Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Valeria Quaranta"'
Autor:
Meirion Raymant, Yuliana Astuti, Laura Alvaro-Espinosa, Daniel Green, Valeria Quaranta, Gaia Bellomo, Mark Glenn, Vatshala Chandran-Gorner, Daniel H. Palmer, Christopher Halloran, Paula Ghaneh, Neil C. Henderson, Jennifer P. Morton, Manuel Valiente, Ainhoa Mielgo, Michael C. Schmid
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease for which better therapies are urgently needed. Fibroblasts and macrophages are heterogeneous cell populations able to enhance metastasis, but the role of a macrophage-fi
Externí odkaz:
https://doaj.org/article/eea8d7fa84a347b4b29c4bbb66667b6a
Publikováno v:
Cancers, Vol 16, Iss 9, p 1772 (2024)
Liver cancer is one of the leading causes of cancer-related mortality. Hepatocellular carcinoma and cholangiocarcinoma are the most common types, and despite numerous advances, therapeutic options still remain poor for these cancer patients. Tumor de
Externí odkaz:
https://doaj.org/article/48361ef2aa8e4631a16cd9d9b8d5e5fc
Publikováno v:
Cancers, Vol 15, Iss 22, p 5359 (2023)
Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide. Metastasis is the prime driver of CRC-related mortality, and the liver is the organ most frequently involved. Despite the overall success of current treatments, col
Externí odkaz:
https://doaj.org/article/7e26d37ae78540c8a3db0fbd3c9f9f99
Autor:
Matteo Filippini, Mauro Serpelloni, Valeria Quaranta, Paolo Bellitti, Emilio Sardini, Nicola Latronico
Publikováno v:
Pulmonary Medicine, Vol 2019 (2019)
Aim. To evaluate the conditioning capabilities of the DAR™ Hygrobac™ S, a Heat and Moisture Exchanger (HME), using a new device to measure the temperature (T) and the absolute humidity (AH) of the ventilated gases in vivo during mechanical ventil
Externí odkaz:
https://doaj.org/article/d1994fe2137d48b9b2a191bff95b5757
Autor:
Valeria Quaranta, Michael C. Schmid
Publikováno v:
Cells, Vol 8, Iss 7, p 747 (2019)
Despite the incredible clinical benefits obtained by the use of immune checkpoint blockers (ICBs), resistance is still common for many types of cancer. Central for ICBs to work is activation and infiltration of cytotoxic CD8+ T cells following tumour
Externí odkaz:
https://doaj.org/article/1fc9ebad9c9e46048e1a302a99e3d2e6
Autor:
Michael C. Schmid, Ainhoa Mielgo, David A. Tuveson, Daniel H. Palmer, Fiona Campbell, Trish Murray, Arthur Taylor, Dannielle D. Engle, Muhammad S. Ahmed, Meirion L. Raymant, Sebastian R. Nielsen, Carolyn Rainer, Valeria Quaranta
The ability of disseminated cancer cells to evade the immune response is a critical step for efficient metastatic progression. Protection against an immune attack is often provided by the tumor microenvironment that suppresses and excludes cytotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c50fc90d028394b7e23b08fae8143f
https://doi.org/10.1158/0008-5472.c.6510191.v1
https://doi.org/10.1158/0008-5472.c.6510191.v1
Autor:
Ainhoa Mielgo, Michael C. Schmid, Fiona Campbell, David A. Tuveson, Thomas Bogenrieder, Azzam Taktak, Sarah E. Coupland, Pedro A. Perez-Mancera, Danielle D. Engle, Ulrike Weyer-Czernilofsky, Valeria Quaranta, Sebastian R. Nielsen, Carolyn Rainer, Muhammad S. Ahmed, Almudena Santos, Lucy Ireland
Fig. S1. Primary M2-like macrophages express IGF-1 and IGF-2. Fig. S2. In the absence of chemotherapy, addition of MCM, IGF blockade or recombinant IGF does not affect proliferation or survival of pancreatic cancer cells. Fig.S3. MCM enhances resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06902771ee91c13e027d15cd82063e3a
https://doi.org/10.1158/0008-5472.22412769.v1
https://doi.org/10.1158/0008-5472.22412769.v1
Autor:
Ainhoa Mielgo, Michael C. Schmid, Fiona Campbell, David A. Tuveson, Thomas Bogenrieder, Azzam Taktak, Sarah E. Coupland, Pedro A. Perez-Mancera, Danielle D. Engle, Ulrike Weyer-Czernilofsky, Valeria Quaranta, Sebastian R. Nielsen, Carolyn Rainer, Muhammad S. Ahmed, Almudena Santos, Lucy Ireland
Supplementary Figure legends. Table S1. Clinical information from 40 consented PDA patient samples. Table S2. Clinical information from 16 consented PDA patient samples. Supplementary Materials and Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05193f27a952663e6bd42aea594e452f
https://doi.org/10.1158/0008-5472.22412772.v1
https://doi.org/10.1158/0008-5472.22412772.v1
Autor:
Michael C. Schmid, Ainhoa Mielgo, David A. Tuveson, Daniel H. Palmer, Fiona Campbell, Trish Murray, Arthur Taylor, Dannielle D. Engle, Muhammad S. Ahmed, Meirion L. Raymant, Sebastian R. Nielsen, Carolyn Rainer, Valeria Quaranta
Files in this Data Supplement: - Supplementary Figures. Figure S1: Loss of CD8+ T cell numbers during metastatic progression in PDAC patients and genetically engineered mouse model of pancreatic cancer. Figure S2: Colony stimulating factor 1 (CSF-1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4529d16f73d999f81abb92634ac227
https://doi.org/10.1158/0008-5472.22418660.v1
https://doi.org/10.1158/0008-5472.22418660.v1
Autor:
Ainhoa Mielgo, Michael C. Schmid, Fiona Campbell, David A. Tuveson, Thomas Bogenrieder, Azzam Taktak, Sarah E. Coupland, Pedro A. Perez-Mancera, Danielle D. Engle, Ulrike Weyer-Czernilofsky, Valeria Quaranta, Sebastian R. Nielsen, Carolyn Rainer, Muhammad S. Ahmed, Almudena Santos, Lucy Ireland
Tumor-associated macrophages (TAM) and myofibroblasts are key drivers in cancer that are associated with drug resistance in many cancers, including pancreatic ductal adenocarcinoma (PDAC). However, our understanding of the molecular mechanisms by whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::767b3c11e3a8231146a3b420547451b4
https://doi.org/10.1158/0008-5472.c.6508512.v1
https://doi.org/10.1158/0008-5472.c.6508512.v1