Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Valeria Lulla"'
Autor:
Charlotte Lefèvre, Georgia M. Cook, Adam M. Dinan, Shiho Torii, Hazel Stewart, George Gibbons, Alex S. Nicholson, Liliana Echavarría-Consuegra, Luke W. Meredith, Valeria Lulla, Naomi McGovern, Julia C. Kenyon, Ian Goodfellow, Janet E. Deane, Stephen C. Graham, András Lakatos, Louis Lambrechts, Ian Brierley, Nerea Irigoyen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Zika virus (ZIKV), an emerging mosquito-borne flavivirus, is associated with congenital neurological complications. Here, we investigate potential pathological correlates of virus gene expression in representative ZIKV strains through RNA se
Externí odkaz:
https://doaj.org/article/2dc4a2034fc449a8bca35da7cbd3b0c0
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1011959 (2024)
An essential aspect of positive-sense RNA virus replication is anchoring the replication complex (RC) to cellular membranes. Positive-sense RNA viruses employ diverse strategies, including co-translational membrane targeting through signal peptides a
Externí odkaz:
https://doaj.org/article/fc643a5c6fae49129dc53e40a8bdd5fc
Autor:
Hazel Stewart, Yongxu Lu, Sarah O’Keefe, Anusha Valpadashi, Luis Daniel Cruz-Zaragoza, Hendrik A. Michel, Samantha K. Nguyen, George W. Carnell, Nina Lukhovitskaya, Rachel Milligan, Yasmin Adewusi, Irwin Jungreis, Valeria Lulla, David A. Matthews, Stephen High, Peter Rehling, Edward Emmott, Jonathan L. Heeney, Andrew D. Davidson, James R. Edgar, Geoffrey L. Smith, Andrew E. Firth
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108080- (2023)
Summary: The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative genomic approaches, an additional accessory protein, ORF3c, has been predicted to be encoded within the ORF3a sgmRNA. Expression of ORF3c during infection has
Externí odkaz:
https://doaj.org/article/0eb2381740c24412b7c9b4e912187e2a
Autor:
Hashim Ali, Aleksei Lulla, Alex S Nicholson, Jacqueline Hankinson, Elizabeth B Wignall-Fleming, Rhian L O'Connor, Diem-Lan Vu, Stephen C Graham, Janet E Deane, Susana Guix, Valeria Lulla
Publikováno v:
PLoS Biology, Vol 21, Iss 7, p e3001815 (2023)
During the last decade, the detection of neurotropic astroviruses has increased dramatically. The MLB genogroup of astroviruses represents a genetically distinct group of zoonotic astroviruses associated with gastroenteritis and severe neurological c
Externí odkaz:
https://doaj.org/article/e8a8b4e39a874fd7b4e555bd3fe2873d
Autor:
Valeria Lulla, Andrew E. Firth
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Astroviruses are common human pathogens and their genomes contain three known protein-coding genes. Here, Lulla et al. report a fourth, previously overlooked gene encoding protein XP which has a viroporin-like activity that is important for efficient
Externí odkaz:
https://doaj.org/article/b52d01832d8e493da92213e3f81e0b32
Autor:
Valeria Lulla, Andrew Firth
Publikováno v:
Bio-Protocol, Vol 9, Iss 10 (2019)
In virology the difference between the fitness of two viruses can be determined by using various methods, such as virus titer, growth curve analysis, measurement of virus infectivity, analysis of produced RNA copies and viral protein production. Howe
Externí odkaz:
https://doaj.org/article/f7caef5a11ca4e608fd68b052a64ee91
Autor:
Zhisheng Her, Terk‐Shin Teng, Jeslin JL Tan, Teck‐Hui Teo, Yiu‐Wing Kam, Fok‐Moon Lum, Wendy WL Lee, Christelle Gabriel, Rossella Melchiotti, Anand K Andiappan, Valeria Lulla, Aleksei Lulla, Mar K Win, Angela Chow, Subhra K Biswas, Yee‐Sin Leo, Marc Lecuit, Andres Merits, Laurent Rénia, Lisa FP Ng
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 1, Pp 24-41 (2014)
Abstract RNA‐sensing toll‐like receptors (TLRs) mediate innate immunity and regulate anti‐viral response. We show here that TLR3 regulates host immunity and the loss of TLR3 aggravates pathology in Chikungunya virus (CHIKV) infection. Susceptib
Externí odkaz:
https://doaj.org/article/e45260fcb0074c7eb1f2abb56056ddc8
Autor:
Margit Mutso, Ainhoa Moliner Morro, Cecilia Smedberg, Sergo Kasvandik, Muriel Aquilimeba, Mona Teppor, Liisi Tarve, Aleksei Lulla, Valeria Lulla, Sirle Saul, Bastian Thaa, Gerald M McInerney, Andres Merits, Margus Varjak
Publikováno v:
Viruses, Vol 10, Iss 5, p 226 (2018)
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus
Externí odkaz:
https://doaj.org/article/436e6e42498f4d28a75d5d8db1b0d5fb
Publikováno v:
Bio-Protocol, Vol 4, Iss 10 (2014)
Type I interferons (IFN-α/β) play an important role in host resistance to viral infections. Signaling through the JAK-STAT pathway, IFN-α/β stimulates response elements (ISRE) in the promoters of ISG to regulate their expression (reviewed in Refe
Externí odkaz:
https://doaj.org/article/5fbaaee0546747fd8febb6d0c8c08acd
Autor:
Andrei Nikonov, Tarmo Mölder, Rein Sikut, Kaja Kiiver, Andres Männik, Urve Toots, Aleksei Lulla, Valeria Lulla, Age Utt, Andres Merits, Mart Ustav
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003610 (2013)
Type I interferons (IFN) are important for antiviral responses. Melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-induced gene I (RIG-I) proteins detect cytosolic double-stranded RNA (dsRNA) or 5'-triphosphate (5'-ppp) RNA and medi
Externí odkaz:
https://doaj.org/article/fff43a4dc9a84a7693e5b9572e5f3f4e