The Combination of Molnupiravir with Nirmatrelvir or GC376 Has a Synergic Role in the Inhibition of SARS-CoV-2 Replication In Vitro

Autor: Anna Gidari, Samuele Sabbatini, Elisabetta Schiaroli, Sabrina Bastianelli, Sara Pierucci, Chiara Busti, Lucia Comez, Valeria Libera, Antonio Macchiarulo, Alessandro Paciaroni, Ilaria Vicenti, Maurizio Zazzi, Daniela Francisci

Publikováno v: Microorganisms, Vol 10, Iss 7, p 1475 (2022)

Introduction: The development of effective vaccines has partially mitigated the trend of the SARS-CoV-2 pandemic; however, the need for orally administered antiviral drugs persists. This study aims to investigate the activity of molnupiravir in combi

Externí odkaz: https://doaj.org/article/597ae296b3b14ffd81065743694ea2bf

Polymorphism of human telomeric quadruplexes with drugs: a multi-technique biophysical study

Autor: Francesco D'Amico, Claudio Masciovecchio, Alessandro Paciaroni, Heinz Amenitsch, Valeria Libera, Caterina Petrillo, C Sissi, Federico Sebastiani, Francesco Sacchetti, Lucia Comez, Barbara Rossi, Alessandro Gessini, F Bianchi, M. Longo

Publikováno v: PCCP. Physical chemistry chemical physics
22 (2020): 11583–11592. doi:10.1039/d0cp01483d
info:cnr-pdr/source/autori:Comez, L.; Bianchi, F.; Libera, V; Longo, M.; Petrillo, C.; Sacchetti, F.; Sebastiani, F.; D'Amico, F.; Rossi, B.; Gessini, A.; Masciovecchio, C.; Amenitsch, H.; Sissi, C.; Paciaroni, A./titolo:Polymorphism of human telomeric quadruplexes with drugs: a multi-technique biophysical study/doi:10.1039%2Fd0cp01483d/rivista:PCCP. Physical chemistry chemical physics (Print)/anno:2020/pagina_da:11583/pagina_a:11592/intervallo_pagine:11583–11592/volume:22

The human telomeric G-quadruplex structural motif of DNA has come to be known as a new and stimulating target for anticancer drug discovery. Small molecules that interact with G-quadruplex structures in a selective way have gained impressive interest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadf931d1461f83bd6ec0e80b80096f0
https://doi.org/10.1039/d0cp01483d

Role of fast dynamics in the complexation of G-quadruplexes with small molecules

Autor: Luca Bertini, Valeria Libera, Francesca Ripanti, Tilo Seydel, Marco Paolantoni, Andrea Orecchini, Caterina Petrillo, Lucia Comez, Alessandro Paciaroni

Schematic representation of our energy landscape model to describe the fast dynamics of human telomeric G-quadruplex and its change upon ligand complexation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda259616f518cafcc18ed3d385ec99b
https://hdl.handle.net/11391/1541493

Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure

Autor: Aurelien Thureau, M. Longo, Anne Martel, Alessandro Paciaroni, Caterina Petrillo, Valeria Libera, Giorgio Schirò, Lucia Comez, Elena A. Andreeva

Publikováno v: Journal of Physical Chemistry Letters
Journal of Physical Chemistry Letters, American Chemical Society, 2021, 12 (33), pp.8096-8102. ⟨10.1021/acs.jpclett.1c01840⟩
Journal of Physical Chemistry Letters, 2021, 12 (33), pp.8096-8102. ⟨10.1021/acs.jpclett.1c01840⟩
Libera, V, Andreeva, E A, Martel, A, Thureau, A, Longo, M, Petrillo, C, Paciaroni, A, Schiro, G & Comez, L 2021, ' Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure ', Journal of Physical Chemistry Letters, vol. 12, no. 33, pp. 8096-8102 . https://doi.org/10.1021/acs.jpclett.1c01840

International audience; Nucleic acid sequences rich in guanines can organize into noncanonical DNA G-quadruplexes (G4s) of variable size. The design of small molecules stabilizing the structure of G4s is a rapidly growing area for the development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5db6f017436dba3641ee7e616c14d4e
https://hal.univ-grenoble-alpes.fr/hal-03385962

The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors

Autor: Antonino Lauria, Lucia Comez, Lucrezia Savini, Yuri Gerelli, Francesco Spinozzi, Antonio Palumbo Piccionello, Paola Marzullo, Lucia Silvestrini, Norhan Belhaj, Alessandro Paciaroni, Caterina Petrillo, Paolo Mariani, Valeria Libera, Maria Grazia Ortore

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)

The maturation of coronavirus SARS-CoV-2, which is the etiological agent at the origin of the COVID-19 pandemic, requires a main protease Mpro to cleave the virus-encoded polyproteins. Despite a wealth of experimental information already available, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1749c005f95184aa52d1740f622a2fce
http://hdl.handle.net/10447/513816