Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Valentine Sergeev"'
Autor:
Pearce G. Wilcox, Frank Y Chou, Valentine Sergeev, Bradley S. Quon, Grace Y. Lam, Christopher Michael Hamilton
Publikováno v:
Annals of the American Thoracic Society
The effects of cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulators on lung function, pulmonary exacerbations, and quality of life have been well documented. However, CF is a multiorgan disease, and therefore an evidence base is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e83bdfd0aadfea6541e3216aa7c389
https://doi.org/10.1513/annalsats.201909-671cme
https://doi.org/10.1513/annalsats.201909-671cme
Autor:
Victoria Su, Jane Kerr, Valentine Sergeev, Sameer Desai, Pearce G. Wilcox, Bradley S. Quon, Eri Flores
Publikováno v:
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 4:174-179
Lumacaftor-ivacaftor (LUM-IVA) was approved for use in Canada in January 2016. Observational studies have reported a higher incidence of treatment-emergent adverse events (AEs) leading to treatment...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a5e36ebab7f5f62898dde08e44fc736
https://doi.org/10.1080/24745332.2019.1649608
https://doi.org/10.1080/24745332.2019.1649608
Autor:
ZhaoKai Pang, Ravichandra Venkateshappa, Dominic G. Whittaker, Gary R. Mirams, Valentine Sergeev, Glen F. Tibbits, Thomas W. Claydon, Jacob M Kemp, Raj Johal
Publikováno v:
The Journal of General Physiology
Kemp et al. show that the hERG channel activator RPR260243 restores the repolarizing current of a mutant variant of the channel associated with LQTS2 with little effect on its resurgent current. This drug represents a therapeutic opportunity for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f19ef19ae0d8d9059439829ec3c870
https://pubmed.ncbi.nlm.nih.gov/34398210
https://pubmed.ncbi.nlm.nih.gov/34398210
Autor:
James Young, Samrat Thouta, Yen May Cheng, Valentine Sergeev, Yu Patrick Shi, Thomas W. Claydon, Christina M. Hull
Publikováno v:
Biophysical Journal. 112:300-312
Slow deactivation of hERG channels is critical for preventing cardiac arrhythmia yet the mechanistic basis for the slow gating transition is unclear. Here, we characterized the temporal sequence of events leading to voltage sensor stabilization upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf769abe3f5eebb2477bc7a44ed6ad5b
https://doi.org/10.1016/j.bpj.2016.12.021
https://doi.org/10.1016/j.bpj.2016.12.021
Autor:
Shubhayan Sanatani, Thomas M. Roston, Frances Perry, Glen F. Tibbits, Valentine Sergeev, Thomas W. Claydon
Publikováno v:
Forensic science international. 284
Long QT syndrome (LQTS) is the most common cardiac ion channelopathy and has been found to be responsible for approximately 10% of sudden infant death syndrome (SIDS) cases. Despite increasing use of broad panels and now whole exome sequencing (WES)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ea5bf7284ddebdd1dd7ebd691f189e
https://pubmed.ncbi.nlm.nih.gov/29331839
https://pubmed.ncbi.nlm.nih.gov/29331839