Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Valeria Leuci"'
Autor:
Lidia Giraudo, Giulia Cattaneo, Loretta Gammaitoni, Ilenia Iaia, Chiara Donini, Annamaria Massa, Maria Laura Centomo, Marco Basiricò, Elisa Vigna, Alberto Pisacane, Franco Picciotto, Enrico Berrino, Caterina Marchiò, Alessandra Merlini, Luca Paruzzo, Stefano Poletto, Daniela Caravelli, Andrea Michela Biolato, Valentina Bortolot, Elisa Landoni, Marco Ventin, Cristina R. Ferrone, Massimo Aglietta, Gianpietro Dotti, Valeria Leuci, Fabrizio Carnevale-Schianca, Dario Sangiolo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-13 (2023)
Abstract Background Even acknowledging the game-changing results achieved in the treatment of metastatic melanoma with the use of immune checkpoint inhibitors (ICI), a large proportion of patients (40–60%) still fail to respond or relapse due to th
Externí odkaz:
https://doaj.org/article/3eb42d63a9594f5d95b1ee9f44199df2
Autor:
Cristina Chiriaco, Chiara Donini, Marco Cortese, Stefano Ughetto, Chiara Modica, Ilaria Martinelli, Alessia Proment, Letizia Vitali, Lara Fontani, Monica Casucci, Paolo Maria Comoglio, Silvia Giordano, Dario Sangiolo, Valeria Leuci, Elisa Vigna
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Aberrant activation of the MET receptor in cancer is sustained by genetic alterations or, more frequently, by transcriptional upregulations. A fraction of MET-amplified or mutated tumors are sensible to MET targeting agents, but t
Externí odkaz:
https://doaj.org/article/22b9bdbe382b4ee3a99b1a5d5a6d5557
Autor:
Giorgia Giordano, Alessandra Merlini, Giulio Ferrero, Giulia Mesiano, Erika Fiorino, Silvia Brusco, Maria Laura Centomo, Valeria Leuci, Lorenzo D’Ambrosio, Massimo Aglietta, Dario Sangiolo, Giovanni Grignani, Ymera Pignochino
Publikováno v:
Cells, Vol 10, Iss 11, p 2893 (2021)
Bone sarcomas are a group of heterogeneous malignant mesenchymal tumors. Complete surgical resection is still the cornerstone of treatment, but, in the advanced/unresectable setting, their management remains challenging and not significantly improved
Externí odkaz:
https://doaj.org/article/779f34e736fa4de89f800e07e0ab3ebf
Autor:
Chiara Donini, Ramona Rotolo, Alessia Proment, Massimo Aglietta, Dario Sangiolo, Valeria Leuci
Publikováno v:
Cells, Vol 10, Iss 3, p 543 (2021)
The term “cancer stem cells” (CSCs) commonly refers to a subset of tumor cells endowed with stemness features, potentially involved in chemo-resistance and disease relapses. CSCs may present peculiar immunogenic features influencing their homeost
Externí odkaz:
https://doaj.org/article/6bc934d746e449b793e22ccc74b35891
Autor:
Giulia Mesiano, Giovanni Grignani, Erika Fiorino, Valeria Leuci, Ramona Rotolo, Lorenzo D’Ambrosio, Chiara Salfi, Loretta Gammaitoni, Lidia Giraudo, Alberto Pisacane, Sara Butera, Ymera Pignochino, Marco Basiricó, Federica Capozzi, Anna Sapino, Massimo Aglietta, Dario Sangiolo
Publikováno v:
OncoImmunology, Vol 7, Iss 11 (2018)
Metastatic bone and soft tissue sarcomas often relapse after chemotherapy (CHT) and molecular targeted therapy (mTT), maintaining a severe prognosis. A subset of sarcoma cancer stem cells (sCSC) is hypothesized to resist conventional drugs and sustai
Externí odkaz:
https://doaj.org/article/b80f241c9a02442ba99be91d08bc6b0f
Autor:
Ramona Rotolo, Valeria Leuci, Chiara Donini, Federica Galvagno, Annamaria Massa, Maria Chiara De Santis, Serena Peirone, Giovanni Medico, Martina Sanlorenzo, Igor Vujic, Loretta Gammaitoni, Marco Basiricò, Luisella Righi, Chiara Riganti, Iris Chiara Salaroglio, Francesca Napoli, Fabrizio Tabbò, Annapaola Mariniello, Elisa Vigna, Chiara Modica, Lorenzo D’Ambrosio, Giovanni Grignani, Riccardo Taulli, Emilio Hirsch, Matteo Cereda, Massimo Aglietta, Giorgio Vittorio Scagliotti, Silvia Novello, Paolo Bironzo, Dario Sangiolo
Publikováno v:
Clinical Cancer Research. 29:621-634
Purpose: Antibodies against the lymphocyte PD-1 (aPD-1) receptor are cornerstone agents for advanced non–small cell lung cancer (NSCLC), based on their ability to restore the exhausted antitumor immune response. Our study reports a novel, lymphocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf52af420776a90fe006bc3d7d9c5ad
https://doi.org/10.1158/1078-0432.ccr-22-0761
https://doi.org/10.1158/1078-0432.ccr-22-0761
Autor:
Paola Circosta, Chiara Donini, Susanna Gallo, Lidia Giraudo, Loretta Gammaitoni, Ramona Rotolo, Federica Galvagno, Sonia Capellero, Marco Basiricò, Monica Casucci, Massimo Aglietta, Ivana Ferrero, Franca Fagioli, Alessandro Cignetti, Fabrizio Carnevale‐Schianca, Valeria Leuci, Dario Sangiolo
Publikováno v:
British Journal of Haematology. 200:64-69
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffb59033fe7346980cebd645e60b2224
https://doi.org/10.1111/bjh.18469
https://doi.org/10.1111/bjh.18469
Autor:
Dario Sangiolo, Paolo Bironzo, Silvia Novello, Giorgio Vittorio Scagliotti, Massimo Aglietta, Matteo Cereda, Emilio Hirsch, Riccardo Taulli, Giovanni Grignani, Lorenzo D’Ambrosio, Chiara Modica, Elisa Vigna, Annapaola Mariniello, Fabrizio Tabbò, Francesca Napoli, Iris Chiara Salaroglio, Chiara Riganti, Luisella Righi, Marco Basiricò, Loretta Gammaitoni, Igor Vujic, Martina Sanlorenzo, Giovanni Medico, Serena Peirone, Maria Chiara De Santis, Annamaria Massa, Federica Galvagno, Chiara Donini, Valeria Leuci, Ramona Rotolo
PD-L1/2 and phospho-p38 MAPK expression in NSCLC cells. Tumor membrane expression of PD-L1 and PD-L2 in NSCLC cell lines was intensely enhanced by treatment with Interferon γ (n=9, PD-L1 p=0.02, PD-L2 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6ec0bb3274f7c4bc99b140f2b8f43f
https://doi.org/10.1158/1078-0432.22489961.v1
https://doi.org/10.1158/1078-0432.22489961.v1
Autor:
Dario Sangiolo, Paolo Bironzo, Silvia Novello, Giorgio Vittorio Scagliotti, Massimo Aglietta, Matteo Cereda, Emilio Hirsch, Riccardo Taulli, Giovanni Grignani, Lorenzo D’Ambrosio, Chiara Modica, Elisa Vigna, Annapaola Mariniello, Fabrizio Tabbò, Francesca Napoli, Iris Chiara Salaroglio, Chiara Riganti, Luisella Righi, Marco Basiricò, Loretta Gammaitoni, Igor Vujic, Martina Sanlorenzo, Giovanni Medico, Serena Peirone, Maria Chiara De Santis, Annamaria Massa, Federica Galvagno, Chiara Donini, Valeria Leuci, Ramona Rotolo
Treatment with PD-L1s is associated with the up-regulation of expression of key protein coding genes involved in processes of tumorigenesis, EMT, tumor aggressiveness and chemoresistance. Heatmap showing z-scaled DESeq2-normalized expression values o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51261ae562e9aeda6258ca8dca6fdd30
https://doi.org/10.1158/1078-0432.22489964.v1
https://doi.org/10.1158/1078-0432.22489964.v1
Autor:
Dario Sangiolo, Paolo Bironzo, Silvia Novello, Giorgio Vittorio Scagliotti, Massimo Aglietta, Matteo Cereda, Emilio Hirsch, Riccardo Taulli, Giovanni Grignani, Lorenzo D’Ambrosio, Chiara Modica, Elisa Vigna, Annapaola Mariniello, Fabrizio Tabbò, Francesca Napoli, Iris Chiara Salaroglio, Chiara Riganti, Luisella Righi, Marco Basiricò, Loretta Gammaitoni, Igor Vujic, Martina Sanlorenzo, Giovanni Medico, Serena Peirone, Maria Chiara De Santis, Annamaria Massa, Federica Galvagno, Chiara Donini, Valeria Leuci, Ramona Rotolo
Double positive OCT3/4-PD1 subsets in the bulk NSCLC cells after cisplatin treatment. OCT3/4 expression preferentially co-localized on PD-1+ NSCLC cells as compared with the PD-1- counterpart (14% vs 0.1%). Representative flow cytometry histograms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8bee94264097ec1c6030380045f780
https://doi.org/10.1158/1078-0432.22489967.v1
https://doi.org/10.1158/1078-0432.22489967.v1