Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Valentine R, St Hilaire"'
Autor:
Valentine R. St. Hilaire, William E. Hopkins, Yenteeo S. Miller, Srinivasa R. Dandepally, Alfred L. Williams
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 72-78 (2019)
The regioselective addition of Grignard reagents to mono- and disubstituted N-acylpyrazinium salts affording substituted 1,2-dihydropyrazines in modest to excellent yields (45–100%) is described. Under acidic conditions, these 1,2-dihydropyrazines
Externí odkaz:
https://doaj.org/article/e47bc779dd024d47b625b58bbd5df528
Autor:
Alfred L. Williams, William E Hopkins, Yenteeo S Miller, Valentine R. St. Hilaire, Srinivasa R. Dandepally
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 72-78 (2019)
The regioselective addition of Grignard reagents to mono- and disubstituted N-acylpyrazinium salts affording substituted 1,2-dihydropyrazines in modest to excellent yields (45–100%) is described. Under acidic conditions, these 1,2-dihydropyrazines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6850e82e12ddfa02e22fdc50d138133
https://doi.org/10.3762/bjoc.15.8
https://doi.org/10.3762/bjoc.15.8
Autor:
Syed Ahmad, Valentine R. St. Hilaire, Gary L. Johnson, Srinivasa R. Dandepally, Alfred L. Williams, John E. Scott
Publikováno v:
Biochemical and Biophysical Research Communications. 496:205-211
The kinase MEKK2 (MAP3K2) activates the MEK5/ERK5 cell signaling pathway and may play an important role in tumor growth and metastasis. Thus, MEKK2 may represent a novel kinase target for cancer. In order to identify inhibitors of MEKK2, we screened
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2c5f2b0736238f8568e07025a255e1
https://doi.org/10.1016/j.bbrc.2018.01.027
https://doi.org/10.1016/j.bbrc.2018.01.027
Publikováno v:
Tetrahedron. 73:6712-6717
Starting from 3-methoxy N -acylpyrazinium salts, a new approach towards the synthesis of the antischistosomal drug praziquantel (PZQ) has been developed. Utilization of a palladium-catalyzed intramolecular Heck reaction to form dehydro-PZQ followed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::182ca95082c51c54aac896d3e6be1c0d
https://doi.org/10.1016/j.tet.2017.10.006
https://doi.org/10.1016/j.tet.2017.10.006
Autor:
Valentine R, St Hilaire, William E, Hopkins, Yenteeo S, Miller, Srinivasa R, Dandepally, Alfred L, Williams
Publikováno v:
Beilstein Journal of Organic Chemistry
The regioselective addition of Grignard reagents to mono- and disubstituted N-acylpyrazinium salts affording substituted 1,2-dihydropyrazines in modest to excellent yields (45–100%) is described. Under acidic conditions, these 1,2-dihydropyrazines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21bf4e0e02f82fd1aa50e2152a255c4e
https://pubmed.ncbi.nlm.nih.gov/30680041
https://pubmed.ncbi.nlm.nih.gov/30680041
Publikováno v:
The Journal of Organic Chemistry. 77:4097-4102
The regioselective reduction of 3-substituted N-acylpyrazinium salts with n-Bu(3)SnH has been developed for the synthesis of 3-substituted 1,2-dihydropyrazines in yields of 56-94%. Substitution of the pyrazinium salts with electron-donating groups fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a6075813f12d8de21e860d99884070
https://doi.org/10.1021/jo202498r
https://doi.org/10.1021/jo202498r
Publikováno v:
ChemInform. 43
In the presence of Bu3SnH, N-acylpyrazinium salts bearing an electron-donating group in position 3 undergo regioselective reduction yielding 1,2-dihydropyrazines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c48feb003ccbefa613104522967942e
https://doi.org/10.1002/chin.201233183
https://doi.org/10.1002/chin.201233183
Publikováno v:
Organic Letters. 1:1957-1959
The protonation of heterocyclic diazotates (attachment adjacent to a nitrogen atom) yields ring-centered heterocyclic carbocations that are highly reactive. The carbocations were found to alkylate aromatic and heterocyclic compounds, such as benzene,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::add837e9403a79b6d462611dc409fa46
https://doi.org/10.1021/ol990310q
https://doi.org/10.1021/ol990310q