Potent Antiplasmodial Derivatives of Dextromethorphan Reveal the Ent-Morphinan Pharmacophore of Tazopsine-Type Alkaloids

Autor: Antoinette Keita, Jean-François Franetich, Maëlle Carraz, Loïse Valentin, Mallaury Bordessoules, Ludivine Baron, Pierre Bigeard, Florian Dupuy, Valentine Geay, Maurel Tefit, Véronique Sarrasin, Sylvie Michel, Catherine Lavazec, Sandrine Houzé, Dominique Mazier, Valérie Soulard, François-Hugues Porée, Romain Duval

Publikováno v: Pharmaceutics, Vol 14, Iss 2, p 372 (2022)

The alkaloid tazopsine 1 was introduced in the late 2000s as a novel antiplasmodial hit compound active against Plasmodium falciparum hepatic stages, with the potential to develop prophylactic drugs based on this novel chemical scaffold. However, the

Externí odkaz: https://doaj.org/article/3fc9ea2820e74cef814d989498dd85d9

Potent Antiplasmodial Derivatives of the Antitussive Drug Dextromethorphan Reveal the Ent-Morphinan Pharmacophore of Tazopsine-Type Alkaloids

Autor: Antoinette Keita, Jean-François Franetich, Maelle Carraz, Loise Valentin, Mallaury Bordesoulles, Ludivine Baron, Pierre Bigeard, Florian Dupuy, Valentine Geay, Maurel Tefit, Véronique Sarrasin, Sylvie Michel, Catherine Lavazec, Sandrine Houzé, Dominique Mazier, Valérie Soulard, François-Hugues Porée, Romain Duval

The alkaloid tazopsine 1 was introduced in the late 2000's as a novel antiplasmodial hit compound active against Plasmodium falciparum hepatic stages, with potential to develop prophylactic drugs based on this novel chemical scaffold. However, the st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f98d27ba889015e71967704856959fb
https://doi.org/10.20944/preprints202201.0063.v1

Potent Antiplasmodial Derivatives of Dextromethorphan Reveal the Ent -Morphinan Pharmacophore of Tazopsine-Type Alkaloids.

Autor: Keita, Antoinette¹ (AUTHOR) antoinettekeita22@yahoo.com, Franetich, Jean-François² (AUTHOR) jean-francois.franetich@upmc.fr, Carraz, Maëlle³ (AUTHOR) maelle.carraz@ird.fr, Valentin, Loïse^2,4 (AUTHOR) loise.valentin@gmail.com, Bordessoules, Mallaury² (AUTHOR) mallaurybordessoulles@gmail.com, Baron, Ludivine² (AUTHOR) ludivine.baron.bio@gmail.com, Bigeard, Pierre² (AUTHOR) pierre.bigeard71@gmail.com, Dupuy, Florian^5,6 (AUTHOR) florian.dupuy@inserm.fr, Geay, Valentine⁷ (AUTHOR) valentine.geay@gmail.com, Tefit, Maurel² (AUTHOR) maurel.tefit@upmc.fr, Sarrasin, Véronique⁸ (AUTHOR) veronique.sarrasin-hubert@aphp.fr, Michel, Sylvie⁷ (AUTHOR) sylvie.michel@u-paris.fr, Lavazec, Catherine^5,6 (AUTHOR) catherine.lavazec@inserm.fr, Houzé, Sandrine^1,8 (AUTHOR) sandrine.houze@aphp.fr, Mazier, Dominique² (AUTHOR) dominique.mazier@sorbonne-universite.fr, Soulard, Valérie² (AUTHOR) valerie.soulard@upmc.fr, Porée, François-Hugues⁹ (AUTHOR) francois-hugues.poree@univ-rennes1.fr, Duval, Romain¹ (AUTHOR) francois-hugues.poree@univ-rennes1.fr

Publikováno v: Pharmaceutics. Feb2022, Vol. 14 Issue 2, p372. 1p.