Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Valentina Uivaroși"'
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 804 (2023)
Antibacterial fluoroquinolones (FQs) are frequently used in treating infections. However, the value of FQs is debatable due to their association with severe adverse effects (AEs). The Food and Drug Administration (FDA) issued safety warnings concerni
Externí odkaz:
https://doaj.org/article/79fa436959ad4187a4fb554719f90e93
Autor:
Ana-Madalina Maciuca, Alexandra-Cristina Munteanu, Mirela Mihaila, Mihaela Badea, Rodica Olar, George Mihai Nitulescu, Cristian V. A. Munteanu, Valentina Uivarosi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 1010 (2022)
“Drug repositioning” is a modern strategy used to uncover new applications for out-of-date drugs. In this context, nalidixic acid, the first member of the quinolone class with limited use today, has been selected to obtain nine new metal complexe
Externí odkaz:
https://doaj.org/article/2690ca2fe5dc477f90f6fe6cee8c5042
Autor:
Mirela Mihaila, Camelia Mia Hotnog, Marinela Bostan, Alexandra Cristina Munteanu, Ileana Adela Vacaroiu, Lorelei Irina Brasoveanu, Valentina Uivarosi
Publikováno v:
Applied Sciences, Vol 11, Iss 18, p 8594 (2021)
Cisplatin is one of the most effective anticancer agents used to treat colon cancer, which is the third malignancy between the most common human cancers in the world, but the resistance developed represents an obstacle against the full success of che
Externí odkaz:
https://doaj.org/article/4c477b872dac4c9ba5140ad8e7e438d0
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 874 (2021)
The widespread use of antibiotics has resulted in the emergence of drug-resistant populations of microorganisms. Clearly, one can see the need to develop new, more effective, antimicrobial agents that go beyond the explored ‘chemical space’. In t
Externí odkaz:
https://doaj.org/article/af05a6591e39422a88f833deba4f2b3a
Publikováno v:
Molecules, Vol 25, Iss 24, p 5830 (2020)
Every year, more Cu(II) complexes are proven to be biologically active species, but very few are developed as drugs or entered in clinical trials. This is due to their poor water solubility and lipophilicity, low stability as well as in vivo inactiva
Externí odkaz:
https://doaj.org/article/adac74cf68364bbf99f405c64d3f3c47
Autor:
Ana-Madalina Maciuca, Alexandra-Cristina Munteanu, Mirela Mihaila, Mihaela Badea, Rodica Olar, George Mihai Nitulescu, Cristian V. A. Munteanu, Marinela Bostan, Valentina Uivarosi
Publikováno v:
Molecules, Vol 25, Iss 22, p 5418 (2020)
“Drug repositioning” is a current trend which proved useful in the search for new applications for existing, failed, no longer in use or abandoned drugs, particularly when addressing issues such as bacterial or cancer cells resistance to current
Externí odkaz:
https://doaj.org/article/a647633fe24b4cd78e872f4995e239e7
Publikováno v:
Molecules, Vol 25, Iss 6, p 1347 (2020)
Quinolones comprise a series of synthetic bactericidal agents with a broad spectrum of activity and good bioavailability. An important feature of these molecules is their capacity to bind metal ions in complexes with relevant biological and analytica
Externí odkaz:
https://doaj.org/article/e9a8a9530f8248a993cac1939ed0ce73
Autor:
Stefania-Felicia Barbuceanu, Diana Carolina Ilies, Gabriel Saramet, Valentina Uivarosi, Constantin Draghici, Valeria Radulescu
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 6, Pp 10908-10925 (2014)
In the present investigation, new hydrazinecarbothioamides 4–6 were synthesized by reaction of 4-(4-X-phenylsulfonyl)benzoic acids hydrazides (X= H, Cl, Br) 1–3 with 2,4-difluorophenyl isothiocyanate and further these were treated with sodium hyd
Externí odkaz:
https://doaj.org/article/12acbc0276364b5c8caaa8d4cf69674d
Autor:
Ana-Mădălina Măciucă, Mihaela Badea, Rodica Olar, Alexandra Cristina Munteanu, Valentina Uivarosi
Publikováno v:
Proceedings, Vol 29, Iss 1, p 65 (2019)
The growing interest in metal-quinolone complexes is sustained by a large number of compounds obtained and tested for antibacterial [1], antitumoral [1,2], antifungal [1], and antiparasitic [3] properties. [...]
Externí odkaz:
https://doaj.org/article/a42960c3ea7c44ab9e90bd6a9e66ef23
Autor:
Valeria-Nicoleta Vătavu, Mihaela Badea, Rodica Olar, Ariana Hudiță, Bianca Gălățeanu, Alexandra Cristina Munteanu, Valentina Uivarosi
Publikováno v:
Proceedings, Vol 29, Iss 1, p 118 (2019)
Diabetes mellitus (DM) is a disease characterized by chronic hyperglycemia caused by absolute [...]
Externí odkaz:
https://doaj.org/article/aedeb2e6b59c45b0a9b3be2c477987b2