Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Valentino M, Gantz"'
Autor:
Tim Harvey-Samuel, Xuechun Feng, Emily M. Okamoto, Deepak-Kumar Purusothaman, Philip T. Leftwich, Luke Alphey, Valentino M. Gantz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Culex mosquitoes pose a significant public health threat as vectors for a variety of diseases including West Nile virus and lymphatic filariasis, and transmit pathogens threatening livestock, companion animals, and endangered birds. Rampant
Externí odkaz:
https://doaj.org/article/6c6b8a29badb4542adef758e894e7667
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Programmable double-strand DNA breaks (DSBs) can be harnessed for precision genome editing through manipulation of the homology-directed repair (HDR) pathway. Here the authors report the development of the double tap - double tap implements secondary
Externí odkaz:
https://doaj.org/article/254830d1927141acbd0de90b8e5767f7
Autor:
Alena L. Bishop, Víctor López Del Amo, Emily M. Okamoto, Zsolt Bodai, Alexis C. Komor, Valentino M. Gantz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
CRISPR gene drives are genetic elements capable of quickly spreading through populations and they offer promising solutions for curbing the spread of vector-borne diseases and controlling crop pest and invasive species populations. Here the authors p
Externí odkaz:
https://doaj.org/article/bad9dc227a0746a1a7492c5a98f8ac9d
Autor:
Zhiqian Li, Nimi Marcel, Sushil Devkota, Ankush Auradkar, Stephen M. Hedrick, Valentino M. Gantz, Ethan Bier
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
CRISPR-based genetic elements can copy themselves across host genomes. Here the authors introduce CopyCatcher, a gene-drive related system for detecting and quantifying somatic gene conversion events.
Externí odkaz:
https://doaj.org/article/b94ecd06f7bb42bcb6d8bcbcc6d0a9f1
Autor:
Xuechun Feng, Víctor López Del Amo, Enzo Mameli, Megan Lee, Alena L. Bishop, Norbert Perrimon, Valentino M. Gantz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Culex mosquitoes are a global vector for insect-borne diseases, though progress with genetic tools lags behind other mosquito species. Here the authors present a Cas9-based toolkit and methods that could support future gene drive development in these
Externí odkaz:
https://doaj.org/article/819b1068923347549588f7ff68d80acf
Autor:
Adriana Adolfi, Valentino M. Gantz, Nijole Jasinskiene, Hsu-Feng Lee, Kristy Hwang, Gerard Terradas, Emily A. Bulger, Arunachalam Ramaiah, Jared B. Bennett, J. J. Emerson, John M. Marshall, Ethan Bier, Anthony A. James
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Gene drives may be impeded by the generation of resistant alleles following NHEJ. Here the authors develop a recoded gene-drive rescue system for the malaria mosquito, Anopheles stephensi, that targets the drive to the kynurenine hydroxylase gene for
Externí odkaz:
https://doaj.org/article/518d7f7cbf0f452ca061cd7fb7e5d83b
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 2, Pp 827-837 (2020)
Externí odkaz:
https://doaj.org/article/dd0732a8ff6f4de9ae0eeb1d48d19096
Autor:
Víctor López Del Amo, Alena L. Bishop, Héctor M. Sánchez C., Jared B. Bennett, Xuechun Feng, John M. Marshall, Ethan Bier, Valentino M. Gantz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Gene drives raise safety concerns around unintended propagation. Here the authors present a trans-complementing split-gene drive that requires inheritance of separate transgenes to assemble a fully functional drive.
Externí odkaz:
https://doaj.org/article/656384f4cb644824ac325eaeb9b29a92
Autor:
Alexander J Weitzel, Hannah A Grunwald, Ceri Weber, Rimma Levina, Valentino M Gantz, Stephen M Hedrick, Ethan Bier, Kimberly L Cooper
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001478 (2021)
Highly efficient gene conversion systems have the potential to facilitate the study of complex genetic traits using laboratory mice and, if implemented as a "gene drive," to limit loss of biodiversity and disease transmission caused by wild rodent po
Externí odkaz:
https://doaj.org/article/baaab7397acd4441888d4b328da69680
Autor:
Annabel Guichard, Tisha Haque, Marketta Bobik, Xiang-Ru S. Xu, Carissa Klanseck, Raja Babu Singh Kushwah, Mateus Berni, Bhagyashree Kaduskar, Valentino M. Gantz, Ethan Bier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Gene-drives use CRISPR-Cas9 to be transmitted in a super-Mendelian fashion. Here the authors develop an allelic-drive for selective inheritance of a desired allele.
Externí odkaz:
https://doaj.org/article/d84a958ee4384c8680de46671dd3e198