Extracellular Loops Are Essential for the Assembly and Function of Polycystin Receptor-Ion Channel Complexes

Autor: Salehi-Najafabadi, Zahra, Li, Bin, Valentino, Victoria, Ng, Courtney, Martin, Hannah, Yu, Yang, Wang, Zhifei, Kashyap, Parul, Yu, Yong

Publikováno v: In Journal of Biological Chemistry 10 March 2017 292(10):4210-4221

A Gain-of-Function TRPP2 Ion Channel Created by Mutating Single Amino Acid in the S5 Transmembrane Domain

Autor: Arif Pavel, Mahmud, Lv, Caixia, Ng, Courtney, Kashyap, Parul, Lam, Clarissa, Valentino, Victoria, Fung, Helen, Campbell, Thomas, Zenisek, David, Holtzman, Nathalia G., Yu, Yong

Publikováno v: In Biophysical Journal 3 February 2017 112(3) Supplement 1:249a-250a

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Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant.

Autor: Arif Pavel M; Department of Biological Sciences, St. John's University, Queens, NY 11439;, Lv C; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520;, Ng C; Department of Biological Sciences, St. John's University, Queens, NY 11439;, Yang L; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10065;, Kashyap P; Department of Biological Sciences, St. John's University, Queens, NY 11439;, Lam C; Department of Biological Sciences, St. John's University, Queens, NY 11439;, Valentino V; Department of Biological Sciences, St. John's University, Queens, NY 11439;, Fung HY; Department of Biological Sciences, St. John's University, Queens, NY 11439;, Campbell T; Department of Biological Sciences, St. John's University, Queens, NY 11439;, Møller SG; Department of Biological Sciences, St. John's University, Queens, NY 11439;, Zenisek D; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520;, Holtzman NG; Department of Biology, Queens College, City University of New York, Queens, NY 11367; The Graduate Center, City University of New York, New York, NY 10016., Yu Y; Department of Biological Sciences, St. John's University, Queens, NY 11439; yuy2@stjohns.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Apr 26; Vol. 113 (17), pp. E2363-72. Date of Electronic Publication: 2016 Apr 11.