Comparison of the Efficacy of Brolucizumab with Natural Disease Progression in Wet AMD Using Clinical Data from the Phase III HAWK and HARRIER Trials and Modelled Placebo Data

Autor: Miltiadis K. Tsilimbaris, Andreas Clemens, Zufar Mulyukov, Etienne Pigeolet, Valeria Colafrancesco, David Gaucher, Hansjürgen Agostini, Felicitas Bucher, Pilar Calvo

Publikováno v: Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname

Aim: To compare the treatment effect of brolucizumab, a novel anti-vascular endothelial growth factor therapeutic, with a putative placebo in patients with wet age-related macular degeneration. Materials and Methods: Clinical treatment-effect data fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917d4c67b1909966f7bed4448946dd86
https://doi.org/10.1080/02713683.2020.1731832

Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation

Autor: Mar Masso, Noelia López-Sánchez, Karen Lariosa-Willingham, Lawrence Steinman, Valeria Colafrancesco, Raquel Vázquez, Jason C. Dugas, Dmitri Leonoudakis, Gemma Vila, Ernest Giralt, Angel Messeguer, Beatriz Moreno, Irati Zubizarreta, Gloria Vendrell-Navarro, José María Frade, Irene Pulido-Valdeolivas, Joaquin Messeguer, Meritxell Teixidó, Pablo Villoslada, Inna Pertsovskaya, Begoña Fernandez-Diez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Neurotherapeutics

The development of neuroprotective therapies is a sought-after goal. By screening combinatorial chemical libraries using in vitro assays, we identified the small molecule BN201 that promotes the survival of cultured neural cells when subjected to oxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c99c6190a7de7c33d3837eb1019277e
http://hdl.handle.net/10261/203085

Persistent Activation of Nuclear Factor Kappa-B Signaling Pathway in Patients With Unstable Angina and Elevated Levels of C-Reactive Protein

Autor: Giovanna Liuzzo, Annalisa Porto, Matteo Santamaria, Luigi M. Biasucci, Michela Pinnelli, Attilio Maseri, Valeria Colafrancesco, Vittoria Rizzello, Filippo Crea, Michela Narducci, Salvatore Brugaletta

Publikováno v: Journal of the American College of Cardiology. 49:185-194

Objectives Our study investigated: 1) the contribution of nuclear factor kappa-B (NF-κB) signaling pathway to the enhanced inflammatory response observed in unstable angina (UA) patients with elevated levels of C-reactive protein (CRP); and 2) wheth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a2f2b074b9f4fab462f7e7c529fa73
https://doi.org/10.1016/j.jacc.2006.07.071

Targeting NGF pathway for developing neuroprotective therapies for multiple sclerosis and other neurological diseases

Autor: Valeria, Colafrancesco, Pablo, Villoslada

Publikováno v: Archives italiennes de biologie. 149(2)

Inflammation is the first line of defense against injury and infection and works both by controlling the ongoing pathological processes and by promoting neuroprotection and regeneration. When the inflammatory response is hyper activated, it plays a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e323baebe9308f4a9a4923c867792acc
https://pubmed.ncbi.nlm.nih.gov/21701990

Anti-NGF-antibody administration as collyrium reduces the presence of NGF and enhances the expression of VEGF in the retina, lacrimal gland and hippocampus

Autor: Luigi Aloe, Valeria Colafrancesco, Francesca Cirulli, Alessandra Berry, Simona Rossi

Publikováno v: Neuroscience letters. 463(3)

In the present study we investigated the effects of eye anti-nerve growth factor (NGF)-antibody (ANA) application on the retina, lacrimal gland, and brain cells of aged mice. Mice were treated three times daily for three consecutive weeks with ANA or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc80c29a73c34f290d9b83223225f70
https://pubmed.ncbi.nlm.nih.gov/19651190