Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Valeria Gradinati"'
1
Efficacy and Selectivity of Monovalent and Bivalent Vaccination Strategies to Protect against Exposure to Carfentanil, Fentanyl, and Their Mixtures in Rats
Autor: Bethany Crouse, Mariah M. Wu, Valeria Gradinati, Andrew J. Kassick, Daihyun Song, Rajwana Jahan, Saadyah Averick, Scott Runyon, Sandra D. Comer, Marco Pravetoni
Publikováno v: ACS Pharmacol Transl Sci
[Image: see text] Drug-related fatal overdoses have significantly increased in the past decade due to the widespread availability of illicit fentanyl and other potent synthetic opioids such as carfentanil. Deliberate or accidental consumption or expo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ca0f7202452fc21bffc599fe5d5441
https://doi.org/10.1021/acsptsci.1c00260
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2
Polymer-mediated delivery of vaccines to treat opioid use disorders and to reduce opioid-induced toxicity
Autor: Megan Laudenbach, Marco Pravetoni, Rasidul Amin, Santhi Abbaraju, Brian C. Gilger, Poonam Velagaleti, Federico Baruffaldi, Valeria Gradinati
Publikováno v: Vaccine
Vaccines offer a potential strategy to treat opioid use disorders (OUD) and to reduce the incidence of opioid-related overdoses. Vaccines induce opioid-specific polyclonal antibodies that selectively and effectively bind the target opioid and prevent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fc111b20adce2f4ece72d182976e58
https://doi.org/10.1016/j.vaccine.2020.05.027
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3
Preclinical Efficacy and Selectivity of Vaccines Targeting Fentanyl, Alfentanil, Sufentanil, and Acetylfentanyl in Rats
Autor: Carly Baehr, Christine Robinson, Andrew Kassick, Rajwana Jahan, Valeria Gradinati, Saadyah E. Averick, Scott P. Runyon, Marco Pravetoni
Publikováno v: ACS omega. 7(19)
The ongoing public health emergency of opioid use disorders (OUD) and overdose in the United States is largely driven by fentanyl and its related analogues and has resulted in over 75 673 deaths in 2021. Immunotherapeutics such as vaccines have been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621ed26d723470e4d1d6b36195839cd3
https://pubmed.ncbi.nlm.nih.gov/35601290
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6
Therapeutic and Prophylactic Vaccines to Counteract Fentanyl Use Disorders and Toxicity
Autor: Marina Kovaliov, Marco Pravetoni, Scott P. Runyon, Mark G. LeSage, Danni L. Harris, Sandra D. Comer, Saadyah Averick, Christine Robinson, Valeria Gradinati, Carly Baehr, Federico Baruffaldi, Bethany Crouse, Fatima Hamid
Publikováno v: Journal of medicinal chemistry. 63(23)
The incidence of fatal overdoses has increased worldwide due to the widespread access to illicit fentanyl and its potent analogues. Vaccines offer a promising strategy to reduce the prevalence of opioid use disorders (OUDs) and to prevent toxicity fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29697e3f76a81223b8a2d2b8233ee0dd
https://pubmed.ncbi.nlm.nih.gov/33215913
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9
Development of vaccines for treatment of opioid abuse using carrier proteins suitable for pharmaceutical manufacturing
Autor: April M. Huseby Kelcher, Valeria Gradinati, Ajinkya Limkar, Federico Baruffaldi, Andrew Lees, Marco Pravetoni
Publikováno v: The Journal of Immunology. 200:181.28-181.28
In 2016, over 50,000 people died in the US from heroin and prescription opioid related overdoses. Current standard of care is not sufficient. Therapeutic vaccines against opioids are safe, long-lasting, and cost-effective alternatives to opioid-based
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc02bf3cec1c4aef8f24c5309324fe2c
https://doi.org/10.4049/jimmunol.200.supp.181.28
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