Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Valeria Facchinetti"'
Autor:
Yong-Jun Liu, Jodi L. Karnell, Santosh K. Panda, Miguel A. Sanjuan, Shino Hanabuchi, Elisaveta Voynova, Rachel Ettinger, Richard N. Hanna, Roland Kolbeck, Valeria Facchinetti
Publikováno v:
Journal of Clinical Investigation. 128:1873-1887
Uncontrolled secretion of type I IFN, as the result of endosomal TLR (i.e., TLR7 and TLR9) signaling in plasmacytoid DCs (pDCs), and abnormal production of autoantibodies by B cells are critical for systemic lupus erythematosus (SLE) pathogenesis. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f229013938c1baaf4e821f41db89eba3
https://doi.org/10.1172/jci97333
https://doi.org/10.1172/jci97333
Autor:
Shino Hanabuchi, Laura Bover, Tomasz Zal, Yong-Jun Liu, Amjad H. Talukder, Valeria Facchinetti, Musheng Bao, Tae Whan Kim
Publikováno v:
Cell Research. 22:1129-1139
Toll-like receptor 9 (TLR9) senses microbial DNA in the endosomes of plasmacytoid dendritic cells (pDCs) and triggers MyD88-dependent type I interferon (IFN) responses. To better understand TLR9 biology in pDCs, we established a yeast two-hybrid libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe370ae35cde152830549957c51017cb
https://doi.org/10.1038/cr.2012.45
https://doi.org/10.1038/cr.2012.45
Autor:
Francesco Vetrini, David M. Sabatini, Gerard Karsenty, Tuong Huynh, Andrea Ballabio, Mathieu Ferron, Serkan Erdin, Diego L. Medina, Roberto Zoncu, Carmine Settembre, Valeria Facchinetti, Michel C. Vellard, SerpilUckac Erdin
Publikováno v:
The EMBO Journal. 31:1095-1108
The lysosome plays a key role in cellular homeostasis by controlling both cellular clearance and energy production to respond to environmental cues. However, the mechanisms mediating lysosomal adaptation are largely unknown. Here, we show that the Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a4d54c1572f8d6b4666a1d4b3ccc4dd
https://doi.org/10.1038/emboj.2012.32
https://doi.org/10.1038/emboj.2012.32
Autor:
Laura Bover, Taeil Kim, Jun Qin, Musheng Bao, Joel Plumas, Valeria Facchinetti, Yong-Jun Liu, Shwetha Pazhoor, Zhiqiang Zhang, Laurence Chaperot, Shino Hanabuchi
Publikováno v:
Proceedings of the National Academy of Sciences. 107:15181-15186
Toll-like receptor 9 (TLR9) senses microbial DNA and triggers type I IFN responses in plasmacytoid dendritic cells (pDCs). Previous studies suggest the presence of myeloid differentiation primary response gene 88 (MyD88)-dependent DNA sensors other t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfb76a3a94f1349f7d57e63bf8714b3
https://doi.org/10.1073/pnas.1006539107
https://doi.org/10.1073/pnas.1006539107
Autor:
Michael Karin, Gerry Melino, Ewen Gallagher, Valeria Facchinetti, Thomas Enzler, Bing Su, Xing Chang
Publikováno v:
The Journal of Immunology. 183:3831-3838
MEKK1-dependent signaling regulates HECT E3 ligase Itch, resulting in elevated catalytic activity. After TCR costimulation, MEKK1 predominantly induces JNK1 activation, whereas the related kinase MEKK2 regulates ERK5 activation. MEKK1 becomes phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534fce4e3a7db02281de818f9b1a794d
https://doi.org/10.4049/jimmunol.0803412
https://doi.org/10.4049/jimmunol.0803412
Publikováno v:
The EMBO Journal. 25:97-107
Members of the mitogen-activated protein kinase kinase kinase (MAP3K) family are crucial for the Toll-like receptor (TLR) signaling and cellular stress responses. However, the molecular mechanisms underlying the TLR- and cellular stress-mediated MAP3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057cd0cd948c4f5006106de2e744c8f1
https://doi.org/10.1038/sj.emboj.7600913
https://doi.org/10.1038/sj.emboj.7600913
Autor:
Samantha Seresini, Maria Pia Protti, Claudio Garavaglia, Renato Longhi, Valeria Facchinetti, Giulia Casorati
Publikováno v:
European Journal of Immunology. 35:806-815
Infection by 'high-risk' human papillomaviruses (HPV) is associated with the development of neoplastic lesions. HPV-18 is responsible for a very aggressive form of cancer and poor survival. As for other HPV types, immune surveillance has probably a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd963be53566fbbefc01e83a68f52256
https://doi.org/10.1002/eji.200425699
https://doi.org/10.1002/eji.200425699
Autor:
Valeria Facchinetti, Francesca Granucci, Paola Ricciardi-Castagnoli, Stefania Citterio, Antonio Lanzavecchia, Samantha Seresini, Sonia Feau, David Jarrossay, Maria Pia Protti
Publikováno v:
Blood. 105:697-702
Dendritic cells (DCs) are involved in the initiation and regulation of innate and adaptive immune responses. Several molecular mechanisms regulate these diverse DC functions, and we have previously reported that mouse dendritic cells (mDCs) can produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76abf04886b18d7890fb7fbcee2c5941
https://doi.org/10.1182/blood-2004-03-1059
https://doi.org/10.1182/blood-2004-03-1059
Autor:
Rosanna Gramigna, Josée Golay, Martino Introna, Valeria Facchinetti, Daniela Capello, Gianluca Gaidano
Publikováno v:
British Journal of Haematology. 119:923-929
Rituximab (Mabthera) and alemtuzumab (Campath(R), Mabcampath(R)) are non-conjugated IgG1 therapeutic monoclonal antibodies directed against the CD20 and CD52 surface antigens respectively. They are presently used in the therapy of indolent B-cell non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f353415ae2c5ece9781f32a1f218f5e
https://doi.org/10.1046/j.1365-2141.2002.03935.x
https://doi.org/10.1046/j.1365-2141.2002.03935.x
Autor:
Megan Lundell Harline, Larry W. Kwak, Laura Bover, Long T. Vien, Valeria Facchinetti, Yong J. Liu, Kazuhiko Arima, Kui S. Voo
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 191(7)
Current cancer vaccines induce tumor-specific T cell responses without sustained tumor regression because immunosuppressive elements within the tumor induce exhaustion of effector T cells and infiltration of immune-suppressive regulatory T cells (Tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e628e8fafa95594487eb0a883f53313
https://pubmed.ncbi.nlm.nih.gov/24014877
https://pubmed.ncbi.nlm.nih.gov/24014877