Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Valeria Padovano"'
Autor:
Laura Onuchic, Valeria Padovano, Giorgia Schena, Vanathy Rajendran, Ke Dong, Xiaojian Shi, Raj Pandya, Victoria Rai, Nikolay P. Gresko, Omair Ahmed, TuKiet T. Lam, Weiwei Wang, Hongying Shen, Stefan Somlo, Michael J. Caplan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Mutations in the gene encoding PC1 cause ADPKD, a common genetic renal disease. Here, the authors show that expression of the C-terminal 200 amino acids of the large PC1 protein in mouse models of ADPKD suppresses cystic disease through an interactio
Externí odkaz:
https://doaj.org/article/5169c69bfd7145fcafbf112cbbe1e4dd
Autor:
Mu He, Bing Wu, Wenlei Ye, Daniel D Le, Adriane W Sinclair, Valeria Padovano, Yuzhang Chen, Ke-Xin Li, Rene Sit, Michelle Tan, Michael J Caplan, Norma Neff, Yuh Nung Jan, Spyros Darmanis, Lily Yeh Jan
Publikováno v:
eLife, Vol 9 (2020)
The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction
Externí odkaz:
https://doaj.org/article/3a06ea545a1440859b05a65eab370713
Autor:
Laura Onuchic, Valeria Padovano, Giorgia Schena, Xiaojian Shi, Ke Dong, Vanathy Rajendran, Victoria Rai, Raj Pandya, Nikolay Gresko, Hongying Shen, Stefan Somlo, Michael Caplan
Publikováno v:
Physiology. 38
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common life-threatening genetic diseases. Mutations in the PKD1 gene, which encodes polycystin-1, account for ~78% of cases. We have previously shown that transgenic
Autor:
Laura Onuchic, Valeria Padovano, Giorgia Schena, Vanathy Rajendran, Ke Dong, Nikolay P. Gresko, Xiaojian Shi, Hongying Shen, Stefan Somlo, Michael J. Caplan
SUMMARYAutosomal dominant polycystic kidney disease (ADPKD) is the most prevalent potentially lethal monogenic disorder. Approximately 78% of cases are caused by mutations in the PKD1 gene, which encodes polycystin-1 (PC1). PC1 is a large 462-kDa pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d3ecbd033dfd6a45c455fc8b0d47ae
https://doi.org/10.1101/2021.12.21.473680
https://doi.org/10.1101/2021.12.21.473680
Autor:
Keith Keller, Michelle Melanson, Choah Kim, Jillian L. Shaw, Luciene Ronco, Jamie L. Marshall, Katherine A. Vernon, Anna Greka, Juan Lorenzo B. Pablo, Seth L. Alper, Eriene-Heidi Sidhom, Florence F. Wagner, George C. Tsokos, Elizabeth J. Grinkevich, Moran Dvela-Levitt, Matthew Racette, Valeria Padovano, Julie Roignot, Frederick W.K. Tam, Abbe Clark, Ayshwarya Subramanian, Jean Santos, Alissa Campbell, Astrid Weins, Juan Gutierrez, Abhigyan Satyam, Andrew J.B. Watts, Stephen P. McAdoo, Maheswarareddy Emani, Silvana Bazua-Valenti, Estefanía Reyes-Bricio, Maria Kost-Alimova, Juliana Coraor, Brian T. Chamberlain, Patrick J. Byrne, Rebecca Thompson
Publikováno v:
Cell Reports Medicine
bioRxiv
bioRxiv
Drug repurposing is the only method capable of delivering treatments on the shortened time-scale required for patients afflicted with lung disease arising from SARS-CoV-2 infection. Mucin-1 (MUC1), a membrane-bound molecule expressed on the apical su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac05c8ae52c2a9ddd2eedf3972ff732d
http://hdl.handle.net/10044/1/83980
http://hdl.handle.net/10044/1/83980
Autor:
Alissa Campbell, Katherine A. Vernon, Rebecca Thompson, Anna Greka, Julie Roignot, Silvana Bazua-Valenti, Eriene-Heidi Sidhom, Florence F. Wagner, Seth L. Alper, Frederick W.K. Tam, Matthew Racette, Abbe Clark, Michelle Melanson, Ayshwarya Subramanian, Jean Santos, Choah Kim, Estefania Reyes Bricio, Astrid Weins, George C. Tsokos, Jillian L. Shaw, Elizabeth J. Grinkevich, Juliana Coraor, Andrew J. R. Watts, Lucienne V. Ronco, Juan Gutierrez, Keith Keller, Moran Dvela-Levitt, Maria Alimova, Maheswarareddy Emani, Juan Pablo, Abhigyan Satyam, Valeria Padovano, Stephen P. McAdoo, Brian T. Chamberlain, Jamie L. Marshall
Publikováno v:
Cell Reports Medicine
Summary Drug repurposing has the advantage of identifying potential treatments on a shortened timescale. In response to the pandemic spread of SARS-CoV-2, we took advantage of a high-content screen of 3,713 compounds at different stages of clinical d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014b2c3625f75412ce10742b925a6461
https://doi.org/10.1101/2020.06.30.180380
https://doi.org/10.1101/2020.06.30.180380
Autor:
Norma Neff, Valeria Padovano, Daniel D. Le, Spyros Darmanis, Rene Sit, Michelle Tan, Lily Yeh Jan, Yuh Nung Jan, Adriane Sinclair, Ke-Xin Li, Michael J. Caplan, Mu He, Bing Wu, Yuzhang Chen, Wenlei Ye
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57eaf35d47b3e0cf11a560a681b85400
https://escholarship.org/uc/item/5ct5h452
https://escholarship.org/uc/item/5ct5h452
Autor:
Michelle Tan, Daniel D. Le, Mu He, Lily Yeh Jan, Valeria Padovano, Norma Neff, Yuh Nung Jan, Bing Wu, Wenlei Ye, Yuzhang Chen, Ke-Xin Li, Michael J. Caplan, Adriane Sinclair, Spyros Darmanis, Rene Sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::220d36de29cc65959876ae4d8bfd661e
https://doi.org/10.7554/elife.53085.sa2
https://doi.org/10.7554/elife.53085.sa2
Publikováno v:
Cell Signal
The polycystin-1 and 2 proteins, encoded by the genes mutated in Autosomal Dominant Polycystic Kidney Disease, are connected to a large number of biological pathways. While the nature of these connections and their relevance to the primary functions
Publikováno v:
Nature Reviews Nephrology. 14:678-687
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common, potentially lethal, monogenic diseases and is caused predominantly by mutations in polycystic kidney disease 1 (PKD1) and PKD2, which encode polycystin 1 (PC1) and PC2, r