Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Valentino J. Stella"'
Publikováno v:
AAPS Open, Vol 3, Iss 1, Pp 1-14 (2017)
Abstract The non-isothermal method for prediction of chemical stability of pharmaceuticals has been discussed in the literature for almost half a century but it has not yet been systematically evaluated. The purpose of this study was to carry out a c
Externí odkaz:
https://doaj.org/article/d207617693374074a66cd8f66e0c0ad3
Publikováno v:
Journal of Pharmaceutical Sciences. 110:543-547
The solubility of bortezomib, a boronic acid, in water and normal saline is often misquoted in the literature. Here we confirm that bortezomib equilibrium solubility in water and normal saline is 0.59 ± 0.07 and 0.52 ± 0.11 mg/mL, respectively. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b23ba839d0edb4233c0e1ce03892f50
https://doi.org/10.1016/j.xphs.2020.10.012
https://doi.org/10.1016/j.xphs.2020.10.012
Autor:
Valentino J. Stella
Publikováno v:
Journal of Pharmaceutical Sciences. 109:3514-3523
This review presents my early exploration in the area of prodrugs and specifically prodrugs of the anticonvulsant, phenytoin, also called diphenylhydantoin. My journey started in graduate school with an introduction to the prodrug concept and continu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b36bb7c80dfb04ada8fe9adc56131e
https://doi.org/10.1016/j.xphs.2020.09.037
https://doi.org/10.1016/j.xphs.2020.09.037
Publikováno v:
Journal of Pharmaceutical Sciences. 108:3281-3288
The purpose of this study is to assess some of the variables determining the aldol-like condensation of pyruvic acid (1), a peroxide scavenger, in aqueous solution to parapyruvic acid and higher oligomers. Its stability is compared to 3 other α-keto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ba98f3632f001fb4f2ea8fd9e1f106
https://doi.org/10.1016/j.xphs.2019.05.030
https://doi.org/10.1016/j.xphs.2019.05.030
Publikováno v:
Journal of pharmaceutical sciences. 109(8)
This review provides insight into the use of boric acid as a pharmaceutical, a buffer, and an adjuvant/excipient in pharmaceutical formulations. Boric acid is a Lewis acid with a pKa of 8.92–9.24 that is sensitive to temperature, ionic strength, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5910e13ccffbe991d780129b7f6f0600
https://pubmed.ncbi.nlm.nih.gov/32353453
https://pubmed.ncbi.nlm.nih.gov/32353453
Publikováno v:
European Journal of Pharmaceutical Sciences. 124:10-16
The purpose of this study is to try to identify the etiology and formulation implications of the significant pKa drop in aqueous solution that occurs when boronic acids are reversibly esterified by reaction with alcohols, especially 1,2-diols. Experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e43de80e8288eda4eaa8910573efcf09
https://doi.org/10.1016/j.ejps.2018.08.017
https://doi.org/10.1016/j.ejps.2018.08.017
Publikováno v:
Drug and Alcohol Dependence. 186:159-166
Objectives Prescription stimulants are vulnerable to oral and parenteral abuse. Intravenous forms of abuse may be most detrimental due to an enhanced risk of dependence, overdose, and infectious diseases. Our objective was to discover an orally activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae67483b872321cb7e7d7d176ab9b2d
https://doi.org/10.1016/j.drugalcdep.2017.12.042
https://doi.org/10.1016/j.drugalcdep.2017.12.042
Publikováno v:
AAPS Open, Vol 3, Iss 1, Pp 1-14 (2017)
The non-isothermal method for prediction of chemical stability of pharmaceuticals has been discussed in the literature for almost half a century but it has not yet been systematically evaluated. The purpose of this study was to carry out a comprehens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8e7b78eeb7475922c85b3d8578ea21
http://link.springer.com/article/10.1186/s41120-017-0012-y
http://link.springer.com/article/10.1186/s41120-017-0012-y
Autor:
Kirsten M. Phizackerley, Christopher D. Ablan, Mouhannad Jumaa, Valentino J. Stella, Antonio Lopalco, Bradley H. Wolfe
Publikováno v:
Journal of Pharmaceutical Sciences. 106:1051-1061
The anticancer agent, carfilzomib, has a unique α-keto-epoxide warhead. The model α-keto-epoxide, N-((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)pivalamide (1), along with a few of its degradation products was synthesized and studied.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbffd09eb5354d8b5bab3ea04d1db5a
https://doi.org/10.1016/j.xphs.2016.12.006
https://doi.org/10.1016/j.xphs.2016.12.006
Publikováno v:
Journal of Pharmaceutical Sciences. 106:601-610
The purpose of this study was to determine the aqueous solubility of a model phenyl boronic acid, 4-methoxybenzeneboronic acid, as a function of pH both in the absence and in the presence of varying D-mannitol concentration. Solid isolated D-mannitol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97bc32ed3c78085d70d0be93fadf31c
https://doi.org/10.1016/j.xphs.2016.10.022
https://doi.org/10.1016/j.xphs.2016.10.022