp. 7329–7338 . https://doi.org/10.1021/acs.analchem.2c00742
Mass spectrometry (MS) easily detects C-mannosylated peptides from purified proteins but not from complex biological samples. Enrichment of specific glycopeptides by lectin affinity prior to MS analysis has been widely applied to support glycopeptide
Autor:
Erdmann Rapp, Valerian Grote, Simon Boecker, Marcus Hoffmann, Udo Reichl, Robert Kottler, Katja Bettenbrock, Anna Schildbach, Markus Pietzsch, Sebastian Tischlik, Christin Bergmann, Thomas Rexer, Reza Mahour, Lisa Wenzel
Publikováno v:
Journal of Biotechnology. 322:54-65
A wide range of glycoproteins can be recombinantly expressed in aglycosylated forms in bacterial and cell-free production systems. To investigate the effect of glycosylation of these proteins on receptor binding, stability, efficacy as drugs, pharmac
Autor:
Steffen Klamt, Udo Reichl, Pia Grimpe, Valerian Grote, Reza Mahour, Andreas Seidel-Morgenstern, Simon Boecker, Ju Weon Lee, Thomas Rexer
Publikováno v:
ChemBioChem
High costs and low availability of UDP-galactose hampers the enzymatic synthesis of valuable oligosaccharides such as human milk oligosaccharides. Here, we report the development of a platform for the scalable, biocatalytic synthesis and purification
Autor:
Clara Becker, Erdmann Rapp, Kaisa Pakari, Valerian Grote, Thomas Thumberger, Thomas Ruppert, Joachim Wittbrodt, Marcus Hoffmann, Roman Sakson, Sevinç Gücüm, Lars Beedgen, Christian Thiel
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
Development
article-version (VoR) Version of Record
Development
Defects in the evolutionarily conserved protein-glycosylation machinery during embryonic development are often fatal. Consequently, congenital disorders of glycosylation (CDG) in human are rare. We modelled a putative hypomorphic mutation described i
Autor:
Joachim Wittbrodt, Thomas Ruppert, Christian Thiel, Sevinç Gücüm, Lars Beedgen, Erdmann Rapp, Valerian Grote, Marcus Hoffmann, Thomas Thumberger, Roman Sakson
Patients suffering from Congenital Disorders of Glycosylation (CDG) carry mutations in components of the evolutionarily highly conserved protein-glycosylation-machinery. Employing targeted genome editing, we modeled alleles in medaka fish based on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91aade339aee5430346d01099f888112
https://doi.org/10.1101/2020.08.20.260430
https://doi.org/10.1101/2020.08.20.260430
Autor:
Erdmann Rapp, Valerian Grote, Matthias Franzreb, Samanta Cajic, Udo Reichl, Thomas Fischöder, Lothar Elling, Raphael Heinzler
Publikováno v:
Molecules, Vol 24, Iss 19, p 3482 (2019)
Molecules : a journal of synthetic chemistry and natural product chemistry 24(19), 3482 (2019). doi:10.3390/molecules24193482
Molecules, 24 (19), 3482
Molecules
Volume 24
Issue 19
Molecules : a journal of synthetic chemistry and natural product chemistry 24(19), 3482 (2019). doi:10.3390/molecules24193482
Molecules, 24 (19), 3482
Molecules
Volume 24
Issue 19
Several health benefits, associated with human milk oligosaccharides (HMOS), have been revealed in the last decades. Further progress, however, requires not only the establishment of a simple "routine" method for absolute quantification of complex HM