Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Valeria Losasso"'
Autor:
Sarah R. Needham, Selene K. Roberts, Anton Arkhipov, Venkatesh P. Mysore, Christopher J. Tynan, Laura C. Zanetti-Domingues, Eric T. Kim, Valeria Losasso, Dimitrios Korovesis, Michael Hirsch, Daniel J. Rolfe, David T. Clarke, Martyn D. Winn, Alireza Lajevardipour, Andrew H. A. Clayton, Linda J. Pike, Michela Perani, Peter J. Parker, Yibing Shan, David E. Shaw, Marisa L. Martin-Fernandez
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Epidermal growth factor receptors have been shown to oligomerise upon binding to their cognate ligands. Here, the authors use biochemical, biophysical and cell biology techniques to analyse the structures of these oligomers, and argue that these form
Externí odkaz:
https://doaj.org/article/4106f1db16d64a39ab5d782e227f6e6e
Autor:
Anna Bochicchio, Sandra Jordaan, Valeria Losasso, Shivan Chetty, Rodrigo Casasnovas Perera, Emiliano Ippoliti, Stefan Barth, Paolo Carloni
Publikováno v:
Biomedicines, Vol 5, Iss 1, p 9 (2017)
Targeted human cytolytic fusion proteins (hCFPs) are humanized immunotoxins for selective treatment of different diseases including cancer. They are composed of a ligand specifically binding to target cells genetically linked to a human apoptosis-ind
Externí odkaz:
https://doaj.org/article/84a6e6881deb49c7ace63c399f423782
Autor:
Diane Latawiec, Fernando Herrera, Alpan Bek, Valeria Losasso, Michela Candotti, Federico Benetti, Elvio Carlino, Agata Kranjc, Marco Lazzarino, Stefano Gustincich, Paolo Carloni, Giuseppe Legname
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9234 (2010)
The action of dopamine on the aggregation of the unstructured alpha-synuclein (alpha-syn) protein may be linked to the pathogenesis of Parkinson's disease. Dopamine and its oxidation derivatives may inhibit alpha-syn aggregation by non-covalent bindi
Externí odkaz:
https://doaj.org/article/90670facb6554f35807499b7458934ba
Autor:
Valeria Losasso, Khushbu Agarwal, Morris Waskar, Amitabha Majumdar, Jason Crain, Martyn Winn, Michael Hoptroff
Publikováno v:
Biophysical Journal. 121:491-501
The skin-associated microbiome plays an important role in general well-being and in a variety of treatable skin conditions. In this regard, endogenous antimicrobial peptides have both a direct and indirect role in determining the composition of the m
Autor:
Katharine Hammond, Flaviu Cipcigan, Bart W. Hoogenboom, Marcus Fletcher, Helen Lewis, Phillip J. Stansfeld, Patrick W. Simcock, Jason Crain, Ulrich F. Keyser, Fausto Martelli, Mark S.P. Sansom, Jehangir Cama, Kareem Al Nahas, Jascindra Ravi, Valeria Losasso, Stefano Pagliara, Maxim G. Ryadnov
Publikováno v:
ACS Nano
ACS nano
ACS nano
Disruption of cell membranes is a fundamental host defense response found in virtually all forms of life. The molecular mechanisms vary but generally lead to energetically favored circular nanopores. Here, we report an elaborate fractal rupture patte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a5bebdd5de53e144ca8a16971aa6a0
http://wrap.warwick.ac.uk/154253/1/WRAP-Switching-cytolytic-nanopores-antimicrobial-fractal-ruptures-single-side-chain-mutation-2021.pdf
http://wrap.warwick.ac.uk/154253/1/WRAP-Switching-cytolytic-nanopores-antimicrobial-fractal-ruptures-single-side-chain-mutation-2021.pdf
Autor:
Jason Crain, Valeria Losasso, Martyn Winn, Hasan Alkassem, Peter J. Judge, Maxim G. Ryadnov, Nilofar Faruqui, Bart W. Hoogenboom, Marc-Philipp Pfeil, Anthony Watts, Katharine Hammond, Baptiste Lamarre, Glenn J. Martyna, Jascindra Ravi, Alice L. B. Pyne
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports
Scientific Reports
The spread of antimicrobial resistance stimulates discovery strategies that place emphasis on mechanisms circumventing the drawbacks of traditional antibiotics and on agents that hit multiple targets. Host defense peptides (HDPs) are promising candid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd108fad3886dd742387d655a71d41a
https://ora.ox.ac.uk/objects/uuid:331ba5c6-9467-4a31-94b3-e8fd1576a8e9
https://ora.ox.ac.uk/objects/uuid:331ba5c6-9467-4a31-94b3-e8fd1576a8e9
Publikováno v:
The Journal of Physical Chemistry B. 122:5908-5921
Antimicrobial peptides (AMPs) are widely occurring host defense agents of interest as one route for addressing the growing problem of multidrug-resistant pathogens. Understanding the mechanisms behind their antipathogen activity is instrumental in de
Publikováno v:
Physical Review Letters. 122
It is shown that the tendency of an archetypal antimicrobial peptide to insert into and perforate a simple lipid bilayer is strongly modulated by tensile stress in the membrane. The results, obtained through molecular dynamics simulations, have been
Autor:
Antonio Magrì, Valeria Losasso, Enrico Rizzarelli, Sebastiano Sciuto, Paolo Carloni, Adriana Pietropaolo, Valentina Greco, Diego La Mendola
Publikováno v:
ACS chemical neuroscience 9 (2018): 1095–1103. doi:10.1021/acschemneuro.7b00470
info:cnr-pdr/source/autori:Pietropaolo A.; Magri A.; Greco V.; Losasso V.; La Mendola D.; Sciuto S.; Carloni P.; Rizzarelli E./titolo:Binding of Zn(II) to Tropomyosin Receptor Kinase A in Complex with Its Cognate Nerve Growth Factor: Insights from Molecular Simulation and in Vitro Essays/doi:10.1021%2Facschemneuro.7b00470/rivista:ACS chemical neuroscience/anno:2018/pagina_da:1095/pagina_a:1103/intervallo_pagine:1095–1103/volume:9
info:cnr-pdr/source/autori:Pietropaolo A.; Magri A.; Greco V.; Losasso V.; La Mendola D.; Sciuto S.; Carloni P.; Rizzarelli E./titolo:Binding of Zn(II) to Tropomyosin Receptor Kinase A in Complex with Its Cognate Nerve Growth Factor: Insights from Molecular Simulation and in Vitro Essays/doi:10.1021%2Facschemneuro.7b00470/rivista:ACS chemical neuroscience/anno:2018/pagina_da:1095/pagina_a:1103/intervallo_pagine:1095–1103/volume:9
The binding of the human nerve growth factor (NGF) protein to tropomyosin receptor kinase A (TrkA) is associated with Alzhemeir's development. Owing to the large presence of zinc(II) ions in the synaptic compartments, the zinc ions might be bound to
Autor:
Michael Hirsch, Venkatesh Mysore, Anton Arkhipov, Eric T. Kim, Dimitrios Korovesis, Michela Perani, Valeria Losasso, Alireza Lajevardipour, Daniel J. Rolfe, Linda J. Pike, Marisa L. Martin-Fernandez, Peter J. Parker, Andrew H. A. Clayton, Laura C. Zanetti-Domingues, Christopher J. Tynan, David E. Shaw, Sarah R. Needham, Selene K. Roberts, Martyn Winn, Yibing Shan, David T. Clarke
Publikováno v:
Nature Communications
Needham, S R, Roberts, S K, Arkhipov, A, Mysore, V P, Tynan, C J, Zanetti-Domingues, L C, Kim, E T, Losasso, V, Korovesis, D, Hirsch, M, Rolfe, D J, Clarke, D T, Winn, M D, Lajevardipour, A, Clayton, A H A, Pike, L J, Perani, M, Parker, P J, Shan, Y, Shaw, D E & Martin-Fernandez, M L 2016, ' EGFR oligomerization organizes kinase-active dimers into competent signalling platforms ', Nature Communications, vol. 7, 13307 . https://doi.org/10.1038/ncomms13307
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Needham, S R, Roberts, S K, Arkhipov, A, Mysore, V P, Tynan, C J, Zanetti-Domingues, L C, Kim, E T, Losasso, V, Korovesis, D, Hirsch, M, Rolfe, D J, Clarke, D T, Winn, M D, Lajevardipour, A, Clayton, A H A, Pike, L J, Perani, M, Parker, P J, Shan, Y, Shaw, D E & Martin-Fernandez, M L 2016, ' EGFR oligomerization organizes kinase-active dimers into competent signalling platforms ', Nature Communications, vol. 7, 13307 . https://doi.org/10.1038/ncomms13307
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Epidermal growth factor receptor (EGFR) signalling is activated by ligand-induced receptor dimerization. Notably, ligand binding also induces EGFR oligomerization, but the structures and functions of the oligomers are poorly understood. Here, we use