Výsledky vyhledávání - "Valeria Puntorieri"

Apolipoprotein E-Deficient Mice Are Susceptible to the Development of Acute Lung Injury

Autor: Valeria Puntorieri, Lynda McCaig, Joanne Lac, Li-Juan Yao, Cory Yamashita, Jennifer H. Madenspacher, Sanjay Mehta, James F. Lewis, Ruud A. W. Veldhuizen, Lefeng Wang, Lakshman Vasanthamohan, Michael B. Fessler

Publikováno v: Respiration. 87:416-427

Background: Apolipoprotein E (apoE) has been shown to play a pivotal role in the development of cardiovascular disease, attributable to its function in lipid trafficking and immune modulating properties; however, its role in modulating inflammation i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc6836da62f9ed2ce9e0813fee53ce2
https://doi.org/10.1159/000358438

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Lack of matrix metalloproteinase 3 in mouse models of lung injury ameliorates the pulmonary inflammatory response in female but not in male mice

Autor: Lynda McCaig, Valeria Puntorieri, Li-Juan Yao, James F. Lewis, Christopher J. Howlett, Cory Yamashita, Ruud A. W. Veldhuizen

Publikováno v: Experimental lung research. 42(7)

Background: The acute respiratory distress syndrome (ARDS) is a complex pulmonary disorder in which the local release of cytokines and chemokines appears central to the pathophysiology. Objective: Based on the known role of matrix metalloproteinase-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b0d986ceea697b3db2895fb5747352
https://pubmed.ncbi.nlm.nih.gov/27676418

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The effects of exogenous surfactant administration on ventilation-induced inflammation in mouse models of lung injury

Autor: James F. Lewis, Li-Juan Yao, Ruud A. W. Veldhuizen, Valeria Puntorieri, Lynda McCaig, Josh Qua Hiansen

Publikováno v: BMC Pulmonary Medicine

Background Mechanical ventilation (MV) is an essential supportive therapy for acute lung injury (ALI); however it can also contribute to systemic inflammation. Since pulmonary surfactant has anti-inflammatory properties, the aim of the study was to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff5a8ad690f88359d466539e5b23f59
https://pubmed.ncbi.nlm.nih.gov/24256698

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Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema

Autor: Andrea Ferrari, Barbara Assenzio, Stefano Italiano, Vito Fanelli, Lorenzo Del Sorbo, Vincenzo Elia, Arthur S. Slutsky, Emilio Hirsch, E. L. Martin, Martino Bosco, Luisa Delsedime, V. Marco Ranieri, Valeria Puntorieri, Alessandra Ghigo

BACKGROUND: Ventilator-induced lung injury (VILI) occurs in part by increased vascular permeability and impaired alveolar fluid clearance. Phosphoinositide 3-kinase gamma (PI3Kγ) is activated by mechanical stress, induces nitric oxide (NO) productio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3f7f13348adacbf3939f006da8cf1c
http://hdl.handle.net/11585/663555

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Pulmonary atelectasis during low stretch ventilation: 'open lung' versus 'lung rest' strategy

Autor: Luciana Mascia, Barbara Assenzio, Valeria Puntorieri, Luisa Delsedime, V. Marco Ranieri, Giancarlo Fornaro, Salvatore Grasso, Martino Bosco, Vito Fanelli, Tommaso Fiore, Vincenzo Elia, E. L. Martin

Publikováno v: Critical care medicine. 37(3)

OBJECTIVE: Limiting tidal volume (VT) may minimize ventilator-induced lung injury (VILI). However, atelectasis induced by low VT ventilation may cause ultrastructural evidence of cell disruption. Apoptosis seems to be involved as protective mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919553c8e1be935f6205bc431afbfb69
https://pubmed.ncbi.nlm.nih.gov/19237950

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Polymyxin-B hemoperfusion inactivates circulating proapoptotic factors

Autor: Giuseppe Paolo Segoloni, Valeria Puntorieri, Alfonso Pacitti, V. Marco Ranieri, Barbara Assenzio, Luciana Mascia, Daniela Pasero, Gianpaola Monti, Giovanni Camussi, Giuseppe Mauriello Romanazzi, Giacomo Lanfranco, Giampaolo Casella, Vincenzo Cantaluppi, E. L. Martin

Publikováno v: Intensive Care Medicine

Objective To test the hypothesis that extracorporeal therapy with polymyxin B (PMX-B) may prevent Gram-negative sepsis-induced acute renal failure (ARF) by reducing the activity of proapoptotic circulating factors. Setting Medical-Surgical Intensive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703a120cf3de95d271538966ad66aeb5
http://hdl.handle.net/2318/82680

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Expression of Pax2 in Human Renal Tumor-Derived Endothelial Cells Sustains Apoptosis Resistance and Angiogenesis

Autor: Maria Chiara Deregibus, Valeria Puntorieri, Stefano Buttiglieri, Giovanni Camussi, Benedetta Bussolati, Valentina Fonsato

The transcription factor Pax2 is known to play a key role during renal development and to act as an oncogene favoring renal tumor growth. We recently showed that endothelial cells derived from human renal carcinomas display abnormal characteristics o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0690bc0d59c56e430d55eb3bd747fa
https://europepmc.org/articles/PMC1606486/

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