Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Valentina Zuco"'
Autor:
Valentina Zuco, Sandro Pasquali, Monica Tortoreto, Stefano Percio, Valentina Doldi, Marta Barisella, Paola Collini, Gian Paolo Dagrada, Silvia Brich, Patrizia Gasparini, Marco Fiore, Michela Casanova, Anna Maria Frezza, Alessandro Gronchi, Silvia Stacchiotti, Andrea Ferrari, Nadia Zaffaroni
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/3d75078d3e72425ba09846afe0757812
Autor:
Valentina Zuco, Sandro Pasquali, Monica Tortoreto, Silvia Brich, Stefano Percio, Gian Paolo Dagrada, Chiara Colombo, Roberta Sanfilippo, Calogero Lauricella, Mrinal Gounder, Rihan El Bezawy, Marta Barisella, Angelo Paolo Dei Tos, Paolo Giovanni Casali, Alessandro Gronchi, Silvia Stacchiotti, Nadia Zaffaroni
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-12 (2021)
Abstract Background Dedifferentiated liposarcoma (DDLPS), a tumor that lacks effective treatment strategies and is associated with poor outcomes, expresses amplified MDM2 in the presence of wild-type p53. MDM2 ubiquitination of p53 facilitates its XP
Externí odkaz:
https://doaj.org/article/7da031e33ebf48729291cb024f6f6183
Autor:
Rihan El Bezawy, Stella Tinelli, Monica Tortoreto, Valentina Doldi, Valentina Zuco, Marco Folini, Claudio Stucchi, Tiziana Rancati, Riccardo Valdagni, Paolo Gandellini, Nadia Zaffaroni
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-11 (2019)
Abstract Background Radiotherapy is one of the main treatment options for non-metastatic prostate cancer (PCa). Although treatment technical optimization has greatly improved local tumor control, a considerable fraction of patients still experience r
Externí odkaz:
https://doaj.org/article/027135c8d7f44307a37a1e7c2afbf0e1
Autor:
Irene Alessandrini, Stefano Percio, Eisa Naghshineh, Valentina Zuco, Silvia Stacchiotti, Alessandro Gronchi, Sandro Pasquali, Nadia Zaffaroni, Marco Folini
Publikováno v:
Cancers, Vol 14, Iss 11, p 2624 (2022)
Background: Well-differentiated (WD)/dedifferentiated (DD) liposarcoma (LPS) accounts for ~60% of retroperitoneal sarcomas. WDLPS and DDLPS divergently evolve from a common precursor and are both marked by the amplification of the 12q13–q15 region,
Externí odkaz:
https://doaj.org/article/f8213f3cf9ae46de940b1b85807bbeb6
Autor:
Silvia Martini, Valentina Zuco, Monica Tortoreto, Stefano Percio, Elisa Campi, Rihan El Bezawy, Valentina Doldi, Yosef Landesman, Marzia Pennati, Nadia Zaffaroni
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 523 (2021)
Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Here, we pursued a combinatorial therapeutic approach to enhance the activity of selinexor, the first-in-class XPO1 inhibitor, by miR-34a ectopic expressi
Externí odkaz:
https://doaj.org/article/b5d9b2022b374d4caa774c33c5ffe47c
Autor:
Rihan El Bezawy, Michelandrea De Cesare, Marzia Pennati, Marcello Deraco, Paolo Gandellini, Valentina Zuco, Nadia Zaffaroni
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-14 (2017)
Abstract Background The value of microRNAs (miRNAs) as novel targets for cancer therapy is now widely recognized. However, no information is currently available on the expression/functional role of miRNAs in diffuse malignant peritoneal mesothelioma
Externí odkaz:
https://doaj.org/article/5fcd33ccb4024852870b744b30bd3645
Autor:
Rihan El Bezawy, Martina Tripari, Stefano Percio, Alessandro Cicchetti, Monica Tortoreto, Claudio Stucchi, Stella Tinelli, Valentina Zuco, Valentina Doldi, Paolo Gandellini, Riccardo Valdagni, Nadia Zaffaroni
Publikováno v:
Cancers, Vol 12, Iss 6, p 1462 (2020)
Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is the most commonly mutated gene in prostate cancer (PCa). Recent evidence reports a role of SPOP in DNA damage response (DDR), indicating a possible impact of SPOP deregulation on
Externí odkaz:
https://doaj.org/article/592c63ba3e9f40e3a8b1d176f1c5cd48
Autor:
Federica Rotundo, Denis Cominetti, Rihan El Bezawy, Stefano Percio, Valentina Doldi, Monica Tortoreto, Valentina Zuco, Riccardo Valdagni, Nadia Zaffaroni, Paolo Gandellini
Publikováno v:
Cells, Vol 9, Iss 2, p 435 (2020)
The development of novel therapies or the improvement of currently used approaches to treat prostate cancer (PCa), the most frequently diagnosed male tumor in developed countries, is an urgent need. In this regard, the functional characterization of
Externí odkaz:
https://doaj.org/article/590c713293aa45f4aa3a6a7bd25e6785
Autor:
Silvia Stacchiotti, Valentina Zuco, Monica Tortoreto, Denis Cominetti, Anna Maria Frezza, Stefano Percio, Valentina Indio, Marta Barisella, Valentina Monti, Silvia Brich, Annalisa Astolfi, Chiara Colombo, Sandro Pasquali, Marco Folini, Mrinal M. Gounder, Maria A. Pantaleo, Paola Collini, Angelo Paolo Dei Tos, Paolo Giovanni Casali, Alessandro Gronchi, Nadia Zaffaroni
Publikováno v:
Cancers, Vol 11, Iss 7, p 1015 (2019)
Epithelioid sarcoma (ES) is a rare mesenchymal malignancy marked by SMARCB1/INI1 deficiency. Retrospective clinical data report on the activity of anthracycline- and gemcitabine-based regimens. EZH2 inhibitors are currently being tested in clinical t
Externí odkaz:
https://doaj.org/article/0ba564cef2aa405087f6283f9b9b49ef
Autor:
Valentina Zuco, Franco Zunino
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 6, Pp 587-596 (2008)
As a consequence of multiple functions of p53, its activation in response to cytotoxic stress may have proapoptotic or protective effects depending on the nature of lesions. We have previously shown that mutational inactivation of p53 results in sens
Externí odkaz:
https://doaj.org/article/d77e3bdd005e4dadb615a6927f29c97c