Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Valeria, Ciaffaglione"'
Autor:
Sebastiano Intagliata, Valeria Ciaffaglione, Valeria Consoli, Agata Grazia D'Amico, Luca Vanella, Valeria Pittalà, Federica Sodano, Marica Erminia Schiano, Valeria Sorrenti, Loredana Salerno
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100227- (2024)
Heme oxygenase-1 (HO-1) is involved in the oncogenesis of glioblastoma (GBM). In this work, we investigated for the first time how the co-administration (combo) of the HO-1 inhibitors SI1/09 or LS6/42 with temozolomide (TMZ) or temozolomide acid (TMZ
Externí odkaz:
https://doaj.org/article/8e09821e8da1442bbb50709288e645ac
Autor:
Montse Pérez-Fernández, Irene Suárez-Rojas, Xue Bai, Ignacio Martínez-Martel, Valeria Ciaffaglione, Valeria Pittalà, Loredana Salerno, Olga Pol
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1794 (2023)
Chronic pain caused by persistent inflammation is current in multiple diseases and has a strong negative impact on society. It is commonly associated with several mental illnesses, which can exert a negative influence on pain perception, and needs to
Externí odkaz:
https://doaj.org/article/e923ddf6868742af94fdf487923caca3
Autor:
Francesco Bellia, Valeria Lanza, Irina Naletova, Barbara Tomasello, Valeria Ciaffaglione, Valentina Greco, Sebastiano Sciuto, Pietro Amico, Rosanna Inturri, Susanna Vaccaro, Tiziana Campagna, Francesco Attanasio, Giovanni Tabbì, Enrico Rizzarelli
Publikováno v:
Antioxidants, Vol 12, Iss 8, p 1632 (2023)
A series of copper(II) complexes with the formula [Cu2+Hy(x)Car%] varying the molecular weight (MW) of Hyaluronic acid (Hy, x = 200 or 700 kDa) conjugated with carnosine (Car) present at different loading were synthesized and characterized via differ
Externí odkaz:
https://doaj.org/article/1a23f477b93147f688413a27bf50edfb
Autor:
Loredana Salerno, Luca Vanella, Valeria Sorrenti, Valeria Consoli, Valeria Ciaffaglione, Antonino N. Fallica, Vittorio Canale, Paweł Zajdel, Rosario Pignatello, Sebastiano Intagliata
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1377-1385 (2021)
In this work, the first mutual prodrug of 5-fluorouracil and heme oxygenase1 inhibitor (5-FU/HO-1 hybrid) has been designed, synthesised, and evaluated for its in vitro chemical and enzymatic hydrolysis stability. Predicted in silico physicochemical
Externí odkaz:
https://doaj.org/article/d08b3debd1ad442da383fcfbf840908f
Autor:
Valeria Ciaffaglione, Valeria Consoli, Sebastiano Intagliata, Agostino Marrazzo, Giuseppe Romeo, Valeria Pittalà, Khaled Greish, Luca Vanella, Giuseppe Floresta, Antonio Rescifina, Loredana Salerno, Valeria Sorrenti
Publikováno v:
Molecules, Vol 27, Iss 10, p 3220 (2022)
This paper reports on a novel series of tyrosine kinase inhibitors (TKIs) potentially useful for the treatment of chronic myeloid leukemia (CML). The newly designed and synthesized compounds are structurally related to nilotinib (NIL), a second-gener
Externí odkaz:
https://doaj.org/article/04d5594b9bda4cd4bfd90b74c5595aec
Autor:
Giuseppe Romeo, Valeria Ciaffaglione, Emanuele Amata, Maria Dichiara, Loredana Calabrese, Luca Vanella, Valeria Sorrenti, Salvo Grosso, Agata Grazia D’Amico, Velia D’Agata, Sebastiano Intagliata, Loredana Salerno
Publikováno v:
Molecules, Vol 26, Iss 13, p 3860 (2021)
Cancer is a multifactorial disease that may be tackled by targeting different signaling pathways. Heme oxygenase-1 (HO-1) and sigma receptors (σRs) are both overexpressed in different human cancers, including prostate and brain, contributing to the
Externí odkaz:
https://doaj.org/article/c7c17f4ae8db4615a7d882c9978e04ba
Autor:
Loredana Salerno, Valeria Ciaffaglione, Giuseppe Romeo, Sebastiano Intagliata, Maria N. Modica, Valeria Pittalà
Publikováno v:
ChemMedChem. 16:3496-3512
The development of potent antitumor agents with a low toxicological profile against healthy cells is still one of the greatest challenges facing in medicinal chemistry. In this context, the "mutual prodrug" approach has emerged as a potential tool to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429c9a8ba31d5c2a49958c58b1fea205
https://doi.org/10.1002/cmdc.202100473
https://doi.org/10.1002/cmdc.202100473
Autor:
Jonathan R. Dilworth, Helena C. Quilter, Gabriele Kociok-Köhn, Rüdiger M. Exner, Sophia Sarpaki, Fernando Cortezon-Tamarit, Sofia I. Pascu, Philip A. Waghorn, Ruggero Dondi, Ian M. Eggleston, Valeria Ciaffaglione, Haobo Ge, Stanley W. Botchway, Samuel P. Godfrey
Publikováno v:
Bioconjugate Chemistry
Over the past decade, porphyrin derivatives have emerged as invaluable synthetic building blocks and theranostic kits for the delivery of cellular fluorescence imaging and photodynamic therapy. Tetraphenylporphyrin (TPP), its metal complexes, and rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758379037a58e95d1c238a7b33b97dd1
http://europepmc.org/articles/PMC8299459
http://europepmc.org/articles/PMC8299459
Autor:
Antonino N, Fallica, Valeria, Ciaffaglione, Maria N, Modica, Valeria, Pittalà, Loredana, Salerno, Emanuele, Amata, Agostino, Marrazzo, Giuseppe, Romeo, Sebastiano, Intagliata
Publikováno v:
Bioorganicmedicinal chemistry. 73
The overexpression of σ receptors (σRs) in various types of tumors has prompted a deep investigation of their role in cancer pathophysiology. Consequently, σR ligands have been widely studied in vitro and in vivo for their antiproliferative effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc262cdcb7fffa6f61a4897323f6aba8
https://pubmed.ncbi.nlm.nih.gov/36202063
https://pubmed.ncbi.nlm.nih.gov/36202063
Autor:
Antonino N. Fallica, Valeria Ciaffaglione, Maria N. Modica, Valeria Pittalà, Loredana Salerno, Emanuele Amata, Agostino Marrazzo, Giuseppe Romeo, Sebastiano Intagliata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b048462f8cc3051b09d0ed908481d0c2
https://hdl.handle.net/20.500.11769/540800
https://hdl.handle.net/20.500.11769/540800
