Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Valer Jeso"'
Autor:
Valer Jeso, Kang Du, Arnold L. Rheingold, Zachary D. Stempel, Glenn C. Micalizio, Matthew J. Kier
Publikováno v:
J Am Chem Soc
A stereoselective entry to ryanoids is described that culminates in the synthesis of anhydroryanodol and thus the formal total synthesis of ryanodol. The pathway described features an annulation reaction conceived to address the uniquely complex and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607ae47c107527f946748f6d278c505f
https://doi.org/10.1021/jacs.0c05766
https://doi.org/10.1021/jacs.0c05766
Autor:
Mika Nakashige, Claudio Aquino, Glenn C. Micalizio, Valer Jeso, Haruki Mizoguchi, Xiayun Cheng
Publikováno v:
Journal of the American Chemical Society
Angularly substituted trans-fused hydroindanes are now accessible by the direct and convergent union of trimethylsilyl (TMS)-alkynes with 4-hydroxy-1,6-enynes by a process that forges three C–C bonds, one C–H bond, and two new stereocenters. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0da772e9aa7c7348caa229147ffbd74
https://doi.org/10.1021/ja504374j
https://doi.org/10.1021/ja504374j
Autor:
Philip LoGrasso, HaJeung Park, Pamela Hernandez, Valer Jeso, Glenn C. Micalizio, Michael D. Cameron, Sarah Iqbal
Publikováno v:
Angewandte Chemie. 125:4900-4904
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615c9396988236664efd96c3bae86b35
https://doi.org/10.1002/ange.201301323
https://doi.org/10.1002/ange.201301323
Publikováno v:
Angewandte Chemie. 117:3963-3967
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bc46934203741c0ba0c0b003211217
https://doi.org/10.1002/ange.200500776
https://doi.org/10.1002/ange.200500776
Autor:
Valer Jeso, Glenn C. Micalizio
Publikováno v:
Nature. 494:179-181
A boron complex catalyses the addition of allyl groups — hydrocarbon motifs — to 'activated imines' in a relay-like process, generating synthetically useful compounds as single mirror-image isomers. See Letter p.216 A team from the chemistry depa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::278b5110ffe671eb3b746748251d16e9
https://doi.org/10.1038/494179a
https://doi.org/10.1038/494179a
Autor:
Mika Nakashige, Claudio Aquino, Xiayun Cheng, Valer Jeso, Glenn C. Micalizio, Haruki Mizoguchi
Publikováno v:
ChemInform. 46
Hydroindanes are formed from TMS-alkynes and 4-hydroxy-1,6-enynes in the presence of Ti(OiPr)4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de4aa4a5955c3973392a957a0f00c093
https://doi.org/10.1002/chin.201502101
https://doi.org/10.1002/chin.201502101
Autor:
Michael D. Cameron, Scott Heyward, Gregory S. Walker, Valer Jeso, Glenn C. Micalizio, Xiaohai Li, Raman Sharma
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 42(3)
Almost half of prescription medications are metabolized by cytochrome P450 3A4 and 3A5. CYP3A4 and 3A5 have significant substrate overlap, and there is currently no way to selectively monitor the activity of these two enzymes, which has led to the er
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865b6400f1fdd45a1cdaa36e006acbf5
https://pubmed.ncbi.nlm.nih.gov/24335391
https://pubmed.ncbi.nlm.nih.gov/24335391
We report a concise and convergent laboratory synthesis of the rare marine natural product lehualide B that has led to the discovery that (1) this compound has low nanomolar activity against human multiple myeloma cells and (2) the anticancer effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f85d061094f83454e66d3f62a8a6e83
https://europepmc.org/articles/PMC3758376/
https://europepmc.org/articles/PMC3758376/
Autor:
Todd Macklin, Philip LoGrasso, Valer Jeso, Glenn C. Micalizio, Subhas Chandra Pan, Lisa Cherry
Publikováno v:
Organic letters. 13(19)
A convergent synthesis of benzoquinone ansamycin analogs is described that proceeds by a sequence of metallacycle-mediated alkyne–alkyne coupling, followed by site- and stereoselective dihydroxylation and global carbamate formation. These studies h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80bea0ed50c94e769b1cf55f4a4fb615
https://pubmed.ncbi.nlm.nih.gov/21866939
https://pubmed.ncbi.nlm.nih.gov/21866939
Autor:
Glenn C. Micalizio, Valer Jeso
The total synthesis of anticancer marine natural product lehualide B is described. Overall, the synthesis proceeds in just eight steps from a simple gamma-pyrone, does not require the use of protecting groups, and delivers each nonconjugated trisubst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b68aa9e20ac0864f015cd439bf54aa8
https://europepmc.org/articles/PMC2923668/
https://europepmc.org/articles/PMC2923668/