Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Valerian B. Pinto"'
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79304 (2013)
A native outer membrane vesicles (NOMV) vaccine was developed from three antigenically diverse strains of Neisseria meningitidis that express the L1,8, L2, and L3,7 lipooligosaccharide (LOS) immunotypes, and whose synX, and lpxL1 genes were deleted..
Externí odkaz:
https://doaj.org/article/99c519e0e54d458d87863cff739aa3d9
Autor:
Craig T. Przysiecki, Xin-Ming Wang, Valerian B. Pinto, Wendell D. Zollinger, Elizabeth E. Moran, Arthur Fridman, Francisco Cruz, Robert Burden
Publikováno v:
Vaccine. 29:7752-7758
A trivalent native outer membrane vesicle vaccine that has potential to provide broad based protection against Neisseria meningitidis serogroup B strains has been developed. Preliminary immunogenicity studies in mice showed that the vaccine was capab
Autor:
S. Biggs-Cicatelli, Robert Burden, James E. Moon, James F. Cummings, E. E. Moran, Wendell D. Zollinger, Paul B. Keiser, Deborah H. Schmiel, Lori Miller, Valerian B. Pinto, Robert A. Bowden
Publikováno v:
Vaccine. 29:1413-1420
This phase I clinical trial assessed the safety and immunogenicity of a native outer membrane vesicle (NOMV) vaccine prepared from an lpxL1(-) synX(-) mutant of strain 8570(B:4:P1.19,15:L8-5) of Neisseria meningitidis. Additional mutations enhance th
Autor:
Valerian B. Pinto, Paul B. Keiser, Mark B. Stoddard, Ping Chen, Wendell D. Zollinger, Joseph E. Labrie, Deborah H. Schmiel, E. E. Moran, Trinka S. Coster, Barnett Gibbs
Publikováno v:
Vaccine. 28:6970-6976
This phase 1 clinical trial assessed the safety and immunogenicity of a native outer membrane vesicle (NOMV) vaccine prepared from a lpxL2(-) synX(-) mutant of strain 44/76 with opcA expression stabilized. Thirty-four volunteers were assigned to one
Autor:
Elizabeth E. Moran, Mikhail A. Donets, Paul B. Keiser, Ryan Marques, Valerian B. Pinto, Ping Chen, Deborah H. Schmiel, Boris Ionin, Brenda L. Brandt, Wendell D. Zollinger, Max T Wu, Mark B. Stoddard, Joseph E. Labrie
Publikováno v:
Vaccine. 28:5057-5067
A vaccine based on native outer membrane vesicles (NOMV) that has potential to provide safe, broad based protection against group B strains of Neisseria meningitidis has been developed. Three antigenically diverse group B strains of N. meningitidis w
Publikováno v:
Clinical and Vaccine Immunology. 17:98-107
Bacterial endotoxin interacts with the human immune system via complex immunological pathways. The evaluation of endotoxicity is important in the development of safe vaccines and immunomodulatory therapeutics. The Limulus amebocyte lysate (LAL) assay
Publikováno v:
Journal of Virology. 74:10202-10206
If foreign genes are ubiquitously expressed in mice using a viral vector, expression is abrogated by CD8+cells in 2 to 4 weeks. However, if the expression of the genes is confined to skeletal muscle cells, the CD8+T-cell response is much weaker and e
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79304 (2013)
PLoS ONE
PLoS ONE
A native outer membrane vesicles (NOMV) vaccine was developed from three antigenically diverse strains of Neisseria meningitidis that express the L1,8, L2, and L3,7 lipooligosaccharide (LOS) immunotypes, and whose synX, and lpxL1 genes were deleted..
Autor:
Valerian B. Pinto, Kenneth L. Rock
Publikováno v:
Cellular Immunology. 155:144-155
PBK101 was a thymic T cell line of AKR/J origin that expressed Thy 1, CD44, IL-2R, and VLA-4 antigens but not CD4, CD8, or the TCR/CD3 complex. PBK101 was initially isolated growing together with adherent thymic stromal cells. The proliferation of PB
Publikováno v:
Journal of Immunological Methods. 126:147-157
Specific interactions between multiple cell types are critical for a variety of processes central to the development, homeostasis and immune defense of multicellular organisms. Studies designed to elucidate how cells communicate through physical enco