Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Valeria Follia"'
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Akademický článek
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
Autor: Jacqueline H. L. Fok, Antonio Ramos-Montoya, Mercedes Vazquez-Chantada, Paul W. G. Wijnhoven, Valeria Follia, Neil James, Paul M. Farrington, Ankur Karmokar, Sophie E. Willis, Jonathan Cairns, Jenni Nikkilä, David Beattie, Gillian M. Lamont, M. Raymond V. Finlay, Joanne Wilson, Aaron Smith, Lenka Oplustil O’Connor, Stephanie Ling, Stephen E. Fawell, Mark J. O’Connor, Simon J. Hollingsworth, Emma Dean, Frederick W. Goldberg, Barry R. Davies, Elaine B. Cadogan
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
DNA-dependent protein kinase (DNA-PK) plays a major role in the DNA damage response upon double-strand break formation. Here, the authors show that the DNA-PK inhibitor AZD7648, enhances the activity of radiotherapy, chemotherapy and the PARP inhibit
Externí odkaz: https://doaj.org/article/7547983126794fc0a17cf1c4d462a298
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2
Abstract 626: Mechanistic differentiation of targeted DDR agent combinations
Autor: Mark J. O'Connor, Paul Wijnhoven, Stephen T. Durant, Zena Wilson, Elaine Cadogan, Josep V. Forment, Elisabetta Leo, Rajesh Oderda, Alan Lau, Antonio Ramos-Montoya, Mercedes Vazquez-Chantada, Valeria Follia, Jacqueline H. L. Fok
Publikováno v: Cancer Research. 80:626-626
The DNA damage response (DDR) safeguards genome stability and promotes cellular survival by counteracting deleterious consequences of DNA damage. Deficiencies in DDR pathways contribute to genome instability, a hallmark of cancer development, and tar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60fcc55fd581425c62ea795b36d6b62a
https://doi.org/10.1158/1538-7445.am2020-626
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3
Fluorinated Fe(III) Salophene Complexes: Optimization of Tumor Cell Specific Activity and Utilization of Fluorine Labeling for in Vitro Analysis
Autor: Brigitte Flögel, Christiane Cwikla, Ronald Gust, Fanni Lerch, Irene Würtenberger, Christina Kalchschmidt, Brigitte Kircher, Valeria Follia, Nathalie Fahrner
Publikováno v: Journal of Medicinal Chemistry. 58:588-597
Fluorine-substituted iron(III) salophene complexes (salophene = N,N'-bis(salicylidene)-1,2-phenylenediamine) were synthesized and evaluated for biological activity. All complexes showed growth inhibitory effects with IC50 values ranging from 0.05 to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c08d02cccbbaefcbaa9e6d175c23cb
https://doi.org/10.1021/jm500986h
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Abstract 3505: AZD7648: A potent and selective inhibitor of DNA-PK with pharmacodynamic and monotherapy anti-tumor activity
Autor: Emma Dean, Antonio Ramos-Montoya, Elaine Cadogan, Jacqueline H. L. Fok, Lenka Oplustil O'Connor, Barry R. Davies, Neil H. James, Paul Winjhoven, Valeria Follia, Ankur Karmokar, Anna Staniszewska, Mercedes Vazquez-Chantada, Simon J. Hollingsworth
Publikováno v: Cancer Research. 79:3505-3505
DNA-dependent kinase (DNA-PK) is a nuclear serine/threonine protein kinase complex that is a key component of the non-homologous end joining (NHEJ) process. DNA-PK plays an important role in the cellular response to DNA damage through the detection a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3da36654f442068097cfc48c3d5f6e7
https://doi.org/10.1158/1538-7445.am2019-3505
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Synthesis and characterization of thiazolo- and thiazinomorphinans and their intermediate products as novel opioid-active derivatives
Autor: Helmut Schmidhammer, Attila Sipos, Sándor Berényi, Valeria Follia, Mariana Spetea, Sándor Antus
Publikováno v: Archiv der Pharmazie. 345(11)
A new procedure was elaborated for the synthesis of potentially opioid-active thiazolo- and thiazinomorphinans. These derivatives and some intermediates related with the synthesis were tested in opioid receptor binding studies. Two compounds showed r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3924f22bb4f4d833e144987c37515ec4
https://pubmed.ncbi.nlm.nih.gov/22886624
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Introduction of a 6-cyano group in 14-oxygenated N-methylmorphinans influences in vitro and in vivo pharmacological activities
Autor: Louis S. Harris, Helmut Schmidhammer, Mariana Spetea, Valeria Follia, Mario D. Aceto, Andrew Coop
Publikováno v: BMC Pharmacology
Background Being a disabling symptom of many medical conditions, effective pain control is one of the most important therapeutic priorities. Morphine and other opioid drugs produce analgesia primarily through μ opioid (MOP) receptors, which mediate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ef635b95c2fed16a309e513258b94c
http://europepmc.org/articles/PMC3194259
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Biological, pharmacological and immunological activities of novel 6-amino-acid-substituted 14-alkoxy-N-methylmorphinans
Autor: Monika Fink, Silvia Rief, Muhammad Faheem Asim, Dorota Garczarczyk, Valeria Follia, Helmut Schmidhammer, Mariana Spetea, Elena Guerrieri
Publikováno v: BMC Pharmacology
Background Of the three opioid receptors, μ (MOP), δ (DOP) and (KOP), the MOP type is the most involved in the action of opioids in the gut. Experimental studies on models of intestinal inflammation and inflammatory bowel disease (IBD) support an a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1935dfe9c75aa595acf75c653ede783a
http://europepmc.org/articles/PMC3194285
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