Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Valeria R Fantin"'
Autor:
Shu-Hui Liu, Yin Gu, Bernadette Pascual, Zhengming Yan, Max Hallin, Cathy Zhang, Conglin Fan, Wenlian Wang, Justine Lam, Mary E. Spilker, Rolla Yafawi, Eileen Blasi, Brett Simmons, Nanni Huser, Wei-Hsien Ho, Kevin Lindquist, Thomas-Toan Tran, Jyothirmayee Kudaravalli, Jing-Tyan Ma, Gretchen Jimenez, Ishita Barman, Colleen Brown, Sherman Michael Chin, Maria J. Costa, David Shelton, Tod Smeal, Valeria R. Fantin, Flavia Pernasetti
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 1088-1100 (2017)
Abstract: The chemokine receptor CXCR4 is highly expressed and associated with poor prognosis in multiple malignancies. Upon engagement by its ligand, CXCL12, CXCR4 triggers intracellular signaling pathways that control trafficking of cells to tissue
Externí odkaz:
https://doaj.org/article/6df94e3160ac4a0297441615788d740b
Autor:
Manoj K. Kashyap, Carlos I. Amaya-Chanaga, Deepak Kumar, Brett Simmons, Nanni Huser, Yin Gu, Max Hallin, Kevin Lindquist, Rolla Yafawi, Michael Y. Choi, Ale-Ali Amine, Laura Z. Rassenti, Cathy Zhang, Shu-Hui Liu, Tod Smeal, Valeria R. Fantin, Thomas J. Kipps, Flavia Pernasetti, Januario E. Castro
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-16 (2017)
Abstract Background The CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported in different hematological malignancies including CLL. Binding of the
Externí odkaz:
https://doaj.org/article/c1cbefb66ea643659235e75122642524
Autor:
Manfred Kraus, Joseph Tumang, Xianxian Zheng, Li-Chin Yao, Martin Wythes, Benoit J. Van den Eynde, Konstantinos Tsaparikos, Vince R. Torti, Nicole Streiner, Chad Ray, Virginie Rabolli, Romain Pirson, Nichol Miller, Reece Marillier, Karen Maegley, Wenlin Li, Marie-Claire Letellier, Jie Guo, Valeria R. Fantin, Christopher P. Dillon, Sofie Denies, Deepak Dalvie, Stefano Crosignani, Sandra Cauwenberghs, Danying Cai, Derek Bartlett, Gregory Driessens, Bruno Gomes
Table S2 shows a selectivity screen of PF-06840003 in in vitro pharmacological assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47698983ea67ec47db744f5010daf12a
https://doi.org/10.1158/1535-7163.22505134
https://doi.org/10.1158/1535-7163.22505134
Autor:
Manfred Kraus, Joseph Tumang, Xianxian Zheng, Li-Chin Yao, Martin Wythes, Benoit J. Van den Eynde, Konstantinos Tsaparikos, Vince R. Torti, Nicole Streiner, Chad Ray, Virginie Rabolli, Romain Pirson, Nichol Miller, Reece Marillier, Karen Maegley, Wenlin Li, Marie-Claire Letellier, Jie Guo, Valeria R. Fantin, Christopher P. Dillon, Sofie Denies, Deepak Dalvie, Stefano Crosignani, Sandra Cauwenberghs, Danying Cai, Derek Bartlett, Gregory Driessens, Bruno Gomes
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f74526ae85eebdbe19c754931a606d3
https://doi.org/10.1158/1535-7163.22505140
https://doi.org/10.1158/1535-7163.22505140
Autor:
Manfred Kraus, Joseph Tumang, Xianxian Zheng, Li-Chin Yao, Martin Wythes, Benoit J. Van den Eynde, Konstantinos Tsaparikos, Vince R. Torti, Nicole Streiner, Chad Ray, Virginie Rabolli, Romain Pirson, Nichol Miller, Reece Marillier, Karen Maegley, Wenlin Li, Marie-Claire Letellier, Jie Guo, Valeria R. Fantin, Christopher P. Dillon, Sofie Denies, Deepak Dalvie, Stefano Crosignani, Sandra Cauwenberghs, Danying Cai, Derek Bartlett, Gregory Driessens, Bruno Gomes
Table S1 shows the plasma protein binding and blood to plasma ratio in mouse, rat, dog and human. Table S3 shows the plasma concentrations following a single oral dose of PF-06840003. Figure S1 shows that PF-06840003 does not impact cell viability. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a821fe08534fa5982eef4c3eb5ce76
https://doi.org/10.1158/1535-7163.22505137
https://doi.org/10.1158/1535-7163.22505137
Autor:
Manfred Kraus, Joseph Tumang, Xianxian Zheng, Li-Chin Yao, Martin Wythes, Benoit J. Van den Eynde, Konstantinos Tsaparikos, Vince R. Torti, Nicole Streiner, Chad Ray, Virginie Rabolli, Romain Pirson, Nichol Miller, Reece Marillier, Karen Maegley, Wenlin Li, Marie-Claire Letellier, Jie Guo, Valeria R. Fantin, Christopher P. Dillon, Sofie Denies, Deepak Dalvie, Stefano Crosignani, Sandra Cauwenberghs, Danying Cai, Derek Bartlett, Gregory Driessens, Bruno Gomes
Tumors use indoleamine 2,3-dioxygenase-1 (IDO1) as a major mechanism to induce an immunosuppressive microenvironment. IDO1 expression is upregulated in many cancers and considered to be a resistance mechanism to immune checkpoint therapies. IDO1 is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b26f8def31d8e1dfcb01fcbd392ab72
https://doi.org/10.1158/1535-7163.c.6537964.v1
https://doi.org/10.1158/1535-7163.c.6537964.v1
Autor:
Victoria M. Richon, Stanley R. Frankel, Marshall E. Kadin, Christopher M. Ware, John F. Reilly, Sophia Randolph, Elizabeth A. Harrington, Xiaoli S. Hou, Susan Korenchuk, Frank Gooden, Lixia Li, Jennifer A. Roth, Jacqueline W. Pierce, Ronald C. Hendrickson, Cloud P. Paweletz, Andrey Loboda, Valeria R. Fantin
Supplementary Figure 8 from Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034f4932a1dfc60023fb00c753b876b9
https://doi.org/10.1158/0008-5472.22370531.v1
https://doi.org/10.1158/0008-5472.22370531.v1
Autor:
Victoria M. Richon, Stanley R. Frankel, Marshall E. Kadin, Christopher M. Ware, John F. Reilly, Sophia Randolph, Elizabeth A. Harrington, Xiaoli S. Hou, Susan Korenchuk, Frank Gooden, Lixia Li, Jennifer A. Roth, Jacqueline W. Pierce, Ronald C. Hendrickson, Cloud P. Paweletz, Andrey Loboda, Valeria R. Fantin
Vorinostat is a histone deacetylase inhibitor that induces differentiation, growth arrest, and/or apoptosis of malignant cells both in vitro and in vivo and has shown clinical responses in ∼30% of patients with advanced mycosis fungoides and Séza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0534d95e348157177b3d5bc8200e1ef1
https://doi.org/10.1158/0008-5472.c.6496430
https://doi.org/10.1158/0008-5472.c.6496430
Autor:
Victoria M. Richon, Stanley R. Frankel, Marshall E. Kadin, Christopher M. Ware, John F. Reilly, Sophia Randolph, Elizabeth A. Harrington, Xiaoli S. Hou, Susan Korenchuk, Frank Gooden, Lixia Li, Jennifer A. Roth, Jacqueline W. Pierce, Ronald C. Hendrickson, Cloud P. Paweletz, Andrey Loboda, Valeria R. Fantin
Supplementary Figure 1 from Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad2e5f25d74a2578365f71b01083778
https://doi.org/10.1158/0008-5472.22370555.v1
https://doi.org/10.1158/0008-5472.22370555.v1
Autor:
Victoria M. Richon, Stanley R. Frankel, Marshall E. Kadin, Christopher M. Ware, John F. Reilly, Sophia Randolph, Elizabeth A. Harrington, Xiaoli S. Hou, Susan Korenchuk, Frank Gooden, Lixia Li, Jennifer A. Roth, Jacqueline W. Pierce, Ronald C. Hendrickson, Cloud P. Paweletz, Andrey Loboda, Valeria R. Fantin
Supplementary Figure 7 from Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048b49aadf6d307fb6408e3a831ce2be
https://doi.org/10.1158/0008-5472.22370534
https://doi.org/10.1158/0008-5472.22370534