Glycol Chitosan Functionalized with a Gd(III) Chelate as a Redox‐responsive Magnetic Resonance Imaging Probe to Label Cell Embedding Alginate Capsules

Autor: Giuseppe Digilio, Valeria Catanzaro, Malvina Koni, Sergio Padovan, Cristina Grange, Carla Carrera

Publikováno v: Chemistry – A European Journal. 27:12289-12293

One possibility for the non-invasive imaging of encapsulated cell grafts is to label the lumen of cell embedding capsules with a redox-responsive probe, as an increased extracellular reducing potential can be considered as a marker of hypoxia-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4047c39d32da0b48989464e642b58ec8
https://doi.org/10.1002/chem.202101657

First in vivo MRI study on theranostic dendrimersomes

Autor: Miriam Filippi, Mauro Botta, Deyssy Patrucco, Lorenzo Tei, Enzo Terreno, Valeria Catanzaro

Publikováno v: Journal of Controlled Release. 248:45-52

Amphiphilic Janus-dendrimers are able to self-assemble into nanosized vesicles named dendrimersomes. We recently synthesized the 3,5-C12-EG-(OH)4 dendrimer that generates dendrimersomes with very promising safety and stability profiles, that can be l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3da3733f84536720d511738f581aae
https://doi.org/10.1016/j.jconrel.2017.01.010

Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up

Autor: Stefano Porta, Giuseppe Digilio, Cristina Grange, Carla Carrera, Valeria Catanzaro, Sergio Padovan, Monica Muñoz Úbeda, Fabio Carniato, Lorenzo Tei

Publikováno v: Chemistry - A European Journal. 22:7716-7720

The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been deco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303d7329e94a686bd43fbcc852048760
https://doi.org/10.1002/chem.201600962

Enzyme-Responsive LipoCEST Agents: Assessment of MMP-2 Activity by Measuring the Intra-liposomal Water

Autor: Giuseppe, Ferrauto, Enza, Di Gregorio, Marta, Ruzza, Valeria, Catanzaro, Sergio, Padovan, Silvio, Aime

Publikováno v: Angewandte Chemie (International ed. in English). 56(40)

Mobile proton-containing solutes can be detected by MRI by the chemical exchange saturation transfer (CEST) method. CEST sensitivity is dramatically enhanced by using, as exchanging protons, the water molecules confined inside liposomes, shifted by a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d3c3a0e2e8ebdf24717195557744735c
https://pubmed.ncbi.nlm.nih.gov/28746744

AR2p/R1pRatiometric Procedure to Assess Matrix Metalloproteinase-2 Activity by Magnetic Resonance Imaging

Autor: Giuseppe Digilio, Valeria Catanzaro, Cinzia Boffa, Silvio Aime, Walter Dastrù, Concetta V. Gringeri, Valeria Menchise, Sergio Padovan, Linda Chaabane

Publikováno v: Angewandte Chemie International Edition 52 (2013): 3926–3930. doi:10.1002/anie.201209286
info:cnr-pdr/source/autori:Catanzaro V.; Gringeri C.V.; Menchise V.; Padovan S.; Boffa C.; Dastru W.; Chaabane L.; Digilio G.; Aime S./titolo:A R2p%2FR1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging/doi:10.1002%2Fanie.201209286/rivista:Angewandte Chemie International Edition/anno:2013/pagina_da:3926/pagina_a:3930/intervallo_pagine:3926–3930/volume:52

The approach to molecular imaging of enzymes by MRI typically relies upon imaging probes composed of an enzymecleavable moiety conjugated with a paramagnetic imaging reporter, such as a GdIII chelate.[1] Upon enzymatic processing, the probe is transf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08e9477b6e933582aa3d54911d7e00a
https://doi.org/10.1002/ange.201209286