Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Valeria, Francesconi"'
Autor:
Ilaria Giacchello, Annarita Cianciusi, Chiara Bertagnin, Anna Bonomini, Valeria Francesconi, Mattia Mori, Anna Carbone, Francesca Musumeci, Arianna Loregian, Silvia Schenone
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 954 (2024)
The limited range of available flu treatments due to virus mutations and drug resistance have prompted the search for new therapies. RNA-dependent RNA polymerase (RdRp) is a heterotrimeric complex of three subunits, i.e., polymerase acidic protein (P
Externí odkaz:
https://doaj.org/article/c6335ef946f64501a6e9753dc49c8aac
Autor:
Elena Cichero, Valeria Francesconi, Beatrice Casini, Monica Casale, Evgeny Kanov, Andrey S. Gerasimov, Ilya Sukhanov, Artem Savchenko, Stefano Espinoza, Raul R. Gainetdinov, Michele Tonelli
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1632 (2023)
Trace amine-associated receptor 1 (TAAR1) is an attractive target for the design of innovative drugs to be applied in diverse pharmacological settings. Due to a non-negligible structural similarity with endogenous ligands, most of the agonists develo
Externí odkaz:
https://doaj.org/article/838a4c08d80445b0bfd216925fa9f94f
Autor:
Federica Barbieri, Alessia Graziana Bosio, Alessandra Pattarozzi, Michele Tonelli, Adriana Bajetto, Ivan Verduci, Francesca Cianci, Gaetano Cannavale, Luca M. G. Palloni, Valeria Francesconi, Stefano Thellung, Pietro Fiaschi, Samanta Mazzetti, Silvia Schenone, Beatrice Balboni, Stefania Girotto, Paolo Malatesta, Antonio Daga, Gianluigi Zona, Michele Mazzanti, Tullio Florio
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-27 (2022)
Abstract Background Chloride intracellular channel-1 (CLIC1) activity controls glioblastoma proliferation. Metformin exerts antitumor effects in glioblastoma stem cells (GSCs) inhibiting CLIC1 activity, but its low potency hampers its translation in
Externí odkaz:
https://doaj.org/article/7b56612354df4a31ad989eb52608dd88
Autor:
Cecilia Pozzi, Anne Vanet, Valeria Francesconi, Lorenzo Tagliazucchi, Giusy Tassone, Alberto Venturelli, Francesca Spyrakis, Marco Mazzorana, Maria P. Costi, Michele Tonelli
Publikováno v:
Journal of Medicinal Chemistry. 66:3664-3702
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e648a87200b7bea42bec4fe625092a
https://doi.org/10.1021/acs.jmedchem.2c01229
https://doi.org/10.1021/acs.jmedchem.2c01229
Autor:
Francine Medjiofack Djeujo, Valeria Francesconi, Maddalena Gonella, Eugenio Ragazzi, Michele Tonelli, Guglielmina Froldi
Publikováno v:
Molecules, Vol 27, Iss 2, p 547 (2022)
Diabetes mellitus is characterized by chronic hyperglycemia that promotes ROS formation, causing severe oxidative stress. Furthermore, prolonged hyperglycemia leads to glycation reactions with formation of AGEs that contribute to a chronic inflammato
Externí odkaz:
https://doaj.org/article/70b7a0ec693644c29fe6da446901852d
Autor:
Elena Cichero, Alessio Calautti, Valeria Francesconi, Michele Tonelli, Silvia Schenone, Paola Fossa
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1307 (2021)
Targeting the fusion (F) protein has been recognized as a fruitful strategy for the development of anti-RSV agents. Despite the considerable efforts so far put into the development of RSV F protein inhibitors, the discovery of adequate therapeutics f
Externí odkaz:
https://doaj.org/article/453075f856014baf84057f62874d942d
Autor:
Giusy Tassone, Giacomo Landi, Pasquale Linciano, Valeria Francesconi, Michele Tonelli, Lorenzo Tagliazucchi, Maria Paola Costi, Stefano Mangani, Cecilia Pozzi
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 636 (2021)
Trypanosoma and Leishmania parasites are the etiological agents of various threatening neglected tropical diseases (NTDs), including human African trypanosomiasis (HAT), Chagas disease, and various types of leishmaniasis. Recently, meaningful progres
Externí odkaz:
https://doaj.org/article/70e738fa89394bc7959ea50a78f26d41
Publikováno v:
Pharmaceuticals, Vol 14, Iss 1, p 33 (2021)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is characterized by memory loss, cognitive impairment, and functional decline leading to dementia and death. AD imposes neuronal death by the intricate interplay of different
Externí odkaz:
https://doaj.org/article/d0affbd0bcc345b0ab94941d4b802344
Autor:
Valeria Francesconi, Elena Cichero, Evgeny V. Kanov, Erik Laurini, Sabrina Pricl, Raul R. Gainetdinov, Michele Tonelli
Publikováno v:
Pharmaceuticals, Vol 13, Iss 11, p 391 (2020)
Targeting trace amine-associated receptor 1 (TAAR1) receptor continues to offer an intriguing opportunity to develop innovative therapies in different pharmacological settings. Pursuing our endeavors in the search for effective and safe human TAAR1 (
Externí odkaz:
https://doaj.org/article/9983f73abffa474a9c8342091b5c9e47
Publikováno v:
Molecules, Vol 25, Iss 7, p 1487 (2020)
Respiratory RNA viruses are responsible for recurrent acute respiratory illnesses that still represent a major medical need. Previously we developed a large variety of benzimidazole derivatives able to inhibit these viruses. Herein, two series of (th
Externí odkaz:
https://doaj.org/article/4a1f722db7274616b0a451b77dd4524c