Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Valentina Tassinari"'
Autor:
Lorenzo Cuollo, Samuele Di Cristofano, Annamaria Sandomenico, Emanuela Iaccarino, Angela Oliver, Alessandra Zingoni, Marco Cippitelli, Cinzia Fionda, Sara Petillo, Andrea Kosta, Valentina Tassinari, Maria Teresa Petrucci, Francesca Fazio, Menotti Ruvo, Angela Santoni, Domenico Raimondo, Alessandra Soriani
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109814- (2024)
Summary: 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) is the endogenous agonist of STING; as such, cGAMP has powerful immunostimulatory activity, due to its capacity to stimulate type I interferon-mediated immunity. Recen
Externí odkaz:
https://doaj.org/article/d8e6f044263540b99c87c79122f65561
Autor:
Valentina Tassinari, Antonella Smeriglio, Virgilio Stillittano, Domenico Trombetta, Romano Zilli, Roberta Tassinari, Francesca Maranghi, Giulia Frank, Daniele Marcoccia, Laura Di Renzo
Publikováno v:
Nutrients, Vol 15, Iss 13, p 2967 (2023)
Endometriosis is an estrogen-dependent common chronic inflammatory disease defined by the presence of extrauterine endometrial tissue that promotes pelvic pain and fertility impairment. Its etiology is complex and multifactorial, and several not comp
Externí odkaz:
https://doaj.org/article/9dd56b1027194511b5aacaf856127d19
Autor:
Valentina Tassinari, Valeriana Cesarini, Sara Tomaselli, Zaira Ianniello, Domenico Alessandro Silvestris, Lavinia Ceci Ginistrelli, Maurizio Martini, Biagio De Angelis, Gabriele De Luca, Lucia Ricci Vitiani, Alessandro Fatica, Franco Locatelli, Angela Gallo
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)
Abstract Background N 6 -methyladenosine (m6A) and adenosine-to-inosine (A-to-I) RNA editing are two of the most abundant RNA modification events affecting adenosines in mammals. Both these RNA modifications determine mRNA fate and play a pivotal rol
Externí odkaz:
https://doaj.org/article/5d85b707035d4060a6ccea59877b0a3b
Autor:
Valeriana Cesarini, Domenico Alessandro Silvestris, Federica Galeano, Valentina Tassinari, Maurizio Martini, Franco Locatelli, Angela Gallo
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1142 (2022)
Background: Epitranscriptomic mechanisms, such as A-to-I RNA editing mediated by ADAR deaminases, contribute to cancer heterogeneity and patients’ stratification. ADAR enzymes can change the sequence, structure, and expression of several RNAs, affe
Externí odkaz:
https://doaj.org/article/2f0b92a1604f4260aa52a4e16ef66b76
Publikováno v:
Biology, Vol 11, Iss 4, p 568 (2022)
A-to-I editing is a post-transcriptional mechanism affecting coding and non-coding dsRNAs, catalyzed by the adenosine deaminases acting on the RNA (ADAR) family of enzymes. A-to-I modifications of endogenous dsRNA (mainly derived from Alu repetitive
Externí odkaz:
https://doaj.org/article/2c4424a7b8a14ef1bf79e8ccdaa417e6
Autor:
Simone De Meo, Valentina Dell'Oste, Rosa Molfetta, Valentina Tassinari, Lavinia Vittoria Lotti, Simone Vespa, Benedetta Pignoloni, Daniela Angela Covino, Laura Fantuzzi, Roberta Bona, Alessandra Zingoni, Ilaria Nardone, Matteo Biolatti, Alessandra Coscia, Rossella Paolini, Monsef Benkirane, Fredrik Edfors, Tatyana Sandalova, Adnane Achour, John Hiscott, Santo Landolfo, Angela Santoni, Cristina Cerboni
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008855 (2020)
SAMHD1 is a host restriction factor that functions to restrict both retroviruses and DNA viruses, based on its nuclear deoxynucleotide triphosphate (dNTP) hydrolase activity that limits availability of intracellular dNTP pools. In the present study,
Externí odkaz:
https://doaj.org/article/f761f66d2d31441aba50004cfa6438dd
Autor:
Erica Quagliarini, Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Barbara Sartori, Heinz Amenitsch, Valentina Tassinari, Laura Masuelli, Roberto Bei, Lishan Cui, Junbiao Wang, Augusto Amici, Cristina Marchini, Daniela Pozzi, Giulio Caracciolo
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1292 (2021)
In recent years, lipid nanoparticles (LNPs) have gained considerable attention in numerous research fields ranging from gene therapy to cancer immunotherapy and DNA vaccination. While some RNA-encapsulating LNP formulations passed clinical trials, DN
Externí odkaz:
https://doaj.org/article/a4bdbd952b574c60976f3fdea73c3bc7
Autor:
Valentina Tassinari, Piergiorgio La Rosa, Eugenia Guida, Ambra Colopi, Sara Caratelli, Francesca De Paolis, Angela Gallo, Carlo Cenciarelli, Giuseppe Sconocchia, Susanna Dolci, Valeriana Cesarini
Publikováno v:
Mechanisms of Ageing and Development. 212:111807
Autor:
Eugenia Guida, Valentina Tassinari, Ambra Colopi, Federica Todaro, Valeriana Cesarini, Benedetto Jannini, Manuela Pellegrini, Flavia Botti, Gabriele Rossi, Pellegrino Rossi, Emmanuele A. Jannini, Susanna Dolci
Publikováno v:
Journal of Cell Science. 135
Germ cell tumors (GCTs) are rare tumors that can develop in both sexes, peaking in adolescents. To understand the mechanisms that underlie germ cell transformation, we established a GCT mouse model carrying a germ-cell-specific BRafV600E mutation wit
Publikováno v:
Biology. 11(4)
A-to-I editing is a post-transcriptional mechanism affecting coding and non-coding dsRNAs, catalyzed by the adenosine deaminases acting on the RNA (ADAR) family of enzymes. A-to-I modifications of endogenous dsRNA (mainly derived from Alu repetitive